Selective Deuterium Ion Acceleration Using the Vulcan PW Laser

We report on the successful demonstration of selective acceleration of deuterium ions by target-normal sheath acceleration (TNSA) with a high-energy petawatt laser. TNSA typically produces a multi-species ion beam that originates from the intrinsic hydrocarbon and water vapor contaminants on the target surface. Using the method first developed by Morrison, et al.,$^{1}$ an ion beam with $>$99$\%$ deuterium ions and peak energy 14 MeV/nucleon is produced with a 200 J, 700 fs, $>10^{20} W/cm^{2}$ laser pulse by cryogenically freezing heavy water (D$_{2}$O) vapor onto the rear surface of the target prior to the shot. Within the range of our detectors (0-8.5$^{\circ}$), we find laser-to-deuterium-ion energy conversion efficiency of 4.3$\%$ above 0.7 MeV/nucleon while a conservative estimate of the total beam gives a conversion efficiency of 9.4$\%$.Comment: 5 pages, 5 figure

2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry

Objectives: Specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population. Background: We sought to re-evaluate the frequency, manifestations, and severity of acute adverse reactions associated with administration of several gadolinium- based contrast agents during routine CMR on a European level. Methods: Multi-centre, multi-national, and multi-ethnical registry with consecutive enrolment of patients in 57 European centres. Results: During the current observation 37788 doses of Gadolinium based contrast agent were administered to 37788 patients. The mean dose was 24.7 ml (range 5–80 ml), which is equivalent to 0.123 mmol/kg (range 0.01 - 0.3 mmol/kg). Forty-five acute adverse reactions due to contrast administration occurred (0.12 %). Most reactions were classified as mild (43 of 45) according to the American College of Radiology definition. The most frequent complaints following contrast administration were rashes and hives (15 of 45), followed by nausea (10 of 45) and flushes (10 of 45). The event rate ranged from 0.05 % (linear non-ionic agent gadodiamide) to 0.42 % (linear ionic agent gadobenate dimeglumine). Interestingly, we also found different event rates between the three main indications for CMR ranging from 0.05 % (risk stratification in suspected CAD) to 0.22 % (viability in known CAD). Conclusions: The current data indicate that the results of the earlier safety data hold true in this much larger multi-national and multi-ethnical population. Thus, the “off-label” use of Gadolinium based contrast in cardiovascular MR should be regarded as safe concerning the frequency, manifestation and severity of acute events

Anomaly mediated SUSY breaking scenarios in the light of cosmology and in the dark (matter)

Anomaly mediation is a popular and well motivated supersymmetry breaking scenario. Different possible detailed realisations of this set-up are studied and actively searched for at colliders. Apart from limits coming from flavour, low energy physics and direct collider searches, these models are usually constrained by the requirement of reproducing the observations on dark matter density in the universe. We reanalyse these bounds and in particular we focus on the dark matter bounds both considering the standard cosmological model and alternative cosmological scenarios. These scenarios do not change the observable cosmology but relic dark matter density bounds strongly depend on them. We consider few benchmark points excluded by standard cosmology dark matter bounds and suggest that loosening the dark matter constraints is necessary in order to avoid a too strong (cosmological) model dependence in the limits that are obtained for these models. We also discuss briefly the implications for phenomenology and in particular at the Large Hadron Collider.Comment: 37 pages, 20 figures, 1 tabl

Charged-Higgs phenomenology in the Aligned two-Higgs-doublet model

The alignment in flavour space of the Yukawa matrices of a general two-Higgs-doublet model results in the absence of tree-level flavour-changing neutral currents. In addition to the usual fermion masses and mixings, the aligned Yukawa structure only contains three complex parameters, which are potential new sources of CP violation. For particular values of these three parameters all known specific implementations of the model based on discrete Z_2 symmetries are recovered. One of the most distinctive features of the two-Higgs-doublet model is the presence of a charged scalar. In this work, we discuss its main phenomenological consequences in flavour-changing processes at low energies and derive the corresponding constraints on the parameters of the aligned two-Higgs-doublet model.Comment: 46 pages, 19 figures. Version accepted for publication in JHEP. References added. Discussion slightly extended. Conclusions unchange

Direct CP violation in charm and flavor mixing beyond the SM

We analyze possible interpretations of the recent LHCb evidence for CP violation in D meson decays in terms of physics beyond the Standard Model. On general grounds, models in which the primary source of flavor violation is linked to the breaking of chiral symmetry (left-right flavor mixing) are natural candidates to explain this effect, via enhanced chromomagnetic operators. In the case of supersymmetric models, we identify two motivated scenarios: disoriented A-terms and split families. These structures predict other non-standard signals, such as nuclear EDMs close to their present bounds and, possibly, tiny but visible deviations in K and B physics, or even sizable flavor-violating processes involving the top quark or the stops. Some of these connections, especially the one with nuclear EDMs, hold beyond supersymmetry, as illustrated with the help of prototype non-supersymmetric models.Comment: 30 pages, 6 figure

Targeted knock-down of miR21 primary transcripts using snoMEN vectors induces apoptosis in human cancer cell lines

We have previously reported an antisense technology, 'snoMEN vectors', for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use of snoMEN vectors to target the knock-down of micro RNA primary transcripts. We document the specific knock-down of miR21 in HeLa cells using plasmid vectors expressing miR21-targeted snoMEN RNAs and show this induces apoptosis. Knock-down is dependent on the presence of complementary sequences in the snoMEN vector and the induction of apoptosis can be suppressed by over-expression of miR21. Furthermore, we have also developed lentiviral vectors for delivery of snoMEN RNAs and show this increases the efficiency of vector transduction in many human cell lines that are difficult to transfect with plasmid vectors. Transduction of lentiviral vectors expressing snoMEN targeted to pri-miR21 induces apoptosis in human lung adenocarcinoma cells, which express high levels of miR21, but not in human primary cells. We show that snoMEN-mediated suppression of miRNA expression is prevented by siRNA knock-down of Ago2, but not by knock-down of Ago1 or Upf1. snoMEN RNAs colocalise with Ago2 in cell nuclei and nucleoli and can be co-immunoprecipitated from nuclear extracts by antibodies specific for Ago2

Unconscious Thinking, Feeling and Behavior Towards Products and Brands: Introduction to a Journal of Brand Management Special Issue

This introduction reviews the motivating forces behind this issue, exploring the role of nonconscious consumer behavior in branding environments. The article establishes a foundation of unconscious research in psychology and consumer behavior, and then provides an introduction to the four articles that follow. The article concludes with a call to adopt an inclusive interpretive-positivistic stance to the study of unconscious consumer-brand behavior, attitudes and beliefs