12 research outputs found
No evidence of a role of the β4 subunit of the nicotinic acetylcholine receptor in alcohol-related behaviors
- Author
- A Larsson
- AV Flora
- BF Grant
- BJ Bowers
- C Gotti
- CM Butt
- Constanza Silva
- E Perez
- EE Meyers
- EH Shen
- G Joslyn
- H Choquet
- Helen M. Kamens
- HM Kamens
- HM Kamens
- HM Kamens
- HM Kamens
- HM Kamens
- HM Kamens
- HM Kamens
- I Ponomarev
- IR Schlaepfer
- J Hällfors
- J Wu
- J-C Wang
- JC Crabbe
- JC Crabbe
- JC Crabbe
- JS Rhodes
- JS Rhodes
- LM Hendrickson
- LM Hendrickson
- M Zoli
- MA Ehringer
- Marissa A. Ehringer
- MN Symons
- N Santos
- N Taslim
- NK Kamdar
- NS Millar
- O Salminen
- P Bhutada
- PS Bhutada
- R Hingson
- R Salas
- Riley McCarthy
- Ryan J. Cox
- S Chatterjee
- S Rahman
- SA Marshall
- TJ Phillips
- TJ Phillips
- TJ Phillips
- W Xu
- X Gallego
- X Gallego
- ZJ Ren
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sleep and Delirium in Older Adults
- Author
- A Foy
- A Morandi
- A Sadeh
- AB Fadayomi
- AC Parrott
- AC Trompeo
- AE Wolters
- AH Flannery
- AH Heck
- AJ Slooter
- AM MacLullich
- AR Green
- AV Benjafield
- B Toublanc
- BB Kamdar
- BB Kamdar
- BB Kamdar
- BB Kamdar
- BB Kamdar
- BB Kamdar
- BB Kamdar
- BJ Flink
- BP Lucey
- BT Pun
- BW Ellis
- CN Sessler
- D Wang
- DH Davis
- DJ Foley
- DK Kiely
- DK Kiely
- DL Leslie
- DL Leslie
- EL Arbon
- EW Ely
- EW Ely
- F Bilotta
- FM Yang
- GL Weinhouse
- H Shigeta
- H Xie
- H Yamashita
- HM Wesselius
- IJ Zaal
- J Barr
- J Lu
- J Patel
- J Roggenbach
- JC Rodriguez
- JD Gaudreau
- JH Han
- JJ Dorsch
- JL Evans
- JL Martin
- JL Vincent
- JR Maldonado
- JS Durmer
- JS Seaman
- JW Thomason
- JY Gabor
- JY Gabor
- K Alagiakrishnan
- K Hatta
- K Olofsson
- KC Richards
- KC Richards
- KD Krewulak
- KE Schwab
- KJ Neufeld
- LM King
- M Dres
- M Thomas
- M van den Boogaard
- M van den Boogaard
- M Younes
- MA Barnes-Daly
- MA Mograss
- MA Pisani
- ME Smith
- MI Figueroa-Ramos
- MJ Schuurmans
- MM Ohayon
- MP Knauert
- N Zisapel
- NE Brummel
- NS Freedman
- NS Freedman
- NS Gooneratne
- P Pandharipande
- P Pandharipande
- P Pandharipande
- PG Shekelle
- PL Watson
- PP Pandharipande
- PT Trzepacz
- PT Trzepacz
- PT Trzepacz
- PT Trzepacz
- PW Kaplan
- R Elliott
- R Snyder-Halpern
- R Tamrat
- RC van der Mast
- RM Gupta
- RR Riker
- RS Bourne
- RS Friese
- S Ahmed
- S Balan
- S Celik
- S Dobing
- S Fisher
- S Grover
- S Ouimet
- S Vacas
- SJ Jaiswal
- SJT van Montfort
- SK Inouye
- SR Lewis
- SS Sultan
- T Al-Aama
- TA Jackson
- TD Girard
- TT Hshieh
- VJ Neelon
- VM Arora
- WD Schweickert
- X Drouot
- Y Harrison
- Y Shehabi
- Y Skrobik
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Aging studies of a polypropylene and natural rubber blend
- Author
- A Law
- A Thitithammawonga
- A Tidjani
- A Wal Van der
- A Wal Van der
- AK Jain
- AR Kamdar
- AS Hashim
- AV Shyichuk
- C Bendjaouahdou
- C Bendjaouahdou
- C Manleh
- EA Murillo
- FR Passador
- H Nabil
- H Nabil
- H Salamah
- I Abdullah
- I Kim
- J Pospisil
- JZ Liang
- K Jarukumjorn
- M Hernandez
- M Ichazo
- M Oksuz
- M Sain
- N Chandran
- N Lopattananon
- N Mohamad
- N Moussaif
- P Gijsman
- S Al-Malaika
- S Lipponen
- S Varghese
- W Wang
- XV Cao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of Acute Xanthine Oxidase Inhibition on Myocardial Energetics During Basal and Very High Cardiac Workstates
