29 research outputs found
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Formation of low-energy antihydrogen
Antihydrogen atoms, produced near rest, trapped in a magnetic well, and cooled to the lowest possible temperature (kinetic energy) could provide an extremely powerful tool for the search of violations of CPT and Lorentz invariance. The author describes plans to trap antiprotons and positrons in a combined Penning trap and to form a significant number of cold antihydrogen atoms for comparative precision spectroscopy of hydrogen and antihydrogen
A highly virulent variant of HIV-1 circulating in the Netherlands
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log(10) increase (i.e., a similar to 3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination. with increased transmissibility and an unfamiliar molecular mechanism of virulence.Peer reviewe
Physics with antihydrogen
Performing measurements of the properties of antihydrogen, the bound state of an antiproton and a positron, and comparing the results with those for ordinary hydrogen, has long been seen as a route to test some of the fundamental principles of physics. There has been much experimental progress in this direction in recent years, and antihydrogen is now routinely created and trapped and a range of exciting measurements probing the foundations of modern physics are planned or underway. In this contribution we review the techniques developed to facilitate the capture and manipulation of positrons and antiprotons, along with procedures to bring them together to create antihydrogen. Once formed, the antihydrogen has been detected by its destruction via annihilation or field ionization, and aspects of the methodologies involved are summarized. Magnetic minimum neutral atom traps have been employed to allow some of the antihydrogen created to be held for considerable periods. We describe such devices, and their implementation, along with the cusp magnetic trap used to produce the first evidence for a low-energy beam of antihydrogen. The experiments performed to date on antihydrogen are discussed, including the first observation of a resonant quantum transition and the analyses that have yielded a limit on the electrical neutrality of the anti-atom and placed crude bounds on its gravitational behaviour. Our review concludes with an outlook, including the new ELENA extension to the antiproton decelerator facility at CERN, together with summaries of how we envisage the major threads of antihydrogen physics will progress in the coming years
Mitigation strategies against radiation-induced background for space astronomy missions
The Advanced Telescope for High ENergy Astrophysics (ATHENA) mission is a major upcoming space-based X-ray observatory due to be launched in 2028 by ESA, with the purpose of mapping the early universe and observing black holes. Background radiation is expected to constitute a large fraction of the total system noise in the Wide Field Imager (WFI) instrument on ATHENA, and designing an effective system to reduce the background radiation impacting the WFI will be crucial for maximising its sensitivity. Significant background sources are expected to include high energy protons, X-ray fluorescence lines, `knock-on' electrons and Compton electrons. Due to the variety of the different background sources, multiple shielding methods may be required to achieve maximum sensitivity in the WFI. These techniques may also be of great interest for use in future space-based X-ray experiments. Simulations have been developed to model the effect of a graded-Z shield on the X-ray fluorescence background. In addition the effect of a 90nm optical blocking filter on the secondary electron background has been investigated and shown to modify the requirements of any secondary electron shielding that is to be used
Positron plasma diagnostics and temperature control for antihydrogen production
Production of antihydrogen atoms by mixing antiprotons with a cold, confined,
positron plasma depends critically on parameters such as the plasma density and
temperature. We discuss non-destructive measurements, based on a novel,
real-time analysis of excited, low-order plasma modes, that provide
comprehensive characterization of the positron plasma in the ATHENA
antihydrogen apparatus. The plasma length, radius, density, and total particle
number are obtained. Measurement and control of plasma temperature variations,
and the application to antihydrogen production experiments are discussed.Comment: 5 pages, 4 figures, to be published in Phys. Rev. Let
ATHENA -- First Production of Cold Antihydrogen and Beyond
Atomic systems of antiparticles are the laboratories of choice for tests of
CPT symmetry with antimatter. The ATHENA experiment was the first to report the
production of copious amounts of cold antihydrogen in 2002. This article
reviews some of the insights that have since been gained concerning the
antihydrogen production process as well as the external and internal properties
of the produced anti-atoms. Furthermore, the implications of those results on
future prospects of symmetry tests with antimatter are discussed.Comment: Proc. of the Third Meeting on CPT and Lorentz Symmetry, Bloomington
(Indiana), USA, August 2004, edited by V. A. Kostelecky (World Scientific,
Singapore). 10 pages, 5 figures, 1 table. Author affiliations cor
Cold-Antimatter Physics
The CPT theorem and the Weak Equivalence Principle are foundational
principles on which the standard description of the fundamental interactions is
based. The validity of such basic principles should be tested using the largest
possible sample of physical systems. Cold neutral antimatter (low-energy
antihydrogen atoms) could be a tool for testing the CPT symmetry with high
precision and for a direct measurement of the gravitational acceleration of
antimatter. After several years of experimental efforts, the production of
low-energy antihydrogen through the recombination of antiprotons and positrons
is a well-established experimental reality. An overview of the ATHENA
experiment at CERN will be given and the main experimental results on
antihydrogen formation will be reviewed.Comment: Proceedings of the XLIII International Meeting on Nuclear Physics,
Bormio (Italy), March 13-20 (2005). 10 pages, 4 figures, 1 tabl
A highly virulent variant of HIV-1 circulating in the Netherlands
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log(10) increase (i.e., a similar to 3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination. with increased transmissibility and an unfamiliar molecular mechanism of virulence