Space-time laser instabilities in homogeneously broadened dense media

We investigate the space-time dynamics of a homogeneously broadened single-mode laser when local field correction (LFC) is taken into account. We demonstrate that the Maxwell-Bloch equations modified by LFC admit travelling-wave solutions, as when LFC is not taken into account. Their stability is discussed and compared to the case without LFC

Stabilization of space–time laser instability through the finite transverse extension of pumping

We investigate the space–time dynamics of a homogeneously broadened single-mode laser when diffraction is taken into account. It is well known that such a laser displays instability when pumping reaches the second laser threshold. We show that the laser dynamics can be stabilized by pumping in a domain of finite width. The analysis of stationary solutions to the Maxwell–Bloch equations (evanescent waves, travelling waves, localized solutions) allows the stabilization mechanism to be explained

Analyse de dynamiques spatio-temporelles d’un laser

La dynamique spatio-temporelle d’un système laser avec diffraction est étudiée. La correspondance entre la structure du portrait de phase et l’organisation relative desdéfauts topologiques dans les diagrammes spatio-temporels est clairement mise en évidence. Ainsi, une dynamique de type chaos toroïdal est associée à des défauts apparaissant périodiquement (dans l’espace et dans le temps). En revanche, il n’y a plus de périodicité des défauts sur les diagrammes spatio-temporels lorsque le régime est un chaos développé

Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection

Introduction: Dengue virus infection is a global health problem lacking specific therapy, requiring an improved understanding of DENV immunity and vaccine responses. Considering the recent emerging of new dengue vaccines, here we performed an integrative systems vaccinology characterization of molecular signatures triggered by the natural DENV infection (NDI) and attenuated dengue virus infection models (DVTs). Methods and results: We analyzed 955 samples of transcriptomic datasets of patients with NDI and attenuated dengue virus infection trials (DVT1, DVT2, and DVT3) using a systems vaccinology approach. Differential expression analysis identified 237 common differentially expressed genes (DEGs) between DVTs and NDI. Among them, 28 and 60 DEGs were up or downregulated by dengue vaccination during DVT2 and DVT3, respectively, with 20 DEGs intersecting across all three DVTs. Enriched biological processes of these genes included type I/II interferon signaling, cytokine regulation, apoptosis, and T-cell differentiation. Principal component analysis based on 20 common DEGs (overlapping between DVTs and our NDI validation dataset) distinguished dengue patients by disease severity, particularly in the late acute phase. Machine learning analysis ranked the ten most critical predictors of disease severity in NDI, crucial for the anti-viral immune response. Conclusion: This work provides insights into the NDI and vaccine-induced overlapping immune response and suggests molecular markers (e.g., IFIT5, ISG15, and HERC5) for anti-dengue-specific therapies and effective vaccination development

Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder

Autism spectrum disorder (ASD) refers to a broad spectrum of neurodevelopmental disorders characterized by three central behavioral symptoms: impaired social interaction, impaired social communication, and restricted and repetitive behaviors. However, the symptoms are heterogeneous among patients and a number of ASD mouse models have been generated containing mutations that mimic the mutations found in human patients with ASD. Each mouse model was found to display a unique set of repetitive behaviors. In this review, we summarize the repetitive behaviors of the ASD mouse models and variations found in their neural mechanisms including molecular and electrophysiological features. We also propose potential neuronal mechanisms underlying these repetitive behaviors, focusing on the role of the cortico-basal ganglia-thalamic circuits and brain regions associated with both social and repetitive behaviors. Further understanding of molecular and circuitry mechanisms of the repetitive behaviors associated with ASD is necessary to aid the development of effective treatments for these disorders

Un modèle de composition des services web sémantiques

The work presented here aims to provide a composition model of semantic web services. This model is based on a semantic representation of domain concepts handled by web services, namely, operations and the static concepts used to describe static properties of Web services. Different levels of abstraction are given to the concept of operation to allow gradual access to concret services. Thus, two different levels of the composition plan are generated (abstract and concret). This will reuse plans already constructed to meet similar needs even with modified preferences.Le travail présenté ici vise à proposer un modèle pour la composition des services web sémantiques. Ce modèle est basé sur une représentation sémantique de l'ensemble des concepts manipulés par les services web d’un domaine d'application, à savoir, les opérations et les concepts statiques utilisés pour décrire les propriétés des services web. Différents niveaux d'abstraction sont donnés au concept opération pour permettre un accès progressif aux services concrets. Ainsi, deux plans de composition à granularités différentes (abstrait et concrets) sont générés. Ceci permettrade réutiliser des plans déjà construits pour répondre à des besoins similaires et même avec despréférences modifiées

Un modèle de composition des services web sémantiques

International audienceThe work presented here aims to provide a composition model of semantic web services. This model is based on a semantic representation of domain concepts handled by web services, namely, operations and the static concepts used to describe static properties of Web services. Different levels of abstraction are given to the concept of operation to allow gradual access to concret services. Thus, two different levels of the composition plan are generated (abstract and concret). This will reuse plans already constructed to meet similar needs even with modified preferences.Le travail présenté ici vise à proposer un modèle pour la composition des services web sémantiques. Ce modèle est basé sur une représentation sémantique de l'ensemble des concepts manipulés par les services web d’un domaine d'application, à savoir, les opérations et les concepts statiques utilisés pour décrire les propriétés des services web. Différents niveaux d'abstraction sont donnés au concept opération pour permettre un accès progressif aux services concrets. Ainsi, deux plans de composition à granularités différentes (abstrait et concrets) sont générés. Ceci permettrade réutiliser des plans déjà construits pour répondre à des besoins similaires et même avec despréférences modifiées

A Java-Web-Based-Learning Methodology, Case Study : Waterborne diseases

A Java-Web-Based-Learning Methodology, Case Study : Waterborne diseases The recent advances in web technologies have opened new opportunities for computer-based-education. One can learn independently of time and place constraints, and have instantaneous access to relevant updated material at minimal cost. Several web-based-learning systems have been developed. But, they stay limited : they cannot control and guide the learner due to the lack of interactivity of the web. This article proposes a java-based-methodology for web-based-learning systems that transcends these limits. This methodology supports student understanding by providing appropriate and immediate feedback, and a high level of interactivity. Key Words:Computer-based-education/ Web-based-learning/ Interactivity/ Individualized learning java/ Applet. Une Méthodologie d `enseignement basée-Java : Etude de cas les maladies à transmission hydrique Les développements récents des technologies Web ont fait émerger de nouvelles approches pour l'enseignement assisté par ordinateur. En effet, l'apprenant peut apprendre indépendamment des contraintes de temps et de lieu. Plusieurs systèmes basés sur le Web ont été développés. Cependant, ils demeurent limités : ils ne peuvent pas contrôler et guider l'apprenant vu le manque d'interactivité du Web. Dans cet article, nous présentons une approche basée sur Java pour la conception de systèmes d'enseignement qui surmontent les limites des systèmes existants. Cette approche offre un apprentissage à distance, invidualisé tenant compte du rythme de l'apprenant et supportant ainsi un haut niveau d'interactivité. Une étude de cas est présentée concernant les maladies à transmission hydrique. Mots-clés : Enseignement assisté par ordinateur/ Enseignement à distance/ Java/ Apprentissage invidualisé. Revue d'Information Scientifique & Technique Vol.11(2) 2001: 11-1

Fabrication and Characterization of Boron-Implanted Silicon Superconducting Thin Films on SOI Substrates for Low-Temperature Detectors

International audienc