Joint EANM, SNMMI and IAEA enabling guide: How to set up a theranostics centre

The theranostics concept using the same target for both imaging and therapy dates back to the middle of the last century, when radioactive iodine was first used to treat thyroid diseases. Since then, radioiodine has become broadly established clinically for diagnostic imaging and therapy of benign and malignant thyroid disease, worldwide. However, only since the approval of SSTR2-targeting theranostics following the NETTER-1 trial in neuroendocrine tumours and the positive outcome of the VISION trial has theranostics gained substantial attention beyond nuclear medicine. The roll-out of radioligand therapy for treating a high-incidence tumour such as prostate cancer requires the expansion of existing and the establishment of new theranostics centres. Despite wide global variation in the regulatory, financial and medical landscapes, this guide attempts to provide valuable information to enable interested stakeholders to safely initiate and operate theranostics centres. This enabling guide does not intend to answer all possible questions, but rather to serve as an overarching framework for multiple, more detailed future initiatives. It recognizes that there are regional differences in the specifics of regulation of radiation safety, but common elements of best practice valid globally

The Elasticity of Trust: How to Promote Trust in the Arab Middle East and the United States

To trust is to risk. When we lend someone money, we make ourselves vulnerable, hoping or expecting that the borrower will reward our trust and return the money at a later stage, possibly with interest or a reciprocal favor added. This paper examines whether willingness to trust follows the same logic, that is, whether it responds to changes in the expected value of trusting, much like willingness to take risk responds to changes in the expected value of risk taking in various countries of the Arab Middle East, namely, Jordan, Saudi Arabia and the United Arab Emirates and in the United States

Modular polyoxometalate-layered double hydroxides as efficient heterogeneous sulfoxidation and epoxidation catalysts

Selective sulfoxidation of sulfides and epoxidation of olefins are two types of important organic reactions and the corresponding products of sulfoxides, sulfones and epoxides are widely used as raw materials in industrial processes. The fabrication of one efficient catalyst for both reactions, remains a challenging task. In this paper, we report the preparation of a highly efficient heterogeneous catalyst of Mg3Al-ILs-La(PW11)2 using an exfoliation/assembly approach. The catalyst was characterized by FT-IR, XRD, TG/DTA, BET, XPS, 29Si CP/MAS NMR, the 27Al-MAS NMR, SEM, HRTEM, EDX etc. The designed catalyst showed high efficiency and selectivity for sulfoxidation of sulphides and epoxidation of olefins under mild conditions at a production rate of 208 mmol g-1 h-1 and 31 mmol g-1 h-1, respectively. Moreover, the Mg3Al-ILs-La(PW11)2 can be recycled and reused at least 5 times without obvious decrease of its catalytic activity. The scaled-up experiments revealed that the catalyst retained its efficiency and robustness, demonstrating the catalyts' great potential for industrial applications

Complex Learning in Multimedia Environments - Which Kind of Learning and How to do Research on it?

Based on an extensive analysis of a course in process automation engineering we explore the current state of research on complex learning by means of a request analysis. The analysis compared the type of research on complex learning which is needed with the actual state of the art of learning and the current relevant approaches we find today. Research on complex learning has to answer at least three questions: (1) What is a useful definition of learning? (2) What changes - how to describe what is learnt? (3) How does it change - how to describe the process of learning? We try to answer these three questions by seven theses, which describe important features of future research on complex learning

Behavior of a Model Dynamical System with Applications to Weak Turbulence

We experimentally explore solutions to a model Hamiltonian dynamical system derived in Colliander et al., 2012, to study frequency cascades in the cubic defocusing nonlinear Schr\"odinger equation on the torus. Our results include a statistical analysis of the evolution of data with localized amplitudes and random phases, which supports the conjecture that energy cascades are a generic phenomenon. We also identify stationary solutions, periodic solutions in an associated problem and find experimental evidence of hyperbolic behavior. Many of our results rely upon reframing the dynamical system using a hydrodynamic formulation.Comment: 22 pages, 14 figure

Unconstrained Face Detection and Open-Set Face Recognition Challenge

Face detection and recognition benchmarks have shifted toward more difficult environments. The challenge presented in this paper addresses the next step in the direction of automatic detection and identification of people from outdoor surveillance cameras. While face detection has shown remarkable success in images collected from the web, surveillance cameras include more diverse occlusions, poses, weather conditions and image blur. Although face verification or closed-set face identification have surpassed human capabilities on some datasets, open-set identification is much more complex as it needs to reject both unknown identities and false accepts from the face detector. We show that unconstrained face detection can approach high detection rates albeit with moderate false accept rates. By contrast, open-set face recognition is currently weak and requires much more attention.Comment: This is an ERRATA version of the paper originally presented at the International Joint Conference on Biometrics. Due to a bug in our evaluation code, the results of the participants changed. The final conclusion, however, is still the sam

Evaluation of the clinical safety and performance of a narrow diameter (2.9 mm) bone-level implant : a 1-year prospective single-arm multicenter study

