Growth Management Effectiveness: A Literature Review

Although growth management programs have many purposes, a critical one is to contain urban and suburban sprawl. Their efficacy in this regard is not well understood. In this paper, we review a comprehensive set of growth management tools, used by urban planners and policymakers to curb sprawl, starting with the history of the tool, then describing how it works in practice, and finally presenting any available empirical evidence on how well it works to curb sprawl and/or achieve other public purposes. While growth management isn't a panacea for controlling sprawl, it is certainly not the failure implied by critics

In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

<p>Abstract</p> <p>Background</p> <p>Recently, human T-cell leukemia virus type 1 (HTLV-1) basic leucine zipper factor (HBZ), encoded from a minus strand mRNA was discovered and was suggested to play an important role in adult T cell leukemia (ATL) development. However, there have been no reports on the role of HBZ in patients with HTLV-1 associated inflammatory diseases.</p> <p>Results</p> <p>We quantified the HBZ and tax mRNA expression levels in peripheral blood from 56 HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, 10 ATL patients, 38 healthy asymptomatic carriers (HCs) and 20 normal uninfected controls, as well as human leukemic T-cell lines and HTLV-1-infected T-cell lines, and the data were correlated with clinical parameters. The spliced HBZ gene was transcribed in all HTLV-1-infected individuals examined, whereas tax mRNA was not transcribed in significant numbers of subjects in the same groups. Although the amount of HBZ mRNA expression was highest in ATL, medium in HAM/TSP, and lowest in HCs, with statistical significance, neither tax nor the HBZ mRNA expression per HTLV-1-infected cell differed significantly between each clinical group. The HTLV-1 HBZ, but not tax mRNA load, positively correlated with disease severity and with neopterin concentration in the cerebrospinal fluid of HAM/TSP patients. Furthermore, HBZ mRNA expression per HTLV-1-infected cell was decreased after successful immunomodulatory treatment for HAM/TSP.</p> <p>Conclusion</p> <p>These findings suggest that <it>in vivo </it>expression of HBZ plays a role in HAM/TSP pathogenesis.</p

HTLV-1 Evades Type I Interferon Antiviral Signaling by Inducing the Suppressor of Cytokine Signaling 1 (SOCS1)

Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of Adult T cell Leukemia (ATL) and the neurological disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although the majority of HTLV-1–infected individuals remain asymptomatic carriers (AC) during their lifetime, 2–5% will develop either ATL or HAM/TSP, but never both. To better understand the gene expression changes in HTLV-1-associated diseases, we examined the mRNA profiles of CD4+ T cells isolated from 7 ATL, 12 HAM/TSP, 11 AC and 8 non-infected controls. Using genomic approaches followed by bioinformatic analysis, we identified gene expression pattern characteristic of HTLV-1 infected individuals and particular disease states. Of particular interest, the suppressor of cytokine signaling 1—SOCS1—was upregulated in HAM/TSP and AC patients but not in ATL. Moreover, SOCS1 was positively correlated with the expression of HTLV-1 mRNA in HAM/TSP patient samples. In primary PBMCs transfected with a HTLV-1 proviral clone and in HTLV-1-transformed MT-2 cells, HTLV-1 replication correlated with induction of SOCS1 and inhibition of IFN-α/β and IFN-stimulated gene expression. Targeting SOCS1 with siRNA restored type I IFN production and reduced HTLV-1 replication in MT-2 cells. Conversely, exogenous expression of SOCS1 resulted in enhanced HTLV-1 mRNA synthesis. In addition to inhibiting signaling downstream of the IFN receptor, SOCS1 inhibited IFN-β production by targeting IRF3 for ubiquitination and proteasomal degradation. These observations identify a novel SOCS1 driven mechanism of evasion of the type I IFN antiviral response against HTLV-1

Effects of Temperature Differences in Optimization of Spiral Plate Heat Exchangers

In this research, three aspects of modeling, analyzing, and optimizing spiral plate heat exchangers (SPHEs) are studied. The main objective of this work is to pave the way for comparing manufacturers’ designed SPHEs with theoretical designed SPHEs without involving designers in using computational methods. To begin, with assumption of constant overall heat transfer coefficient and specific heat capacities, a mathematical modeling of SPHE based on energy balance equations is developed to model the SPHE as a network of series-connected equivalent internal heat exchangers to determine the temperature distribution in spiral turns. This modeling can facilitate the usage of temperature-enthalpy diagram in SPHEs’ analysis and design. Furthermore, a new algorithm for thermal design optimization of SPHEs has been proposed. The proposed algorithm is based on maximizing pressure drops at channels, considering geometric proportion of SPHE and minimizing the total cost simultaneously. To show the proposed method applicability in analyzing thermal and hydraulic design parameters, a single-phase counter-current SPHE is assessed and optimized for different design cases with temperature approach variations. Results of comparing manufacturers’/standard designed SPHEs and research/theoretical designed SPHEs by defining appropriate geometric proportion ranges confirmed that temperature approach variations can improve SPHE performance to a higher extent, such as finding temperature approach ranges for optimized SPHEs with higher compactness to reduce the manufacturing cost. This fact is revealed by introducing compactness-temperature approach diagram which depicts the geometric optimization of SPHEs and the effects of temperature differences in SPHE’s optimization

Reducing Vehicle Miles Traveled, Encouraging Walk Trips, and Facilitating Efficient Trip Chains Through Polycentric Development

Compact development can result in many benefits for communities and residents. Areas can connect compact developments through high-quality transportation options, creating a network of centers, or a “polycentric” region. This development pattern is very popular in Europe and is linked to significant benefits. Salt Lake County has organically developed several small centers, and with the right strategies could continue to fuel this kind of growth. The metropolitan planning organization (MPO) for the region, the Wasatch Front Regional Council, has been planning for polycentric development since the Wasatch Choice for 2040 Vision was released in 2010. Our research is aimed at exploring the academic literature and empirical evidence surrounding polycentric development, analyzing more than 120 regional transportation plans (RTP) to see how they promote polycentric development, defining types of centers in a hierarchy of centers, quantifying the transportation benefits of polycentric development, examining a case study of best practices, and, finally, outlining context-specific strategies for Salt Lake County and the Wasatch Front. The resulting report will enable the county and MPO to make informed decisions about its future growth patterns, set realistic—yet visionary—goals, and improve the overall health of its residents and communities