- Author
- A Boveris
- A Noman
- Abdul Mansoor
- AV Naumova
- BL Godber
- D Cesselli
- DA Siwik
- DC Wallace
- DC Wallace
- DF Rolfe
- DF Rolfe
- DR Green
- E Omerovic
- Forum Kamdar
- H Kogler
- HJ Lamb
- HJ Lamb
- HP Misra
- HR Schumacher Jr
- J George
- J Vina
- J Zhang
- J Zhang
- J Zhang
- Jianyi Zhang
- JM Hare
- Joseph Lee
- JP Manfredi
- K Kroll
- KK Griendling
- M Hou
- MA Becker
- MD Mayer
- N Chiamvimonvat
- N Kuzkaya
- PM Robitaille
- Qingsong Hu
- R IoLA
- RB Jennings
- RJ Bache
- SA Khan
- T Ukai
- U Landmesser
- UE Ekelund
- WF Saavedra
- Y Osada
- Y Takano
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
- Author
- A Agouni
- A Tesse
- AQ Truong-Tran
- AR Brash
- AR Hulsmann
- AV Peskin
- C Cerri
- C Pompeia
- C Pompeia
- C Yang
- C Yang
- C Yang
- CC Su
- Chun Yang
- CJ Noorden Van
- D Dymkowska
- Guoxiang Liu
- H Holmsen
- HA Mostefai
- I Kudo
- I Rahman
- IE Leon
- J Alijotas-Reig
- J Wang
- J Zimpelmann
- JS Kim
- K Komori
- KF Chung
- KL Simpson
- L Gallelli
- L Munoz Mde
- LC Huber
- M Tsoumakidou
- O Kamdar
- P Schonfeld
- PD Zalewski
- Pierre Hardy
- Q Qiu
- Qian Qiu
- S Martin
- S Mondal
- S Mortaza
- SA Comhair
- SF Mause
- T Hirabayashi
- T Maeno
- T Takahashi
- V Dengler
- VG Mahadevappa
- Wei Xiong
- WK Han
- X Qin
- X Wang
- Xiaoping Dan
- Xiaotian Dai
- Y Cheng
- Y Sun
- Yan Jiao
- Yang Xiang
- Zaixing Yang
- ZJ Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Nutrition and the Kidney
- Author
- A Gerber
- A Heidland
- A Hodgkinson
- AB Gutman
- AC Alfrey
- AJ Erslev
- AL Kaitz
- AL Linton
- AM Lewis
- AM Parfitt
- AV Kamdar
- B Finlayson
- B Rennick
- BEB Hyne
- BEC Nordin
- BM Brenner
- BN Bachra
- C Delaporte
- CE Dent
- CL Spannuth Jr.
- CM Radding
- CR Anand
- CYC Pak
- CYC Pak
- D Griffith
- DA Gibbs
- DA Goldstein
- DBN Lee
- DG Cramp
- DH Lawson
- DL Earnest
- DM Watkin
- DS David
- E Atkin-Thor
- E Feinstein
- E Hecking
- E Reisin
- EA Friedman
- ED Freis
- EE Owen
- EL Knapp
- ER Yendt
- ER Yendt
- ES Lyon
- FG Toback
- FJE Vajda
- FL Coe
- FL Coe
- G Schaeffer
- GA Rose
- GE Cartwright
- GM Berlyne
- H Fleisch
- H Fleisch
- H Jensen
- H Rasmussen
- H Rudolf
- H Spencer
- H-G Tiselius
- HA Feldman
- HA Guthrie
- HA Schroeder
- HC Gonick
- HE Ginn
- HE Williams
- HF DeLuca
- IFC McKenzie
- J Bergström
- J Lemann Jr.
- J Oliver
- J Parijs
- JB Lee
- JB Marsh
- JB Puschett
- JC Crawhall
- JC Jennette
- JD Blainey
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JD Kopple
- JE Seegmiller
- JF Maher
- JG Haddad Jr.
- JH Baxter
- JM Kalbfleisch
- JQ Stauffer
- JQ Stauffer
- JR Condon
- JW Coburn
- JW Dobbins
- KL Melmon
- L Recant
- L-O Norée
- LD Antoniou
- LD McBean
- LF Saldanha
- LH Smith
- LK Dahl
- LK Dahl
- LO Jacobson
- LS Ibels
- M Peacock
- M Walser
- M Walser
- MA Holliday
- MA Schalekamp
- MD Bogdonoff
- MH Briggs
- MJ Blumenkrantz
- MJ Phillips
- ML Sanfelippo
- MR Wills
- OE Owen
- OL Oke
- PH Henneman
- R Counahan
- R Kluthe
- R Rabkin
- RB Stott
- RC Muehrcke
- RE Randall Jr.
- RF Farquharson
- RF Pitts
- RF Pitts
- RH Rosenman
- RJ Glassock
- RM Abel
- RM Abel
- RM Abel
- RS Sherwin
- RW Gray
- S Cuttelod
- S Fukuda
- S Klahr
- S Klahr
- S Klahr
- S Margen
- SG Massry
- SG Massry
- SM Friedman
- SN Gershoff
- SN Gershoff
- SN Gershoff
- SR Faber
- TJ Runyan
- TN Pullman
- VU Collier
- W Kempner
- W Strober
- WC Thomas Jr.
