A relevance-focused search application for personalised ranking model

The assumption that users’ profiles can be exploited by employing their implicit feedback for query expansion through a conceptual search to index documents has been proven in previous research. Several successful approaches leading to an improvement in the accuracy of personalised search results have been proposed. This paper extends existing approaches and combines the keyword-based and semantic-based features in order to provide further evidence of relevance-focused search application for Personalised Ranking Model (PRM). A description of the hybridisation of these approaches is provided and various issues arising in the context of computing the similarity between users’ profiles are discussed. As compared to any traditional search system, the superiority of our approach lies in pushing significantly relevant documents to the top of the ranked lists. The results were empirically confirmed through human subjects who conducted several real-life Web searches

Photosynthesis-controlled calcification in a hypersaline microbial mat

We investigated the hypothesis that sulfate reduction rather than oxygenic photosynthesis promotes calcification in a hypersaline microbial mat by increasing the ion concentration product: ICP 5 [Ca2+] X [CO32-]. Pore‐water 3 calcium concentration profiles directly measured with microsensors show that calcium concentration in the photic zone decreased in illuminated mats and increased slightly in dark mats. High pH values in the photic zone of illuminated mats resulted in higher carbonate concentrations (2.25 mmol L-1) than in dark mats (0.75 mmol L-1), although the dissolved inorganic carbon (DIC) pore‐water concentration in the former was much lower (5.9 mmol L-1) than in the latter (9.9 mmol L-1). The pH‐induced rise in carbonate concentration in the light was the main factor influencing the ICP, while changes in Ca-1 concentration played a subsidiary role. Sulfate reduction did not result in a net pH increase in these mats, as rates in the photic zone were comparable between illuminated and dark mats (4 and 5 nmol cm-2 h-1, respectively), and pH increased in illuminated mats but not in dark mats. Calcium carbonate precipitation in the photic zone of these hypersaline mats is primarily controlled by photosynthesisinduced pH and carbonate concentration increases. However, heterotrophic bacteria, including sulfate reducers, play an important complementary role in calcification because they maintain high concentrations of DIC in the mat pore water

Забезпечення якості медичної допомоги в умовах запровадження в Україні обов'язкового медичного страхування (адміністративно-правові принципи та складові елементи)

Аналізуються адміністративно правові принципи та складові елементи забезпечення якості медичної допомоги в умовах запровадження в Україні обов’язкового медичного страхування. Особлива увага приділена питанням контролю якості медичної допомоги. Ключові слова: якість надання медичної допомоги, обов’язкове медичне страхування.Анализируются административно правовые принципы и составляющие части обеспечения качества медицинской помощи в условиях утверждения в Украине обязательного медицинского страхования. Особое внимание уделено вопросам контроля качества оказания медицинской помощи. Ключевые слова: качество медицинской помощи, обязательное медицинское страхование.Administrative and legal principles and component parts of providing medical care quality in conditions of introducing compulsory medical insurance in Ukraine are analyzed in the article. Special attention is paid to the control provision of medical care quality. Key words: medical care quality, compulsory medical insurance

Hyperspectral imaging of the microscale distribution and dynamics of microphytobenthos in intertidal sediments

We describe a novel, field-deployable hyperspectral imaging system, called Hypersub, that allows noninvasive in situ mapping of the microphytobenthos (MPB) biomass distribution with a high spatial (sub-millimeter) and temporal (minutes) resolution over areas of 1 x 1 m. The biomass is derived from a log-transformed and near-infrared corrected reflectance hyperspectral index, which exhibits a linear relationship (R-2 > 0.97) with the chlorophyll a (Ch1 a) concentration in the euphotic zone of the sediment and depends on the sediment grain size. Deployments of the system revealed that due to factors such as sediment topography, bioturbation, and grazing, the distribution of MPB in intertidal sediments is remarkably heterogeneous, with Ch1 a concentrations varying laterally by up to 400% of the average value over a distance of 1 cm. Furthermore, due to tidal cycling and diel light variability, MPB concentrations in the top 1 mm of sediments are very dynamic, changing by 40-80% over a few hours due to vertical migration. We argue that the high-resolution hyperspectral imaging method overcomes the inadequate resolution of traditional methods based on sedimentary Ch1 a extraction, and thus helps improve our understanding of the processes that control benthic primary production in coastal sediments

