Impact of Strain on the Performance of Si Nanowires Transistors at the Scaling Limit: A 3D Monte Carlo/2D Poisson Schrodinger Simulation Study

In this work we investigate the correlation between channel strain and device performance in various n-type Si-NWTs. We establish a correlation between strain, gate length and cross-section dimension of the transistors. For the purpose of this paper we simulate Si NWTs with a <110> channel orientation, four different ellipsoidal channel cross-sections and five gate lengths: 4nm, 6nm, 8nm, 10nm and 12nm. We have also analyzed the impact of strain on drain-induced barrier lowering (DIBL) and the subthreshold slope (SS). All simulations are based on a quantum mechanical description of the mobile charge distribution in the channel obtained from a 2D solution of the Schrödinger equation in multiple cross sections along the current path, which is mandatory for nanowires with such ultra-scale dimensions. The current transport along the channel is simulated using 3D Monte Carlo (MC) and drift-diffusion (DD) approaches

Low Noise and High Photodetection Probability SPAD in 180 nm Standard CMOS Technology

A square shaped, low noise and high photo-response single photon avalanche diode suitable for circuit integration, implemented in a standard CMOS 180 nm high voltage technology, is presented. In this work, a p+ to shallow n-well junction was engineered with a very smooth electric field profile guard ring to attain a photo detection probability peak higher than 50% with a median dark count rate lower than 2 Hz/μm2 when operated at an excess bias of 4 V. The reported timing jitter full width at half maximum is below 300 ps for 640 nm laser pulses

Novel muon imaging techniques

Owing to the high penetrating power of high-energy cosmic ray muons, muon imaging techniques can be used to image large bulky objects, especially objects with heavy shielding. Muon imaging systems work just like CT scanners in the medical imaging field—that is, they can reveal information inside of a target. There are two forms of muon imaging techniques: muon absorption imaging and muon multiple scattering imaging. The former is based on the flux attenuation of muons, and the latter is based on the multiple scattering of muons in matter. The muon absorption imaging technique is capable of imaging very large objects such as volcanoes and large buildings, and also smaller objects like spent fuel casks; the muon multiple scattering imaging technique is best suited to inspect smaller objects such as nuclear waste containers. Muon imaging techniques can be applied in a broad variety of fields, i.e. from measuring the magma thickness of volcanoes to searching for secret cavities in pyramids, and from monitoring the borders of countries checking for special nuclear materials to monitoring the spent fuel casks for nuclear safeguards applications. In this paper, the principles of muon imaging are reviewed. Image reconstruction algorithms such as Filtered Back Projection and Maximum Likelihood Expectation Maximization are discussed. The capability of muon imaging techniques is demonstrated through a Geant4 simulation study for imaging a nuclear spent fuel cask

Wide area cyclic blackout mitigation by supply-demand matching of HVAC counterpart loads

Many countries around the world are challenged to meet the escalating demand for power often resulting in frequent blackouts. Domestic standby generation and associated running costs are prohibitive and novel strategies to provision measures that manage blackouts are becoming much sought after. Almost all installed standby generation is not fully utilized and certain amounts of surplus power can be identified. The paper presents a strategy that harnesses the aggregated standby superfluous power to fulfil essential demand in residential areas during cyclic blackouts covering wide areas. The solution has at its foundation, a multiagent distributed demand management system with a supply-demand matching capability. Environmental conditions are monitored periodically and power is distributed accordingly to each sub-district. Customers at sub-districts receive a share of power according to two different distribution criteria and although their immediate allocated power is not the same, their overall daily power ration is equal. Air conditioners are backed up with less power demanding counterparts and a group of options is adaptively clustered. Their usage rights are distributed among customers according to available superfluous power. The approach is evaluated through an extensive emulation framework and results show that the proposed system is capable of providing an acceptable Quality-of-Service (QoS) level during cyclic blackout periods

Change detection and assessment of fire-damaged concrete using terrestrial laser scanning