- WD Davidson
- WD Kaehny
- WH Boyce
- WH Boyce
- Y Hayashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1979
- Field of study
The genetic landscape of cardiomyopathies
- Author
- A Behin
- A Bhonsale
- A Brodehl
- A Brodehl
- A Brodehl
- A Gulati
- A Heuser
- A Kimura
- A Kostareva
- A Milano
- A Rampazzo
- AAT Geisterfer-Lowrance
- AK Arndt
- AM Roberts
- AP Landstrom
- AR Belanger
- AV Postma
- AW Nugent
- B Gerull
- B Gerull
- B Gerull
- B Klauke
- B Mohapatra
- BE Stahli
- BJ Gersh
- BJ Maron
- BJ Maron
- BJ Maron
- BJ Maron
- BJ Maron
- BJ Maron
- BM Mayosi
- BS Budde
- C Andreasen
- C Geier
- C Rapezzi
- CJ Pua
- CY Ho
- D Brayson
- D Duboc
- D Erkapic
- D Fatkin
- D Fourey
- DM Bers
- DM Patel
- DS Herman
- E Arbustini
- E Grunig
- E Kayvanpour
- E Oechslin
- E Purevjav
- EE Norgett
- EG Kranias
- EM Green
- EM McNally
- EN Oechslin
- EP Kirk
- F Ichida
- F Ichida
- F Kamdar
- F Kirchner
- F Pasquale
- F Scaglia
- F Yuan
- F Zemrak
- FI Marcus
- FI Marcus
- FL Ruberg
- G Beffagna
- G Bonne
- G Luxan
- G McKoy
- G Millat
- G Quarta
- GR Abecasis
- H Ashrafian
- H Maatz
- H Milting
- H Niimura
- H Watkins
- HJ Worman
- I Olivotto
- IAW Rijsingen van
- J Finsterer
- J Grego-Bessa
- J Haas
- J Hengel van
- J Ingles
- J Mogensen
- J Mogensen
- J Romero
- JA Spudich
- JA Wong
- JJ McMurray
- JL Jefferies
- JM Lopez-Ayala
- JP Kaski
- JP Schmitt
- JP Tintelen van
- JR Golbus
- JR Golbus
- JR Weir-McCall
- K Kodo
- K Pilichou
- K Poetter
- KJ Green
- KL Turkowski
- L Bengtsson
- L Kober
- L Mestroni
- L Monserrat
- L Shan
- L Thierfelder
- L Xu
- LG Goldfarb
- LR Lopes
- M Bienengraeber
- M Franaszczyk
- M Hermida-Prieto
- M Kamisago
- M Olive
- M Pasotti
- M Petretta
- M Sata
- M Taylor
- M Vatta
- MA Burke
- MA Marques
- MA Simpson
- MB Codd
- MC Dalakas
- MJ Garcia
- ML Bang
- MR Taylor
- MW Wessels
- N Abrol
- N Protonotarios
- N Tiso
- ND Merner
- NG Mahon
- NR Alpert
- O Akinrinade
- O Akinrinade
- OE Nekrasova
- OJ Harrison
- P Charron
- P Charron
- P Elliott
- P Garcia-Pavia
- P Ouyang
- P Richard
- P Robinson
- P Robinson
- P Syrris
- PA Schweizer
- PA Zwaag van der
- PJ Guinto
- PM Elliott
- PS Andersen
- Q Xiong
- R Anan
- R Hastings
- R Jenni
- R Knoll
- R Ploski
- R Roncarati
- RB Sommerville
- RD Bagnall
- RE Hershberger
- RE Hershberger
- RE Hershberger
- RH Anderson
- RM Freedom
- RT Murphy
- S Bione
- S Brogna
- S Karam
- S Klaassen
- S Probst
- S Richards
- S Sasse-Klaassen
- S Schafer
- SB Bleyl
- SB Peddy
- SD Colan
- SE Kirschner
- SF Nagueh
- SH Vermij
- SJ Dijk van
- SK Kohli
- SP Harris
- SP Page
- SS Kushwaha
- ST Brescia
- T Arimura
- T Williams
- T Williams
- T Xu
- TK Chin
- V Fressart
- V Nikolova
- V Schulz
- VL Filatov
- W Guo
- W Wu
- WJ McKenna
- WP McNair
- X Chen
- Y Ma
- Y Peled
- YM Hoedemaekers
- YM Hoedemaekers
- YM Pinto
- Z Jahed
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/11/2019
- Field of study
Insights into genetic causes of cardiomyopathies have tremendously contributed to the understanding of the molecular basis and pathophysiology of hypertrophic, dilated, arrhythmogenic, restrictive and left ventricular noncompaction cardiomyopathy. More than thousand mutations in approximately 100 genes encoding proteins involved in many different subcellular systems have been identified indicating the diversity of pathways contributing to pathological cardiac remodeling. Moreover, the classical view based on morphology and physiology has been shifted toward genetic and molecular patterns defining the etiology of cardiomyopathies. Today, novel high-throughput genetic technologies provide an opportunity to diagnose individuals based on their genetic findings, sometimes before clinical signs of the disease occur. However, the challenge remains that rapid research developments and the complexity of genetic information are getting introduced into the clinical practice, which requires dedicated guidance in genetic counselling and interpretation of genetic test results for the management of families with inherited cardiomyopathies
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdollahi H
- Abdullah T
- Abecasis GR
- Abedalthagafi M
- Abul-Husn NS
- Acquilini D
- Adams EL
- Adamsara A
- Adeleye O
- Adra D
- Afilalo J
