Boo - Hoo - Hoo : You\u27re Gonna Cry When I\u27m Gone

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Hydroxycobalamin reveals the involvement of hydrogen sulfide in the hypoxic responses of rat carotid body chemoreceptor cells

Producción CientíficaCarotid body (CB) chemoreceptor cells sense arterial blood PO2, generating a neurosecretory response proportional to the intensity of hypoxia. Hydrogen sulfide (H2S) is a physiological gaseous messenger that is proposed to act as an oxygen sensor in CBs, although this concept remains controversial. In the present study we have used the H2S scavenger and vitamin B12 analog hydroxycobalamin (Cbl) as a new tool to investigate the involvement of endogenous H2S in CB oxygen sensing. We observed that the slow-release sulfide donor GYY4137 elicited catecholamine release from isolated whole carotid bodies, and that Cbl prevented this response. Cbl also abolished the rise in [Ca2+]i evoked by 50 µM NaHS in enzymatically dispersed CB glomus cells. Moreover, Cbl markedly inhibited the catecholamine release and [Ca2+]i rise caused by hypoxia in isolated CBs and dispersed glomus cells, respectively, whereas it did not alter these responses when they were evoked by high [K+]e. The L-type Ca2+ channel blocker nifedipine slightly inhibited the rise in CB chemoreceptor cells [Ca2+]i elicited by sulfide, whilst causing a somewhat larger attenuation of the hypoxia-induced Ca2+ signal. We conclude that Cbl is a useful and specific tool for studying the function of H2S in cells. Based on its effects on the CB chemoreceptor cells we propose that endogenous H2S is an amplifier of the hypoxic transduction cascade which acts mainly by stimulating non-L-type Ca2+ channels.Ministerio de Economía, Industria y Competitividad - Fondo Europeo de Desarrollo Regional (project BFU2015-70616-R)Junta de Castilla y León (project VA106G18)Centro de Investigación Biomédica en Red de Enfermedades Respiratorias . Instituto de Salud Carlos III (project CIBER CB06/06/0050

Inflammation, nitro‐oxidative stress and altered autonomic outflow in obstructive sleep apnoea: an assault on homeostasis

Producción CientíficaThe carotid body (CB) acts as a chemoreceptor which, when stimulated by arterial hypoxia, hypercapnia or acidosis, releases transmitters which stimulate sensory afferents that signal to the nucleus tractus solitarius (NTS). Acting through the rostral ventrolateral medulla (RVLM), this initiates a chemoreflex, stimulating autonomic efferents that orchestrate compensatory cardiorespiratory responses. Unfortunately, chronic intermittent hypoxia (CIH), which occurs in obstructive sleep apnoea (OSA), subverts the beneficial homeostatic function of this chemoreflex, causing increases in basal and hypoxia-induced transmitter release by the CB and sensitizing the cardiorespiratory centres it acts through. This causes a chronic sympathetic overdrive, contributing to the pathophysiological consequences of OSA such as heart failure, resistant hypertension and insulin resistance. [Texto del artículo]Junta de Castilla y Leon - Consejería de Educación (CCVC848

The loveliest night of the year

https://digitalcommons.library.umaine.edu/mmb-vp-copyright/2709/thumbnail.jp

Boo-Hoo-Hoo

Illustration of woman in dress cryinghttps://scholarsjunction.msstate.edu/cht-sheet-music/6148/thumbnail.jp

cardiovascular system at a glance

Philip I. Aaronson ... [et al.].125 p. : ill. ; 28 cm

When you are in love it\u27s the loveliest night of the year stars [first line of chorus]

Performers: Mario Lanza, Ann BlythPiano, Voice and Chord

When you are in love it\u27s the loveliest night of the year stars [first line of chorus]

Performers: Mario LanzaPiano, Voice and Chord