7 research outputs found
MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFβ2
Get PDFMUC4 is highly expressed in human pancreatic tumours and pancreatic tumour cell lines, but is minimally or not expressed in normal pancreas or chronic pancreatitis. Here, we investigated the aberrant regulation of MUC4 expression in vivo using clonal human pancreatic tumour cells (CD18/HPAF) grown either orthotopically in the pancreas (OT) or ectopically in subcutaneous tissue (SC) in the nude mice. Histological examination of the OT and SC tumours showed moderately differentiated and anaplastic morphology, respectively. The OT tumour cells showed metastases to distant lymph nodes and faster tumour growth (
Microenvironment Effects on Promoting Upregulation of Matrix Metalloproteinases in Bcl-2-Overexpressing Renal Cell Carcinoma as a Response to Doxorubicin Treatment Inducing the Production of Metastasis
No full textQuantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent
No full textHealth Information Technologies—Academic and Commercial Evaluation (HIT-ACE) methodology: description and application to clinical feedback systems
No full text