- Afilalo M
- Afrasiabi Z
- Agüero D
- Ahmadi S
- Akhtar S
- Aksentijevich A
- Al-Afghani H
- Al-Awdah L
- Alaamery M
- Alahmadey ZZ
- Alaverdian D
- Alavere H
- Albader A
- Albaiceta GM
- Albakri JK
- AlBardis H
- Albeladi M
- Albesher N
- Albrich W
- Albrich WC
- AlDhawi N
- Aleagha AE
- Alghamdi B
- Alghamdi J
- Ali A
- Aliannejad R
- Aljawini N
- AlJohani S
- Alkwai S
- Allos R
- AlMalik A
- Almalki F
- Almohammed I
- Almutairi M
- Alotaibi S
- Alowayn AM
- Alqahtani S
- Alqubaishi F
- Alrashed M
- Alshareef A
- Alsolm E
- Alswailm M
- AlZahrani D
- Amirsavadkouhi A
- Amitrano S
- Andolfo I
- Andretta F
- Andreucci E
- Andrews SJ
- Anedda F
- Anemoli V
- Angelantonio ED
- Annis A
- Antinori A
- Antoni MD
- Anwar M
- Arabi YM
- Arciero E
- Armstrong J
- Arning N
- Arranz MJ
- Arribas E
- Artuso R
- Arumugam P
- Ascolillo S
- Ashraf S
- Atkinson EG
- Aucella F
- Auld D
- Azarzar S
- Bachetti T
- Baillie JK
- Balaconis MK
- Baldassarri M
- Ball CA
- Baltzell AH
- Band G
- Bandini M
- Baraka D
- Baras A
- Baratti S
- Barbieri C
- Barda B
- Bargagli E
- Barhoush E
- Barnes KC
- Baroni S
- Bartels M
- Bassetti M
- Batini C
- Baya N
- Beck A
- Beckmann ND
- Bedini JL
- Bee CE
- Beguin Y
- Belbin GM
- Belhaj Y
- Beligni G
- Belisle A
- Belli MA
- Below J
- Benetti E
- Bennett D
- Bergantini L
- Bergomi P
- Berkowitz N
- Bernardo D
- Biagio AD
- Bianchi F
- Bibert S
- Bibert S
- Biesecker L
- Biscarini F
- Blay N
- Bochud M
- Bochud P-Y
- Bochud P-Y
- Bochud PY
- Bochud PY
- Boezen M
- Boillat N
- Boillat-Blanco N
- Bottà G
- Bouab M
- Boughton AP
- Bouras K
- Bradford Y
- Brahier T
- Brassard N
- Breen G
- Brenner B
- Britvan B
- Brumpton BM
- Bruno R
- Bruttini M
- Bryant S
- Bryant S
- Buring JE
- Busani S
- Bussotti M
- Butler-Laporte G
- Butterworth AS
- Buxbaum JD
- Caldarelli GP
- Callier S
- Cameli P
- Campbell A
- Campbell A
- Canaccini A
- Cantarini L
- Cantor MN
- Capasso M
- Capitani K
- Cappelli S
- Carella M
- Carey DJ
- Carreras A
- Carriero ML
- Castaño-Vinyals G
- Castelli F
- Castori M
- Catena E
- Caulfield MJ
- Ceri S
- Cerny A
- Chamnanphon M
- Chan G
- Chang X
- Chang X
- Chariyavilaskul P
- Charney AW
- Chasman DI
- Chassot J
- Chassé M
- Chaudhary K
- Chavan S
- Chen H-H
- Cheng N
- Chetruengchai W
- Chittoor G
- Cho JH
- Cho K
- Choi S
- Chowdhury M
- Chung R
- Churchhouse C
- Chwialkowska K
- Claassen S
- Claringbould A
- Clerc O
- Coignet M
- Coiro G
- Colligan G
- Collins BL
- Colobrán R
- Colombo R
- Conen A
- Conticini E
- Cordioli M
- Cordioli M
- Corridi M
- Cortés B
- Cossarizza A
- Coto E
- COVID-19 Host Genetics Initiative
- Coviello DA
- Croci L
- Croci S
- Crook DW
- Crooks K
- Crotti L
- Cullell N
- Curtis CJ
- Cusick C
- Cárcel-Márquez J
- Daga S
- Dalmau D
- Daly M
- Daly MJ
- Danesh J
- Darcis G
- Davis L
- Daya M
- de Cid R
- de Felipe Mimbrera A
- de geus EEJC
- de la Cal-Sabater P
- DeDiego ML
- Deelen P
- Dei S
- Deloukas P
- Desanctis E
- Desgranges F
- di Bartolomeo C
- Dietl B
- Do R
- Dobaño C
- Doddato G
- Domenico PD
- Domingo C
- Domínguez-Mayoral A
- Donati A
- Donner K
- Durand M
- Durham C
- D’Acremont V
- D’Alessandro M
- D’Arminio Monforte A
- D’Mellow K
- Earle SG
- Egger T
- Eid MA
- El-Jawhari JJ
- El-Lawaty WM
- El-shanshory MR
- El-Sherbiny YM
- Elhadidy TA
- Elnagdy MH
- Eltoukhy MM
- Emiliozzi A
- Emma D
- Erard V
- Erard V
- Esko T
- Estoppey Younes S
- Fabbiani M
- Falcone M
- Fallerini C
- Farré X
- Fava F
- Fawns-Ritchie C
- Fawns-Ritchie C
- fawzy MS
- Felemban WA
- Feng Y-CA
- Feri M
- Fernandez-Cadenas I
- Ferreira MAR
- Ferri C
- Filipovic M
- Filippidis P
- Finer S
- Finer S
- Finucane H
- Fiorentino G
- Fiz-López A
- Forgetta V
- Foucras S
- Fowler T
- Franchi F
- Francisci D
- Franco G
- Franke L
- Frediani B
- Free RC
- Frenckell CV
- Friolet R
- Frippiat F
- Frischknecht M
- Frithiof R
- Frullanti E
- Furini S
- Gabbi C
- Gabrieli A
- Gaddis M
- Galván-Femenía I
- Ganna A
- Garcia-Aymerich J
- García-Clemente M
- García-Madrona S
- Gass MC
- Gatti F
- Gaziano JM
- Georges M
- Gettler K
- Ghosh B
- Giannattasio F
- Gignoux CR
- Giliberti A
- Giorli A
- Giot J-B
- Girardis M
- Girshick A
- Glessner JR
- Glessner JT
- Gofflot S
- Goldstein JI
- Gomez J
- Gonseth Nussle S
- González-Villa E
- Gori M