Purpose Narrow-diameter implants facilitate single‐tooth restoration when interdental or inter-implant spaces and bone volume are inadequate for using standard diameter implants. This study reports the short-term data on the clinical safety and performance of a bone-level-tapered two-piece implant with a 2.9 mm diameter in the clinical practice setting. This study was retrospectively registered on March 1st, 2016 (NCT02699866). Methods Implants were placed in partially healed extraction sockets of the central and lateral incisors in the mandible and lateral incisors in the maxilla for single-tooth replacement. The primary outcome was to assess implant survival at 12 months after placement. Secondary outcomes included implant success, pink esthetic score, marginal bone-level changes, and safety. Results Twenty four males and 17 females with a mean age of 44.5 (± 18.3 standard deviation) received the implant. Three out of 41 implants were lost yielding a survival rate of 92.7% (95%-CI: 79.0%; 97.6%) at 1 year. One patient reported an ongoing foreign body sensation, pain, and/or dysesthesia at month 12. The average pink esthetic score at 6 months was 11.2 (95%-CI: 10.5; 11.9). The bone level was stable with a mean bone-level change of—0.3 mm (± 0.42 mm standard deviation) at 1 year after implantation. No serious adverse events or adverse device events were reported. Conclusions The use of a 2.9 mm diameter bone-level-tapered implant is a safe and reliable treatment option for narrow tooth gaps at the indicated locations. Overall performance and good survival rates support their use in cases, where wider implants are unsuitable

Mediterranean Sea response to climate change in an ensemble of twenty first century scenarios

The Mediterranean climate is expected to become warmer and drier during the twenty-first century. Mediterranean Sea response to climate change could be modulated by the choice of the socio-economic scenario as well as the choice of the boundary conditions mainly the Atlantic hydrography, the river runoff and the atmospheric fluxes. To assess and quantify the sensitivity of the Mediterranean Sea to the twenty-first century climate change, a set of numerical experiments was carried out with the regional ocean model NEMOMED8 set up for the Mediterranean Sea. The model is forced by air–sea fluxes derived from the regional climate model ARPEGE-Climate at a 50-km horizontal resolution. Historical simulations representing the climate of the period 1961–2000 were run to obtain a reference state. From this baseline, various sensitivity experiments were performed for the period 2001–2099, following different socio-economic scenarios based on the Special Report on Emissions Scenarios. For the A2 scenario, the main three boundary forcings (river runoff, near-Atlantic water hydrography and air–sea fluxes) were changed one by one to better identify the role of each forcing in the way the ocean responds to climate change. In two additional simulations (A1B, B1), the scenario is changed, allowing to quantify the socio-economic uncertainty. Our 6-member scenario simulations display a warming and saltening of the Mediterranean. For the 2070–2099 period compared to 1961–1990, the sea surface temperature anomalies range from +1.73 to +2.97 °C and the SSS anomalies spread from +0.48 to +0.89. In most of the cases, we found that the future Mediterranean thermohaline circulation (MTHC) tends to reach a situation similar to the eastern Mediterranean Transient. However, this response is varying depending on the chosen boundary conditions and socio-economic scenarios. Our numerical experiments suggest that the choice of the near-Atlantic surface water evolution, which is very uncertain in General Circulation Models, has the largest impact on the evolution of the Mediterranean water masses, followed by the choice of the socio-economic scenario. The choice of river runoff and atmospheric forcing both have a smaller impact. The state of the MTHC during the historical period is found to have a large influence on the transfer of surface anomalies toward depth. Besides, subsurface currents are substantially modified in the Ionian Sea and the Balearic region. Finally, the response of thermosteric sea level ranges from +34 to +49 cm (2070–2099 vs. 1961–1990), mainly depending on the Atlantic forcing

Comparison between open and closed methods of herniorrhaphy in calves affected with umbilical hernia

Umbilical hernias in calves commonly present to veterinary clinics, which are normally secondary to failure of the normal closure of the umbilical ring, and which result in the protrusion of abdominal contents into the overlying subcutis. The aim of this study was to compare the suitability of commonly-used herniorrhaphies for the treatment of reducible umbilical hernia in calves. Thirty-four clinical cases presenting to the Veterinary Teaching Hospital, Chittagong Veterinary and Animal Sciences University, Chittagong, Bangladesh from July 2004 to July 2007 were subjected to comprehensive study including history, classification of hernias, size of the hernial rings, presence of adhesion with the hernial sacs, postoperative care and follow-up. They were reducible, non-painful and had no evidence of infection present on palpation. The results revealed a gender influence, with the incidence of umbilical hernia being higher in female calves than in males. Out of the 34 clinical cases, 14 were treated by open method of herniorrhaphy and 20 were treated by closed method. Complications of hernia were higher (21%) in open method-treated cases than in closed method-treated cases (5%). Hernia recurred in three calves treated with open herniorrhaphy within 2 weeks of the procedure, with swelling in situ and muscular weakness at the site of operation. Shorter operation time and excellent healing rate (80%) were found in calves treated with closed herniorrhaphy. These findings suggest that the closed herniorrhaphy is better than the commonly-used open method for the correction of reducible umbilical hernia in calves