A systematic approach to the formulation of anti-onychomycotic nail patches

Nail patches have a potential role as drug carriers for the topical treatment of nail diseases such as onychomycosis, a common condition. O ur aim was therefore to develop a systematic and novel appr oach to the formulat ion of a simple drug -in-adhesive ungual patch. Twelve pressure -sensitive adhesives (PSAs), four backing membranes, two release liners and three drugs were screened for pharmaceutical and mechanical properties . From this initial screeni ng, two PSAs, two drugs, one backing membrane and one release liner were selected for further investigation. Patches were prepared by solvent -casting and characterised. The patches had good uniformity of thickness and of drug content, and showed minimal drug crystallisation during six month s of storage. Meanwhile, the d rug stability in the patch upon storage and patch adhesion to the nail was influenced by the nature of the drug, the PSA and the backing membrane . The reported methodology paves the way for a systematic formulation of ungual nail patches to add to the armamentarium of nail medicines . Further , from this work, the best patch formulation has been identified

Modeling the effect of rate and geometry on peeling and tack of pressure-sensitive adhesives

A model is developed for predicting separation along interfaces of pressure sensitive adhesives. Many authors have used the cohesive zone approach to solve such problems but the parameter calibration of such models remains uncertain. This study reports a novel method for determining such parameters. In addition, it provides crucial evidence for the suitability of the cohesive zone model approach in modelling interface fractures. Peel tests were performed at various rates using specimens which consisted of a polyester backing membrane supporting an acrylic pressure-sensitive adhesive (PSA) adhered to a polyethylene substrate. Interfacial separation of the PSA from the polyethylene substrate was observed. Finite element (FE) peeling simulations were conducted which modeled the backing-membrane as an elasto-plastic power-law material, the adhesive as a viscoelastic material and the interfacial properties with a cohesive zone model (CZM). The material properties of the backing membrane and the pressure-sensitive adhesive were measured from tensile and stress relaxation experiments. The rate-dependent CZM parameters were measured directly from poker-chip probe-tack tests which were performed at pull-off speeds which corresponded to the rates employed for the peel tests. The effect of the PSA thickness and test rate on both tack and peel was investigated experimentally, as well as modeled numerically. Good agreement was found between the experimentally measured and numerically predicted peel forces for different peel angles, speeds and PSA thicknesses. In addition, it was proven that the rate dependence observed in the peel and probe-tack data was dominated by the rate dependence of the interface properties, i.e. the time dependence of the two CZM parameters of maximum stress and fracture energy, rather than the time-dependent bulk viscoelasticity of the PSA peel arm

Визнання арбітражної угоди недійсною

У статті розглянуто питання недійсності арбітражної угоди, визначені етапи, на яких виникає дане питання, досліджені підстави для визнання арбітражної угоди недійсною.В статье рассмотрен вопрос недействительности арбитражного соглашения, определены этапы, на которых возникает данный вопрос, исследованы основания для признания арбитражного соглашения недействительным.This article analyses the issue of invalidity of the arbitration agreement, marks out the stages on which this matter arises, examines the grounds for invalidity of the arbitration agreement

Purpura Fulminans with Disseminated Intravascular Coagulopathy and Symmetric Peripheral Gangrene Complicating Sepsis in an Infant: A Case Report

Purpura fulminans is a rare consequence of sepsis that could be complicated by DIC and gangrene. We report the case of a 2-months-old infant who developed gangrenous limbs. He presented with fever, diarrhoea, vomiting and irritability for 5 days and was dehydrated and unconscious with global hypertonia. With a clinical impression of sepsis antibiotics, IV fluids and supportive care were commenced. He developed purpuric rashes over the trunk and feet, the latter of which gradually ascended over the legs, with swellings and ischemic skin changes up to the knees. A diagnosis of purpura fulminans was made and further evaluation revealed deranged haematologic parameters, features of Disseminated Intravascular Coagulopathy (DIC), hypernatraemia, azotaemia and arterial occlusion. Despite blood transfusions and supportive care gangrene emerged and progressively ascended towards the knees. Parents however rejected offer for surgical amputation and left against medical advice. The coexistence of purpura fulminans with multiple triggers for DIC should alert clinicians of a potential risk of peripheral gangrene.Keywords: Infant, Sepsis, Purpura fulminans, DIC, Gangren

Utilizing community health workers as skilled birth attendants in rural communities in Nigeria