- Grassi D
- Green RC
- Griffiths C
- Griffiths CJ
- Grip J
- Guarnaccia A
- Guerrini S
- Guidelli L
- Guillet A
- Guindo-Martinez M
- Guiot J
- Guntz J
- Gupta R
- Guturu H
- Guyat-Jacques C
- Guyatt AL
- Guzman C
- Guéry B
- Haefliger D
- Hakonarson H
- Hakonarson H
- Halawani RT
- Harerimana N
- Harris JR
- Harthi FA
- Hasanato R
- Hayward C
- Hayward C
- Hegazy MAF
- Helgeland Ø
- Henry D
- Hensen K
- Hiester LL
- Hirankarn N
- Ho Y-L
- Hoggart C
- Hollox EJ
- Hong EL
- Horowitz JE
- Hosseini A
- Hottenga JJ
- Huang QQ
- Huang QQ
- Huckins LM
- Huffman JE
- Hultström M
- Hunt KA
- Hunt KA
- Hurles M
- Hussain S
- Huynen P
- Hveem K
- Hügli O
- Iglesias LL
- Ikram MA
- Iolascon A
- Islam K
- Itan Y
- Jacques J
- Jantarabenjakul W
- Jaquet M
- Jiménez-Xarrié E
- John C
- Jordan DM
- Josyula NS
- Jung J
- Justice AE
- Kahlert CR
- Kallaste A
- Kamdar D
- Kamdar D
- Kampouri EE
- Kanai M
- Kanai M
- Karczewski KJ
- Karjalainen J
- Karlson EW
- Karp A
- Kaufmann DE
- Kaunisto M
- Keller K
- Kenny EE
- Kerchberger VE
- Kerr SM
- Khafaga WT
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- Sesso HD
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- Shotelersuk V
- Shrine N
- Siano M
- Sloofman LG
- Smieszek SP
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- Smoller JW
- Sobh A
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- Spector TD
- Spencer CCA
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- Tamm A
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- Tenesa A
- Thompson RC
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- Timmers PRHJ
- Tiseo G
- Tita R
- Tobin MD
- Tommasi A
- Torky MS
- Torrents D
- Torvorapanit P
- Trankiem A
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- Trembath RC
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- Trivedi B
- Trogstad L-IS
- Trotta T
- Tsao P
- Tschopp J
- Tselios C
- Tsuo K
- Tumbarello M
- Turley P
- Uitterlinden AG
- Underwood SJ
- Vaghi M
- Valente S
- Valentino F
- van Blokland I
- van Heel D
- van Heel DA
- van Heel DA
- Van Singer M
- Vecchia M
- Veerapen K
- Venn LD
- Venturelli S
- Vergori A
- Verma A
- Verma SS
- Verzuri A
- Viala B
- Villalonga JM
- Vincenti A
- Viollet RM
- Vivo OD
- Voide C
- Voide C
- Vollenweider P
- Vollenweider P
- von Hohenstaufen KA
- von Mering C
- Vonk JM
- Vulesevic B
- Wain LV
- Walker S
- Walters RK
- Wang J
- Wang X
- Wanying Z
- Warmerdam R
- Weiss ST
- Wicks SJ
- Willer C
- Williams AT
- Wilson DJ
- Wilson JF
- Wolford B
- Wolford B
- Wolford B
- Woolley AE
- Wozniak H
- Wright J
- Wright J
- Wyllie DH
- Xue X
- Yadav A
- Yassen AM
- Zanella I
- Zeberg H
- Zguro K
- Zhang M
- Zhao JH
- Zhou W
- Zhou W
- Zlatopolsky M
- zu Bentrup FM
- Zucchi P
- Zyndorf M
- Zöllner S
- Åsvold BO
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
- Author
- Abalos-Galito M
- Abboy C
- Abrahamian F
- Abreu E
- Ackerman If
- Acosta Ia
- Adams L
- Adaoag Aa
- Adiaz-Baui Tt
- Aggarwal Nk
- Aguilar Dominguez Pe
- Aguilar-Orozco Ra
- Aguirre Sosa I
- Ahmed M
- Aleksandrova E
- Alekseeva E
- Alexandrescu Ds
- Ali Mi
- Allen GG Jr
- Allen Dr
- Allison Dc
- Altieri Hh
- Alvey Jc
- Alwine Lk
- Amer L
- Anand S
- Andrasofszky Z
- Anspach Rb
- Antuni Jd
- Antépara Ercoreca I
- Anwar J
- Apaliski Sj
- Arastu Rs
- Aries Sp
- Arimah C
- Arnedillo Muñoz A
- Arora Cm
- Arthur Cp
- Asherova I
- Auerbach D
- Austri Investigators
- Azzam Sj
- Babyesiza A
- Backer V
- Badar FL 3rd
- Badat A
- Baker Jw
- Balakrishnan K
- Balthazar Y
- Banovcin P
- Barasch Jp
- Barbarash Ol
- Barbe Illa F
- Barber Ma
- Bardin Pg
- Bardinas-Rodriguez R
- Barnes Nc
- Barreiro López B
- Barreiro Tj
- Barros Monge Mj
- Barth D
- Bartha A
- Bartuzi Z
- Bassa A
- Bauler A
- Baumbach Rr
- Baur Ce
- Baxter Bs
- Beach Jl
- Beasley Rl
- Beavins Je
- Beliveau Wj
- Benbow Mj
- Benedix A
- Bennett Nl
- Bennett Rl
- Berenfus Vi
- Berg P
- Bergna Ma
- Bergtholdt B
- Bernal H
- Bernan Ap
- Bernstein Di
- Besh L
- Bettig U
- Bielous-Wilk A
- bin Abdul Aziz Fa
- Bindig Hw
- Blaiss Ms
- Blanco Aparicio M
- Blumenthal Kw
- Boada Valmaseda A
- Boas Sr
- Bolivar Grimaldos F
- Bolliger Ct
- Bonavia M
- Borders Jl
- Boscia Ja
- Bosque García M
- Botzen U
- Boulware Wn
- Bowling Bt
- Bożek A
- Brabec Ba
- Braga M
