Management of multi-method engineering design research: a case study

There is a need for a research management methodology that will utilise research methods on an individual basis and when combined in a multi-method approach. An agreed methodology would enable rapid progress in achieving agreement on the main issues within engineering design research. Researchers at the University of Glasgow have developed a conceptual management methodology, testing it on three engineering design research projects. This paper describes the methodology and presents results indicating its ability to enable rigorous triangulation of research results obtained via different methods and across different research projects forming the basis of an effective management tool

Mother, I Didn\u27t Understand: Ballad

https://digitalcommons.library.umaine.edu/mmb-vp/2145/thumbnail.jp

An evaluation on the effectiveness of Web 2.0 Startpages (Netvibes & Pageflakes) within NHS libraries.

Carol McCormick was Learning Resources Advisor in the library at James Cook University Hospital, South Teesside when she completed her BSc (Hons) Librarianship (Work Based Learning) degree at Northumbria University. She gained a 1st Class Honours and is now Learning Resources Librarian. Carol’s dissertation formed part of a wider action research project into the provision of current awareness services at James Cook University Hospital. This article reports on the evaluation which was conducted after a Web 2.0 Startpage, or portal, had been introduced to improve access to current awareness information for all staff within the Trust. It is the second article in the Dissertations into practice series to examine the use of web-based tools to improve access to information for NHS staff

HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1

An estimated 10–20 million people worldwide are infected with human T cell leukemia virus type 1 (HTLV-1), with endemic areas of infection in Japan, Australia, the Caribbean, and Africa. HTLV-1 is the causative agent of adult T cell leukemia (ATL) and HTLV-1 associated myopathy/tropic spastic paraparesis (HAM/TSP). HTLV-1 expresses several regulatory and accessory genes that function at different stages of the virus life cycle. The regulatory gene Tax-1 is required for efficient virus replication, as it drives transcription of viral gene products, and has also been demonstrated to play a key role in the pathogenesis of the virus. Several studies have identified a PDZ binding motif (PBM) at the carboxyl terminus of Tax-1 and demonstrated the importance of this domain for HTLV-1 induced cellular transformation. Using a mass spectrometry-based proteomics approach we identified sorting nexin 27 (SNX27) as a novel interacting partner of Tax-1. Further, we demonstrated that their interaction is mediated by the Tax-1 PBM and SNX27 PDZ domains. SNX27 has been shown to promote the plasma membrane localization of glucose transport 1 (GLUT1), one of the receptor molecules of the HTLV-1 virus, and the receptor molecule required for HTLV-1 fusion and entry. We postulated that Tax-1 alters GLUT1 localization via its interaction with SNX27. We demonstrate that over expression of Tax-1 in cells causes a reduction of GLUT1 on the plasma membrane. Furthermore, we show that knockdown of SNX27 results in increased virion release and decreased HTLV-1 infectivity. Collectively, we demonstrate the first known mechanism by which HTLV-1 regulates a receptor molecule post-infection.</div

Determining the WIMP mass using the complementarity between direct and indirect searches and the ILC

We study the possibility of identifying dark matter properties from XENON-like 100 kg experiments and the GLAST satellite mission. We show that whereas direct detection experiments will probe efficiently light WIMPs, given a positive detection (at the 10% level for $m_{\chi} \lesssim 50$ GeV), GLAST will be able to confirm and even increase the precision in the case of a NFW profile, for a WIMP-nucleon cross-section $\sigma_{\chi-p} \lesssim 10^{-8}$ pb. We also predict the rate of production of a WIMP in the next generation of colliders (ILC), and compare their sensitivity to the WIMP mass with the XENON and GLAST projects.Comment: 32 pages, new figures and a more detailed statistical analysis. Final version to appear in JCA

Lithium in strong magnetic fields

The electronic structure of the lithium atom in a strong magnetic field 0 <= gamma <= 10 is investigated. Our computational approach is a full configuration interaction method based on a set of anisotropic Gaussian orbitals that is nonlinearly optimized for each field strength. Accurate results for the total energies and one-electron ionization energies for the ground and several excited states for each of the symmetries ^20^+, ^2(-1)^+, ^4(-1)^+, ^4(-1)^-, ^2(-2)^+, ^4(-2)^+, $^4(-3)^{+}$ are presented. The behaviour of these energies as a function of the field strength is discussed and classified. Transition wave lengths for linear and circular polarized transitions are presented as well.Comment: 12 pages, 13 figures, accepted for publication in Phys. Rev.

On modelling network coded ARQ-based channels

Network coding (NC) has been an attractive research topic in recent years as a means of offering a throughput improvement, especially in multicast scenarios. The throughput gain is achieved by introducing an algebraic method for combining multiple input streams of packets which are addressing one output port at an intermediate node. We present a practical implementation of network coding in conjunction with error control schemes, namely the Stop-and-Wait (SW) and Selective Repeat (SR) protocols. We propose a modified NC scheme and apply it at an intermediate SW ARQ-based link to reduce ARQ control signals at each transmission. We further extend this work to investigate the usefulness of NC in the Butterfly multicast network which adopts the SR ARQ protocol as an error control scheme. We validate our throughput analysis using a relatively recent discrete-event simulator, SimEvents®. The results show that the proposed scheme offers a throughput advantage of at least 50% over traditional SW ARQ, and that this is particularly noticeable in the presence of high error rates. In the multicast network, however, simulation results show that when compared with the traditional scheme, NC-SR ARQ can achieve a throughput gain of between 2% and 96% in a low bandwidth channel and up to 19% in a high bandwidth channel with errors

My Mother\u27s Evening Prayer

https://digitalcommons.library.umaine.edu/mmb-vp/4425/thumbnail.jp