Objective: The Nigerian Midwives Service Scheme (MSS) was designed to address the scarcity of skilled birth attendants at primary health care levels. Although, Nigeria has a rich population of trained Midwives, theirdeployment and retention at communities in critical need for their skills remains a huge challenge. Community Health Workers (CHWs) are readily available and could bridge the gap of connecting the family, community and the referral facilities.Methods: A cross-sectional survey of CHWs to assess their knowledge and skills on various aspects of maternal and newborn health care using structured questionnaire and focused group discussions.Results: A total of 329 CHWs were studied. The mean duration of service provision related to Maternal Newborn and Child Health (MNCHs) of the participants was 8.9 years. Their general knowledge on Antenatal care (ANC) and basic midwifery was good, although majority had problems assessing gestational age using anatomical landmarks, identifying abnormal labour and diagnosing fetal distress in labor.Conclusion: CHWs can effectively fill in the gaps in poor access to skilled birth attendance in Nigeria if given the requisite training.Keywords: Skilled birth attendance, Community Health Workers, Maternal and New born Health, Nigeri

Tough nanoparticle-modified polymers

A crosslinked epoxy polymer has been modified by the addition of nano-silica particles. The particles were introduced via a sol-gel technique which gave a very well dispersed phase of nano-silica particles which were about 20 nm in diameter. The glass transition temperature was unchanged by the addition of the nanoparticles, but both the modulus and toughness were increased. The fracture energy, GIc, increased from 100 J/m 2 for the unmodified epoxy to 460 J/m2 for the epoxy with 20 wt. % of nano-silica. The microscopy studies showed evidence of debonding of the nanoparticles and subsequent plastic void growth of the epoxy polymer. A theoretical model of plastic void growth was used to confirm this mechanism. The cyclic-fatigue behaviour of the epoxy polymers has also been studied and the fatigue properties were clearly enhanced by the presence of the nano-silica particles. Indeed, it was found that the values of the strain-energy release rate at threshold, Gth, from the cyclic-fatigue tests increased steadily as the toughness, GIc, also increased, i.e. as the concentration of nano-silica particles was increased

Evaluating the ecological and social targeting of a compensation scheme in Bangladesh.

Conservation payments are increasingly advocated as a way to meet both social and ecological objectives, particularly in developing countries, but these payments often fail to reach the 'right' individuals. The Government of Bangladesh runs a food compensation scheme that aims to contribute to hilsa (Tenualosa ilisha) conservation by improving the socioeconomic situation of households affected by hilsa sanctuary fishing bans. Analysing data from a household survey of compensation recipients and non-recipients, we identify the current correlates of compensation distribution and explore perceptions of fairness in this distribution. We find that distribution is largely spatial rather than based on the household characteristics that are supposed to determine eligibility for compensation, indicating political influence in the distribution process. We also find the compensation scheme is widely perceived to be unfair, which could be undermining its potential to compensate vulnerable fishers while improving compliance with fishing bans. The spatial distribution of compensation would shift substantially under alternative targeting scenarios that are likely to improve the cost-effectiveness of the scheme, such as targeting those who are most dependent on fishing for their livelihood. This study highlights a challenge for conservation payment schemes that aim to achieve the dual objectives of poverty reduction and ecological sustainability, particularly large-scale public schemes, and suggests that more effective targeting and transparency about the basis of payment distribution are prerequisites for schemes to be both cost-effective and socially acceptable

A dual-loop tracking control approach to precise nanopositioning

The author(s) received no financial support for the research, authorship, and/or publication of this article.Peer reviewedPostprin

Перспективи розвитку експортоорієнтованої стратегії підприємств

Рассмотрен вопрос стратегического развития экспортноориентрованной политики предприятий. Раскрыты перспективы развития международных торговых отношений Украины.Розглянуто питання стратегічного розвитку експортноорієнтовної політики підприємств. Розкрито перспективи розвитку міжнародних торгівельних відносин України

Phylogeography of Japanese encephalitis virus:genotype is associated with climate

The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts. What is less clear are the factors influencing the distribution of virus-specific lineages. Japanese encephalitis virus (JEV) is the most important etiologic agent of epidemic encephalitis worldwide, and is primarily maintained between vertebrate reservoir hosts (avian and swine) and culicine mosquitoes. There are five genotypes of JEV: GI-V. In recent years, GI has displaced GIII as the dominant JEV genotype and GV has re-emerged after almost 60 years of undetected virus circulation. JEV is found throughout most of Asia, extending from maritime Siberia in the north to Australia in the south, and as far as Pakistan to the west and Saipan to the east. Transmission of JEV in temperate zones is epidemic with the majority of cases occurring in summer months, while transmission in tropical zones is endemic and occurs year-round at lower rates. To test the hypothesis that viruses circulating in these two geographical zones are genetically distinct, we applied Bayesian phylogeographic, categorical data analysis and phylogeny-trait association test techniques to the largest JEV dataset compiled to date, representing the envelope (E) gene of 487 isolates collected from 12 countries over 75 years. We demonstrated that GIII and the recently emerged GI-b are temperate genotypes likely maintained year-round in northern latitudes, while GI-a and GII are tropical genotypes likely maintained primarily through mosquito-avian and mosquito-swine transmission cycles. This study represents a new paradigm directly linking viral molecular evolution and climate