- Bramlet Dg
- Brautigam Df
- Breedt J
- Brehler R
- Breyer Go
- Brown V
- Brownell Jm
- Bruce Tr
- Bruckhaus-Walter M
- Bruning A
- Brzostek J
- Buaron Ks
- Bugrova O
- Bukreeva Eb
- Buresova M
- Burhan H
- Bursova J
- Bustamante Ruiz A
- Butkovic-Tomljanovic R
- Błażowski Ł
- Call Rs
- Calvo Gil Ma
- Campbell Ca
- Canaan Ya
- Cannon Df
- Carpio Jm
- Carretero Anibarro P
- Carroll Pa
- Castillo Hofer Cr
- Cathcart Ws
- Cerveri I
- Cevallos Jp
- Chapman Kr
- Chaudhuri R
- Chauhan Av
- Cheng Sl
- Chermenskiy A
- Chern Jh
- Chetta Aa
- Chevalier D
- Chiu Mh
- Chizhova O
- Choi I
- Chomiciene A
- Chorostowska-Wynimko J
- Christensen J
- Christensen Ta
- Christina Mo
- Chrzanowski Rr
- Chuang Rb
- Chung Cl
- Ciekalska K
- Cieslicki J
- Cirule I
- Cisneros Am
- Civitarese Fa
- Clark Jp
- Clements Bs
- Clifford Dp
- Coggi Ja
- Cohen Kr
- Collier D
- Collins Bg
- Collins H
- Comellas A
- Condit J
- Cordasco EM Jr
- Corder Cn
- Covar Ra
- Coverston Kd
- Crimi N
- Croce Sa
- Cruz H
- Csanadi Ma
- Cuadrado Ja
- Curtis Ct
- Cutrera R
- Daftary Pk
- Dalan D
- Dalawari Sp
- Daly Wc
- Dapper T
- Daud M
- Davies Ej
- Davis Kc
- Davoliene I
- Dawes Kw
- De Gennaro Ms
- De Rosa M
- De Valle Ol
- Decotiis Ba
- Del Campo Matias F
- Deluca Rf
- Demko I
- Desantis Dm
- Dhillon R
- Diaz Amor Pv
- Diaz Jd
- Diaz Jl
- Dice Jp
- Dimitrova R
- Dimova D
- Diogo Jj
- Dixon C
- Djajalaksana S
- Dobkin La
- Dobrusin Rs
- Dopudja Pantic V
- Dore Nd
- Dransfield Mt
- Dudnyk O
- Duka Kd
- Dupont Lj
- Ebbeling Wl
- Echave-Sustaet Jm
- Eckhard Jg
- Edwards Jd
- Eglite R
- Elacion Jm
- Elizalde A
- Elkayam D
- Ellery A
- Ellis Gc
- Ellison Wt
- Elsen Jr
- Emanuel S
- Emeryk A
- Emmett Ah
- Engel Lr
- Engelhard R
- Ensz Dj
- Ericksen Cl
- Ervin Je
- Espinosa de los Monteros Garde Mj
- Esposito S
- Estrella Viladegut Ra
- Evdokimova A
- Fang C
- Farkas M
- Farrah Vb
- Fazio Lizandrelo Cl
- Feldmeyer F
- Field Jd
- Figueroa Dp
- Fishman Hj
- Fissan H
- Fitzgerald Da
- Florea R
- Focauld F
- Focil A
- Folcik K
- Foresi A
- Forstner B
- Fouche Lf
- Franco MA Jr
- Frandsen Br
- Franz Kh
- Fratrik J
- Frick Bs
- Fulat Ma
- Funck J
- Fushtey Im
- Gammeri E
- Gani M
- Ganti K
- Garcia Hernandez Gm
- Garcia Fl
- Garmash N
- Garscadden Ag
- Garza-Salinas S
- Gatti Ea
- Gattolin G
- Gawlik R
- Gałuszka-Bilińska A
- Gellady Am
- George Ar
- Gessner Cm
- Gibbon Gw
- Giejlo M
- Ginko T
- Giorgadze Ml
- Gleason Gp
- Godlevska O
- Goldberg P
- Goldstein Mf
- Gonzalez Ge
- Gosn Am
- Gower Rg
- Grande Ja
- Gregory D
- Grigat Ce
- Grigoryev S
- Grimm-Sachs V
- Griskeviciene V
- Groth G
- Grubb Sd
- Guthrie Rp
- Guttlerova E
- Gömöri K
- Haas Ta
- Haft Ks
- Hajal R
- Hamelmann E
- Hammond Gd
- Hampf J
- Hanf G
- Hansel Nn
- Hansen Vr
- Harat R
- Harris Af
- Hartman An
- Hartman P
- Harvey Rr
- Havasi-Jost G
- Hazan-Steinberg S
- Headley Dm
- Hegedus-Jungvirth M
- Heigerick Gc
- Heinz Gu
- Heller Bn
- Helm K
- Hendrix El
- Henein S
- Herrod Jn
- Hewitt Mj
- Hines Rl
- Hirdt Ap
- Hirschfield Ja
- Hoeltz S
- Hoffman Ks
- Hofman T
- Hofmann S
- Hogan Ad
- Horvathova H
- Hosler Mr
- Hospodarskyy I
- Howland Wc
- Hsu Cc
- Hsu Fj
- Hubbard Wm
- Hudson Jd
- Huffman C
- Hussain M
- Iashyna L
- Idrisova E
- Iemoli E
- Ioachimescu Oc
- Irkhina I
- Ismail Ai
- Ismail Ms
- Ismail Ym
- Ivkovic-Jurekovic I
- Jaffrani Na
- Jahnz-Różyk K
- Jander R
- Jandl M
- Jasch-Hoppe B
- Jedrzejczak M
- Jiang N
- Jirmanova I
- Johnsen Cr
- Jones Sw
- Jordan Rs
- Joshi Ke
- Jung T
- Junggeburth Jj
- Jurgens Jc
- Kaashmiri Mw
- Kachel T
- Kaik G
- Kaladze M
- Kalafer M
- Kalina P
- Kamdar Ba
- Kamiński D
- Kanuga Jg
- Kao Nl
- Karako P Sr
- Kardos P
- Karetzky M
- Katsetos Jc
- Kay Js
- Kelly Aj
- Kelm Warchol A
- Khurkhurova Nv
- Khvelos Si
- Kim C
- Kim Js
- Kim Wj
- Kimmel Ma
- Kimura Sh
- Kingsley Jk
- Kirstein Jl
- Kis S
- Kissyova Ibrishimova G
- Kleerup Ec
- Klein Rm
- Knueppel W
- Koch T
- Koeberl Gh
- Koh Dw
- Koh Yy
- Kohli N
- Kolman P
- Kolorz C
- Kondyurina Eg
- Konieczny Z
- Korduan M
- Korth-Wiemann B
- Kostin Vi
- Kostromina Vp
- Koura Fa
- Kovacs Sp
- Krakhmalova O
- Kral Km
- Krasko Mp
- Kratzer J
- Kreit Ci
- Kreutter Fm
- Krezdorn Hg
- Kroker A
- Kruell M
- Kryuchko T
- Kubicki Tm
- Kucera M
- Kudelya L
- Kuehne P
- Kulynych Ov
