Interest representation in the EU: an open and structured dialogue?

Since 1992, the European Commission has sought to build ‘An Open and Structured Dialogue’ with interest groups, and since 2001 a broader ‘Dialogue with Civil Society’. A core feature of this dialogue involves instruments of transparency, and pluralism, with funding to ensure the presence of a wide range of voices. Consultation procedures provide for a ‘marketplace of ideas’ which simulate political competition and contestation, with a ‘voice but not a vote’, and which are supposed to provide for answerability by the European Commission for its policy choices. The European Commission also selects its allies to support its regulatory proposals, with NGOs frequent allies as well as firms and business sectors supporting higher standards. The EU’s fragmented decision-making system helps to provide a naturally pluralist environment, although some recent research suggests that NGOs are more likely to be successful in securing their policy goals than business organizations. NGOs work mostly in coalitions, with the size of coalition a factor in lobbying success. The saliency of issues is another substantial feature of variation in lobbying success and where NGOs can raise the contention of issues they can bring wider participation in EU issues

Signature of multilayer growth of 2D layered Bi2Se3 through heteroatom-assisted step-edge barrier reduction

During growth of two-dimensional (2D) materials, abrupt growth of multilayers is practically unavoidable even in the case of well-controlled growth. In epitaxial growth of a quintuple-layered Bi2Se3 film, we observe that the multilayer growth pattern deduced from in situ x-ray diffraction implies nontrivial interlayer diffusion process. Here we find that an intriguing diffusion process occurs at step edges where a slowly downward-diffusing Se adatom having a high step-edge barrier interacts with a Bi adatom pre-existing at step edges. The Se???Bi interaction lowers the high step-edge barrier of Se adatoms. This drastic reduction of the overall step-edge barrier and hence increased interlayer diffusion modifies the overall growth significantly. Thus, a step-edge barrier reduction mechanism assisted by hetero adatom???adatom interaction could be fairly general in multilayer growth of 2D heteroatomic materials

The desmosome and pemphigus

Desmosomes are patch-like intercellular adhering junctions (“maculae adherentes”), which, in concert with the related adherens junctions, provide the mechanical strength to intercellular adhesion. Therefore, it is not surprising that desmosomes are abundant in tissues subjected to significant mechanical stress such as stratified epithelia and myocardium. Desmosomal adhesion is based on the Ca2+-dependent, homo- and heterophilic transinteraction of cadherin-type adhesion molecules. Desmosomal cadherins are anchored to the intermediate filament cytoskeleton by adaptor proteins of the armadillo and plakin families. Desmosomes are dynamic structures subjected to regulation and are therefore targets of signalling pathways, which control their molecular composition and adhesive properties. Moreover, evidence is emerging that desmosomal components themselves take part in outside-in signalling under physiologic and pathologic conditions. Disturbed desmosomal adhesion contributes to the pathogenesis of a number of diseases such as pemphigus, which is caused by autoantibodies against desmosomal cadherins. Beside pemphigus, desmosome-associated diseases are caused by other mechanisms such as genetic defects or bacterial toxins. Because most of these diseases affect the skin, desmosomes are interesting not only for cell biologists who are inspired by their complex structure and molecular composition, but also for clinical physicians who are confronted with patients suffering from severe blistering skin diseases such as pemphigus. To develop disease-specific therapeutic approaches, more insights into the molecular composition and regulation of desmosomes are required

Real time monitoring of pentacene growth on Si O2 from a supersonic source

Thin film growth of pentacene on SiO2 using a supersonic source has been investigated with in situ real time synchrotron x-ray scattering and ex situ atomic force microscopy, focusing on the effects of incident kinetic energy Ei and growth rate GR on the evolution of surface roughness and the crystalline structure of the thin films. For the conditions examined here, Ei =2.5-7.2 eV and GR=0.0015-0.2 ML s-1, the thin film phase is always observed. We find that while the effect of Ei on interlayer transport is minimal, at high growth rates, slightly smoother films are observed. © 2008 American Institute of Physics