Fire is one of the serious potential hazards to most structures and damage assessment is the first and the most important job for structural safety evaluation of a structure subjected to fire. The extensive use of concrete as a structural material has neccessitated an investigation into more robust and cost-effective techniques for the assessment of fire-damaged concrete using terrestrial laser scanning. Although concrete is known to be a fire resistant structural material, it undergoes severe changes when exposed to elevated temperatures and this can affect the load bearing capacity of structural bearing elements in several ways. Apart from spalling, there can be a permanent loss of strength in the remaining material. In the aftermath of a fire on a structure, various workers get involved in a variety of response and recovery from disaster operations. Furthermore, following a catastrophic failure of a structure after a fire, rescue workers and emergency responders may be required to enter the fire-damaged structure which can be risky and so an assessment method which has the potential to improve safety was investigated. Within the field of structural and civil engineering, the methods employed in assessing fire-damaged concrete involve both field and laboratory investigations to determine the extent of fire damage in order to design appropriate and cost effective repairs or to decide whether to demolition the structure. Concrete structures show significant loss of strength when heated above 300ºC. This study aimed at investigating whether terrestrial laser scanning can be used to detect fire-damaged concrete using specimens heated up to 1000ºC as it is important to estimate the maximum temperature attained in a fire. The results obtained from the study clearly demonstrated the feasibility of using terrestrial laser scanning to detect fire-damaged concrete via modelling and analysis of laser returned intensity. Laser scanning has emerged as a complementary assessment method of fire-damaged concrete with a couple of advantages in that the whole concrete element can be scanned and an average intensity value over the area concerned can be determined which would represent the whole element overcoming the challenge of some traditional methods where cores are drilled in limited areas. Scanning is rapid with millions of points measured in a few seconds. Laser scanning of the fire-damaged structure can be done from a distance without having to enter the structure and this improves safety. Laser scanning is a non-destructive technique for detecting fire-damaged concrete

Comparative 1D Blue-Native electrophoresis analysis of Plasmodium falciparum and human proteins associated with cytoadherence.

BACKGROUND To understand more about changes to the molecular components that occur when host endothelium interacts with Plasmodium falciparum-infected erythrocytes, a combined technique of protein separation (1D Blue-Native electrophoresis) and mass spectrometry of infected erythrocytes with endothelial cells (EC) in a co-culture system has been used. METHODS Native proteins were extracted from co-cultures and identified by mass spectrometry. Proteomic data from different parasite strains, either adhesion proficient (to endothelial cells) or non-adherent, were analysed in parallel to reveal protein associations linked to cytoadherence. Informatic approaches were developed to facilitate this comparison. RESULTS Blue-Native gel separation and LC/MS/MS identification revealed major differences in samples produced from endothelial cell co-culture with adherent and non-adherent parasite strains. This approach enabled us to identify protein associations seen only with the adhesion proficient parasite strain. CONCLUSIONS The combination of proteomic and analytical approaches has identified differences between adherent and non-adherent parasite lines in co-culture with EC, providing potential candidates for complexes or associations formed during cytoadherence involved in cell structure, signalling and apoptosis

A non-destructive technique for health assessment of fire-damaged concrete elements using terrestrial laser scanning

Concrete structures are routinely monitored to detect changes in their characteristics in the field of engineering surveying and other disciplines such as structural and civil engineering. There is growing demand for the development of reliable Non-Destructive Testing (NDT) techniques for concrete structures in the assessment of the deteriorating condition of infrastructures or in an event of fire-damaged structures. In this paper, the feasibility of using Terrestrial Laser Scanning (TLS) technology for change detection and assessment of fire-damaged concrete has been investigated through measurements and analysis of laboratory size concrete specimens that underwent heating up to 1000°C. The TLS technique employed in detecting fire-damaged concrete involved modelling and analysis of the TLS intensity returns as well as RGB image analysis. The results obtained clearly demonstrate the feasibility of using TLS to detect fire-damaged concrete. Although the laser scanners used in the study have different wavelengths, the results obtained in both cases are promising for a detection technique of fire-damaged concrete structures

The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4

Spy1A is a cyclin-like protein required for progression through the G(1)/S phase of the cell cycle. Elevated Spy1A protein levels have been implicated in tumorigenesis and are attributed to overriding the DNA damage response and enhancing cell proliferation. Understanding how Spy1A is produced and degraded is essential in resolving how it contributes to normal and abnormal growth processes. Herein, we demonstrate that Spy1A is degraded in a cell cycle-dependent manner during mitosis via the ubiquitin-proteasome system. We have resolved the E3 ligase and essential phosphorylation sites mediating Spy1A degradation. Furthermore, we have determined that non-degradable forms of Spy1A do not trigger cell cycle arrest but, rather, contribute to uncontrolled cell growth. Further investigation into the regulation of Spy1A may reveal novel strategies for understanding the etiology and progression of specific growth disorders