Bimetallic Pt(II)-bipyridyl-diacetylide/Ln(III) tris-diketonate adducts based on a combination of coordinate bonding and hydrogen bonding between the metal fragments: syntheses, structures and photophysical properties

The luminescent Pt(II) complex [Pt(4,4'-Bu-t(2)-bipy){CC-(5-pyrimidinyl)}(2)] (1) was prepared by coupling of [Pt(4,4'-Bu-t(2)-bipy)Cl-2] with 5-ethynyl-pyrimidine, and contains two pyrimidinyl units pendant from a Pt(H) bipyridyl diacetylide core; it shows luminescence at 520 nm which is typical of Pt(II) luminophores of this type. Reaction with [Ln(hfac)(3)(H2O)(2)] (hfac = anion of hexafluoroacetylacetone) affords as crystalline solids the compounds [1 center dot {Ln(hfac)(3)(H2O)}{Ln(hfac)(3)(H2O)(2)}] (Ln = Nd, Gd, Er, Yb), in which the {Ln(hfac)(3)(H2O)} unit is coordinated to one pyrimidine ring via an N atom, whereas the {Ln(hfac)(3)(H2O)(2)} unit is associated with two N atoms, one from each pyrimidine ring of 1, via N center dot center dot center dot HOH hydrogen-bonding interactions involving the coordinated water ligands on the lanthanide centre. Solution spectroscopic studies show that the luminescence of 1 is partly quenched on addition of [Ln(hfac)(3)(H2O)(2)] (Ln = Er, Nd) by formation of Pt(II)/Ln(III) adducts in which Pt(II)-> Ln(III) photoinduced energy-transfer occurs to the low-lying f-f levels of the Ln(Ill) centre. Significant quenching occurs with both Er(Ill) and Nd(III) because both have several f-f states which match well the (MLCT)-M-3 emission energy of 1. Time-resolved luminescence studies show that Pt(II)-Er(III) energy-transfer (7.0 x 10(7) M-1) is around three times faster than Pt(II)-> Nd(III) energy-transfer (approximate to 2 x 10(7) M-1) over the same distance because the luminescence spectrum of l overlaps better with the absorption spectrum of Er(111) than with Nd(III). In contrast Yb(111) causes no significant quenching of 1 because it has only a single f-f excited level which is a poor energy match for the Pt(II)-based excited state

High Effective Coverage of Vector Control Interventions in Children After Achieving Low Malaria Transmission in Zanzibar, Tanzania.

\ud \ud Formerly a high malaria transmission area, Zanzibar is now targeting malaria elimination. A major challenge is to avoid resurgence of malaria, the success of which includes maintaining high effective coverage of vector control interventions such as bed nets and indoor residual spraying (IRS). In this study, caretakers' continued use of preventive measures for their children is evaluated, following a sharp reduction in malaria transmission. A cross-sectional community-based survey was conducted in June 2009 in North A and Micheweni districts in Zanzibar. Households were randomly selected using two-stage cluster sampling. Interviews were conducted with 560 caretakers of under-five-year old children, who were asked about perceptions on the malaria situation, vector control, household assets, and intention for continued use of vector control as malaria burden further decreases. Effective coverage of vector control interventions for under-five children remains high, although most caretakers (65%; 363/560) did not perceive malaria as presently being a major health issue. Seventy percent (447/643) of the under-five children slept under a long-lasting insecticidal net (LLIN) and 94% (607/643) were living in houses targeted with IRS. In total, 98% (628/643) of the children were covered by at least one of the vector control interventions. Seasonal bed-net use for children was reported by 25% (125/508) of caretakers of children who used bed nets. A high proportion of caretakers (95%; 500/524) stated that they intended to continue using preventive measures for their under-five children as malaria burden further reduces. Malaria risk perceptions and different perceptions of vector control were not found to be significantly associated with LLIN effective coverage While the majority of caretakers felt that malaria had been reduced in Zanzibar, effective coverage of vector control interventions remained high. Caretakers appreciated the interventions and recognized the value of sustaining their use. Thus, sustaining high effective coverage of vector control interventions, which is crucial for reaching malaria elimination in Zanzibar, can be achieved by maintaining effective delivery of these interventions