Coverage dependent adsorption dynamics in hyperthermal organic thin film growth

We have examined the dynamics of adsorption of diindenoperylene (DIP) on SiO2 and SiO2 modified with an interfacial organic layer using in situ real time synchrotron x-ray scattering, focusing on the effects of coverage. On both surfaces we observe a substantial increase in the probability of adsorption with increasing coverage, which is most dramatic at the highest incident kinetic energies. On the initially uncovered surfaces, we observe a smooth decrease in the probability of adsorption with increasing incident kinetic energy, indicative of trapping-mediated adsorption. Once both surfaces are covered by DIP, the effects of incident kinetic energy are greatly reduced, and trapping is very efficient over the range of kinetic energies examined. Possible reasons for efficient trapping at high coverage and at high incident kinetic energy include more efficient momentum transfer due to mass matching, and possibly direct molecular insertion. Comparison to results on another small-molecule, pentacene, suggests that this behavior should be common to hyperthermal growth of a variety of other small-molecule thin films

Post-deposition reorganization of pentacene films deposited on low-energy surfaces

We demonstrate that small-molecule organic thin films of pentacene deposited from thermal and supersonic molecular beam sources can undergo significant reorganization under vacuum or in N 2 atmosphere, beginning immediately after deposition of thin films onto SiO 2 gate dielectric treated with hexamethyldisilazane (HMDS) and fluorinated octyltrichlorosilane (FOTS). Films deposited on bare SiO 2 remain unchanged even after extended aging in vacuum. The changes observed on low-energy surfaces include the depletion of molecules in the interfacial monolayer resulting in the population of upper layers via upward interlayer transport of molecules, indicating a dewetting-like behavior. The morphology of pristine, as-deposited thin films was determined during growth by in situ real-time synchrotron X-ray reflectivity and was measured again, ex situ, by atomic force microscopy (AFM) following aging at room temperature in vacuum, in N 2 atmosphere, and in ambient air. Important morphological changes are observed in ultra-thin films (coverage < 5 ML) kept in vacuum or in N 2 atmosphere, but not in ambient air. AFM measurements conducted for a series of time intervals reveal that the rate of dewetting increases with decreasing surface energy of the gate dielectric. Films thicker than ∼5 ML remain stable under all conditions; this is attributed to the fact that the interfacial layer is buried completely for films thicker than ∼5 ML. This work highlights the propensity of small-molecule thin films to undergo significant molecular-scale reorganization at room temperature when kept in vacuum or in N 2 atmosphere after the end of deposition; it should serve as a cautionary note to anyone investigating the behavior of organic electronic devices and its relationship with the initial growth of ultra-thin molecular films on low-energy surfaces. © 2009 The Royal Society of Chemistry

Perfil pragmático de crianças surdas em diferentes fases lingüísticas Deaf children's pragmatic profile in different linguistic phases

OBJETIVO: O objetivo deste estudo foi verificar a interferência da fase lingüística no perfil comunicativo de crianças surdas. MÉTODOS: Trinta crianças surdas participaram deste estudo, sendo 15 crianças em fase pré-lingüística e 15 em fase lingüística (independente da modalidade comunicativa - língua oral ou língua de sinais), na faixa etária de 41 a 59 meses. Foram analisadas 30 gravações das habilidades comunicativas da criança, em situação de interação com a examinadora. Foi utilizado o Protocolo do Perfil Pragmático das Habilidades Iniciais da Comunicação para identificar quais as habilidades comunicativas ocorridas e qual a sua freqüência de ocorrência. RESULTADOS: Os dois grupos apresentaram basicamente as mesmas habilidades comunicativas; entretanto, o grupo Lingüístico apresentou maior freqüência de ocorr��ncia, principalmente nas habilidades relativas a intenções comunicativas e respostas para comunicação. CONCLUSÕES: Há relação direta entre a complexidade lingüística (independente da modalidade) e o perfil comunicativo da criança surda, ou seja, a criança em fase lingüística apresenta maior freqüência de ocorrência no uso das habilidades comunicativas mais complexas e elaboradas.<br>PURPOSE: The aim of this study was to ascertain and to assess the interference of deaf children's linguistic level in their communicative abilities. METHODS:Thirty deaf children participated in this study, 15 in the pre-linguistic phase and 15 in the linguistic phase, independent of the communicative modality used - either oral or sign language. Their age ranged from 41 to 59 months. Thirty videotape recordings of the deaf children's communicative abilities assessment during their interaction with the examiner were analyzed. The Communicative Abilities Pragmatic Profile was used in order to identify the communicative abilities and their frequency of occurrence. RESULTS: Both groups basically presented the same communicative abilities; however, the linguistic group presented higher frequency of occurrence, especially in the abilities regarding communicative intentions and responses for communication. CONCLUSIONS:There is a direct relationship between linguistic complexity (independent of any kind of modality) and the deaf child's communicative profile, that is, the linguistic level child presents higher frequency of occurrence of more complex and elaborated communicative abilities