- Kwasniewski A
- Kwok S
- Kwon Ss
- Labuda Jm
- Lai Rs
- Laleko Sl
- Lam As
- Lapidus Rj
- Lara Mm
- Larrateguy Ld
- Latorre Aj
- Lechin Ae
- Lee Jj
- Lee Md
- Lee S
- Lee Sh
- Lee Sk
- Lee Wm
- Legnani Dl
- Lenk U
- Lenney W
- Lenskaya L
- Lentnek Al
- Lenz Jj
- Lesh Kw
- Leszczyński W
- Levashov S
- Levchenko O
- Levins Pf
- Levinsky Dm
- Lezana Soya V
- Liefring E
- Liem Jj
- Lillestol Mj
- Lim H
- Lin Ck
- Litvinova T
- Liu Yc
- Livezey Md
- Lloyd-Turney Cw
- Loboshka Becheva M
- Lockey Rf
- Logvinenko N
- Long Ra
- Lores Obradors L
- Lougheed Md
- Lowe Dw
- Luengo Planas Mt
- Luisetti M
- Lynch Mj
- López Viña A
- Macgillivray Bk
- Machkovska M
- Madjarov S
- Mahadevan Kp
- Mahmood Sm
- Major K
- Makam Sk
- Maloney Mj
- Maltbaek N
- Mandazhieva Pepelanova M
- Mapel D
- Marcipar Am
- Margolis Bd
- Margulies J
- Martin Ee
- Martin Ef
- Martinot Jb
- Martynov A
- Mascolo M
- Maspero Jf
- Mataria H
- Mathur Rn
- Matsuno Fuchigami A
- Mattar Pn
- Maynard Km
- Maynard N
- Mccormick B
- Mcelya M
- Mcevoy Ce
- Mckenzie Wc
- Md Kassim Rm
- Medina Iv
- Medwedeff Le
- Mehta Kd
- Melamed Ir
- Meli Jv
- Merke J
- Merrick Bh
- Meyers Pj
- Mezei M
- Michetti G
- Micke L
- Miller Bt
- Mincewicz G
- Minton Sm
- Miranda Fg
- Mitic Milikic M
- Mitlehner W
- Mizernitski Y
- Mohar De
- Mohd Fadzli Fb
- Monsó Molas E
- Montenegro Ch
- Morris Fa
- Morrison Bs
- Moss Mh
- Mueller H
- Munoz F
- Mészáros I
- Nadaskic R
- Naidenova I
- Naini Gr
- Nakamura Ct
- Naseeruddin S
- Nassim C
- Naudts If
- Naudziunas A
- Naudziunas S
- Navarro Dourdil A
- Navazo Lj
- Nayyar S
- Neamtu Ml
- Nell H
- Nemtsov B
- Nestorovic B
- Neumann G
- Nieto García Aj
- Nieuwoudt G
- Niezgoda K
- Ninane V
- Nissim Je
- Noleva K
- Noor F
- Nordstrom M
- Norman D
- Novozhenov Vg
- O'Connor Tm
- Oberoi Ms
- Offenberger J
- Oldenburg W
- Olszewska-Ziąber A
- Onasz-Manitius M
- Onia Af
- Orr Rr
- Osea Ea
- Overlack A
- Paine Wj
- Palatnik M
- Pandya Hc
- Pangtay D
- Panina Ss
- Panuto Ja
- Panzer F
- Park Cs
- Parker Iw
- Pascoe Sj
- Pasiyeshvili Lm
- Pastorello Ea
- Patel M
- Pavlishchuk S
- Pawlukiewicz M
- Peché R
- Perera Ms
- Perez Chada Rd
- Perez A
- Perpina Tordera M
- Pesci A
- Peters PH Jr
- Petrova I
- Picado Valles C
- Pilette C
- Pimentel SM Jr
- Piotrowicz P
- Piotrowski W
- Pisarczyk-Bogacka E
- Piskorz P
- Pistolesi M
- Plutinsky J
- Pluto Tm
- Poga M
- Pollock Mt
- Popova Vv
- Posner Ls
- Povysilova L
- Pratt Se
- Pravda P
- Prazma Cm
- Pribulova E
- Pritchard Jc
- Prokop-Staszecka A
- Prystupa Ln
- Pudi Kk
- Puig Cm
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- Qaqundah Py
- Quilodran Silva Cn
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- Rahman St
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- Raikhel M
- Raissy Hh
- Rajakulasingam K
- Rakvacs M
- Ramirez-Diaz Sp
- Ramstad Ds
- Ranasinghe Es
- Rangel Os
- Raphiou Ih
- Rapo Se
- Raschal Sp
- Rasmussen Nl
- Reddy Dg
- Rehman Sm
- Reinholz N
- Remppis R
- Reshetko Ov
- Reyes Sr
- Rhodes Rb
- Riegel P
- Riffer E
- Rihal Ps
- Riley ED 4th
- Riva E
- Rizvi Q
- Robinson Pd
- Robinson Pj
- Rodriguez Alvarez Mdel M
- Rodriguez Dh
- Rogers Cm
- Rohlf Jl
- Romaniuk Li
- Romano A
- Romeu H
- Roney Cw
- Ronsick So
- Rosen Jb
- Roslan A
- Rowe Ms
- Rudzeviciene O
- Rueckert P
- Ruoff Ge
- Russo Ma
- Ryan Eh
- S-Naval S
- Saff Rh
- Saini N
- Sajkov D
- Samuels Bs
- Samuelson Rj
- Sandagon Mj
- Saniuk Rj
- Sargeant Wo
- Saunders Mk
- Saura Vinuesa A
- Saway W
- Scarupa Md
- Schaetzl Rj
- Schauer U
- Schear Mj
- Schenkenberger I
- Schlegel V
- Scholz G
- Schroers M
- Schwarz Cm
- Schwittay A
- Scichilone N
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- Seddon P
- Segall N
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- Seidner Mr
- Seifer Fd
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- Serra Batlles J
- Setijadi Ar
- Setyanto Db
- Shah Ms
- Shah Sb
- Shapero Pa
- Sharma R
- Shearer Sd
- Sheikh Sq
- Shepherd Ts
- Sher Er
- Sher Ld
- Sherenkov A
- Shirinsky Vs
- Short Bh
- Shpagina L
- Siddique N
- Silas Pe
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- Ziora D
- Zlatos A
- Zubarenko O
- Zykov K
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND:
The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate.