Quantitative analysis of powder mixtures by raman spectrometry : the influence of particle size and its correction

Particle size distribution and compactness have significant confounding effects on Raman signals of powder mixtures, which cannot be effectively modeled or corrected by traditional multivariate linear calibration methods such as partial least-squares (PLS), and therefore greatly deteriorate the predictive abilities of Raman calibration models for powder mixtures. The ability to obtain directly quantitative information from Raman signals of powder mixtures with varying particle size distribution and compactness is, therefore, of considerable interest In this study, an advanced quantitative Raman calibration model was developed to explicitly account for the confounding effects of particle size distribution and compactness on Raman signals of powder mixtures. Under the theoretical guidance of the proposed Raman calibration model, an advanced dual calibration strategy was adopted to separate the Raman contributions caused by the changes in mass fractions of the constituents in powder mixtures from those induced by the variations in the physical properties of samples, and hence achieve accurate quantitative determination for powder mixture samples. The proposed Raman calibration model was applied to the quantitative analysis of backscatter Raman measurements of a proof-of-concept model system of powder mixtures consisting of barium nitrate and potassium chromate. The average relative prediction error of prediction obtained by the proposed Raman calibration model was less than one-third of the corresponding value of the best performing PLS model for mass fractions of barium nitrate in powder mixtures with variations in particle size distribution, as well as compactness

Processing-Induced Disorder in Pharmaceutical Materials

This chapter focuses on the major types of pharmaceutical processing methods that have been widely reported to produce disordered material either intentionally or unintentionally. Milling is one of the most frequently used unit operations used by the pharmaceutical industry for reducing the particle size of solids. Thermal processing techniques are mainly used for controlling or improving the release and the subsequent bioavailability of an active pharmaceutical ingredient (API). Techniques such as melt-mixing, spray-congealing, sintering, melt-granulation, and hot-melt extrusion (HME) have developed and evolved rapidly for large-scale pharmaceutical production. Solvent-evaporation-based methods are important processing techniques for both raw materials, such as crystallization of the raw drug, and formulation manufacturing in the pharmaceutical industry. The chapter discusses the processing that can potentially induce the formation of the disordered state during the manufacture of formulations. The widely used solvent-evaporation-based processing techniques in pharmaceutical formulation production include spray-drying, freeze-drying, film casting, and film coating

GEPAS, a web-based tool for microarray data analysis and interpretation

Gene Expression Profile Analysis Suite (GEPAS) is one of the most complete and extensively used web-based packages for microarray data analysis. During its more than 5 years of activity it has continuously been updated to keep pace with the state-of-the-art in the changing microarray data analysis arena. GEPAS offers diverse analysis options that include well established as well as novel algorithms for normalization, gene selection, class prediction, clustering and functional profiling of the experiment. New options for time-course (or dose-response) experiments, microarray-based class prediction, new clustering methods and new tests for differential expression have been included. The new pipeliner module allows automating the execution of sequential analysis steps by means of a simple but powerful graphic interface. An extensive re-engineering of GEPAS has been carried out which includes the use of web services and Web 2.0 technology features, a new user interface with persistent sessions and a new extended database of gene identifiers. GEPAS is nowadays the most quoted web tool in its field and it is extensively used by researchers of many countries and its records indicate an average usage rate of 500 experiments per day. GEPAS, is available at http://www.gepas.org