83 research outputs found
Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells
Glucocorticoids play an important role in the treatment of a number of
hematological malignancies, such as multiple myeloma. The effects of
glucocorticoids are mediated through the glucocorticoid receptor alpha,
the abundance of which can be modulated by alternative splicing of the
glucocorticoid receptor mRNA. Two splice variants of the glucocorticoid
receptor mRNA have been described: glucocorticoid receptor beta, which
reportedly has a dominant negative effect on the actions of the
glucocorticoid receptor alpha, and glucocorticoid receptor P, of which the
effects are unknown. In this study, we have investigated the expression
levels of these two splice variants at the mRNA level in multiple myeloma
cells and in a number of other hematological tumors. Although the
glucocorticoid receptor beta mRNA was, if at all, expressed at very low
levels, considerable amounts (up to 50% of the total glucocorticoid
receptor mRNA) glucocorticoid receptor P mRNA was present in most
hematological malignancies. In transient transfection studies in several
cell types and in multiple myeloma cell lines, the glucocorticoid receptor
P increased the activity of the glucocorticoid receptor alpha. These
results suggest that the relative levels of the glucocorticoid receptor
alpha and the glucocorticoid receptor P may play a role in the occurrence
of glucocorticoid resistance in tumor cells during the treatment of
hematological malignancies with glucocorticoids
How to move ionized gas: an introduction to the dynamics of HII regions
This review covers the dynamic processes that are important in the evolution
and structure of galactic HII regions, concentrating on an elementary
presentation of the physical concepts and recent numerical simulations of HII
region evolution in a non-uniform medium.
The contents are as follows:
(1) The equations (Euler equations; Radiative transfer; Rate equations; How
to avoid the dynamics; How to avoid the atomic physics).
(2) Physical concepts (Static photoionization equilibrium; Ionization front
propagation; Structure of a D-type front; Photoablation flows; Other
ingredients - Stellar winds, Radiation pressure, Magnetic fields,
Instabilities).
(3) HII region evolution (Early phases: hypercompact and ultracompact
regions; Later phases: compact and extended regions; Clumps and turbulence).Comment: To be published as a chapter in 'Diffuse Matter from Star Forming
Regions to Active Galaxies' - A volume Honouring John Dyson. Eds. T. W.
Harquist, J. M. Pittard and S. A. E. G. Falle. 25 pages, 7 figures. Some
figures degraded to meet size restriction. Full-resolution version available
at http://www.ifront.org/wiki/Dyson_Festschrift_Chapte
Massive Star Formation
This chapter reviews progress in the field of massive star formation. It
focuses on evidence for accretion and current models that invoke high accretion
rates. In particular it is noted that high accretion rates will cause the
massive young stellar object to have a radius much larger than its eventual
main sequence radius throughout much of the accretion phase. This results in
low effective temperatures which may provide the explanation as to why luminous
young stellar objects do not ionized their surroundings to form ultra-compact H
II regions. The transition to the ultra-compact H II region phase would then be
associated with the termination of the high accretion rate phase. Objects
thought to be in a transition phase are discussed and diagnostic diagrams to
distinguish between massive young stellar objects and ultra-compact H II
regions in terms of line widths and radio luminosity are presented.Comment: 21 pages, 6 figures, chapter in Diffuse Matter from Star Forming
Regions to Active Galaxies - A Volume Honouring John Dyson, Edited by T.W.
Hartquist, J. M. Pittard, and S. A. E. G. Falle. Series: Astrophysics and
Space Science Proceedings. Springer Dordrecht, 2007, p.6
Controle associado de Alphitobius diaperinuse efeito de microrganismos eficazes no desenvolvimento de Beauveria bassiana
O objetivo deste trabalho foi avaliar a eficiência de Beauveria bassiana (Bb), terra diatomácea (TD) e microrganismos eficazes (EM-4), associados ou não, no controle de Alphitobius diaperinus, e o efeito de EM-4 no desenvolvimento de B. bassiana. Os agentes de controle (Bb, TD e EM-4), em diferentes concentrações e combinações, foram aplicados em uma mistura de cama-de-frango e ração, em que os insetos foram acondicionados por dez dias. Avaliaram-se, in vitro: a germinação, as unidades formadoras de colônia (UFC), o crescimento vegetativo e a produtividade de conídios de Bb em contato com suspensão aquosa de EM-4 (1%) não filtrada e filtrada. Os maiores índices de mortalidade foram observados nos tratamentos TD + Bb + EM-4 e TD + Bb, nas maiores concentrações. Verificou-se efeito não-aditivo sinérgico para TD + Bb nas três concentrações. Nos testes com EM-4 filtrado, não houve diferença em relação à testemunha quanto à germinação e às UFC, entretanto, o crescimento vegetativo e a produtividade de conídios foram negativamente afetados. O uso conjunto de B. bassiana e terra diatomácea, para o manejo de populações de A. diaperinus, pode reduzir o uso de produtos químicos
Bacterial insecticides and inert materials
[No abstract available
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