METHODS:
In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of life-threatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone-salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation.
RESULTS:
Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone-salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthma-related event in the fluticasone-salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P=0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthma-related intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone-salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone-salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P<0.001).
CONCLUSIONS:
Patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. Patients receiving fluticasone-salmeterol had fewer severe asthma exacerbations than did those in the fluticasone-only group
Mapping the human genetic architecture of COVID-19
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- Volland S
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- Vollenweider P
- Von Frenckell C
- von Hohenstaufen K
- von Mering C
- Vonk JM
- Voza A
- Vulesevic B
- Vuylsteke A
- Vuylsteke A
- Wacker EM
- Wackett T
- Wadams B
- Waddington N
- Waddy S
- Wagstaff V
- Waite AAC
- Wakabayashi A
- Wakahara K
- Wake R
- Wakefield P
- Wakinshaw F
- Walden A
- Waldron J
- Walker D
- Walker R
- Walker S
- Walker S
- Walker S
- Wall A
- Walsh T
- Walter J
- Walters RK
- Walton O
- Wang B
- Wang C
- Wang H
- Wang J
- Wang Q
- Wang X
- Wang X
- Ward G
- Ward K
- Ward L
- Ward M
- Warden S
- Warmerdam R
- Warren D
- Washington NL
- Wassall H
- Wasson C
- Watanabe H
- Watanabe K
- Watson E
- Watson G
- Watson J
- Watson N
- Watters M
- Waugh V
- Weaver J
- Webster A
- Webster D
- Webster K
- Wei S
- Weiss ST
- Weldon CH
- Wells C
- Welters I
- Welters ID
- Wendorff M
- Wendt FR
- Wery M
- Wesse T
- West J
- Weston H
- Wham M
- Wheeler M
- Whileman A
- Whitbread J
- White D
- White I
- White K
- White M
- White N
- White S
- Whitehouse T
- Whiteley S
- Whiteside J
- Whittaker P
- Whittington A
- Whittle H
- Whitton C
- Whyte C
- Wicks SJ
- Wienbrandt L
- Wiersinga WJ
- Wijesinghe M
- Wilby E
- Wilcock E
- Wilcox L
- Wilcox R
- Wild H
- Wild L
- Wild L
- Wilding L
- Wiles M
- Wilfling S
- Wilkin F
- Wilkins J
- Wilkinson A
- Wilkinson B
- Willer CJ
- Williams A
- Williams A
- Williams A
- Williams D
- Williams F
- Williams G
- Williams H
- Williams K
- Williams M
- Williams M
- Williams P
- Williams S
- Williams T
- Willis H
- Wills M
- Willson J
- Wilson A
- Wilson DJ
- Wilson J
- Wilson JF
- Wilson L
- Winchester S
- Winnard S
- Winter-Goodwin B
- Wiselka M
- Wittig M
- Witzke O
- Wolf-Roberts R
- Wolford B
- Wolford B
- Wolterman RA
- Wolverson A
- Wong J
- Wood D
- Wood H-L
- Wood S
- Wood T
- Woodford C
- Woodruff M
- Woods L
- Woodyatt W
- Woolley AE
- Wooton DG
- Working UCLAHATLASDM
- Workman A
- Worner R
- Worsley L
- Wouters D
- Wozniak H
- Wray G
- Wren L
- Wright D
- Wright J
- Wright J
- Wright M
- Wrobel N
- Wrobel N
- Wu Y
- Wulandari R
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yadav A
- Yagi K
- Yamada M
- Yamada Y
- Yamagata K
- Yamasaki M
- Yang G
- Yang J
- Yang Z
- Yaspan B
- Yasui Y
- Yates B
- Yates B
- Yatomi M
- Ye C
- Yengo L
- Yermakovich D
- Yi X
- Yonekawa A
- Yoon H
- Yoon KJ
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Youlton N
- Younes SE
- Young P
- Yun N
- Zak A
- Zaki A
- Zambon M
- Zamikula J
- Zanella A
- Zanella I
- Zanelli G
- Zara F
- Zara F
- Zarate R
- Zarate R
- Zborowski AC
- Zeberg H
- Zechner M
- Zechner M
- Zguro K
- Zhai R
- Zhang JE
- Zhang M
- Zhao JH
- Zhen J
- Zheng C
- Zheng T
- Zhou W
- Zhou W
- Zhu W
- Zitter L
- Zlatopolsky M
- Zoller H
- Zollner S
- Zongo O
- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease