Higgs Limit and b->s gamma Constraints in Minimal Supersymmetry

New limits on the Higgs mass from LEP and new calculations on the radiative (penguin) decay of the b->s gamma branching ratio restrict the parameter space of the Constrained Minimal Supersymmetric Standard Model (CMSSM). We find that for the low tan(beta) scenario only one sign of the Higgs mixing parameter is allowed, while the high tan(beta scenario is practically excluded, if one requires all sparticles to be below 1 TeV and imposes radiative electroweak symmetry breaking as well as gauge and Yukawa coupling unification. For squarks between 1 and 2 TeV high tan(beta) scenarios are allowed. We consider especially a new high tan(beta)=64 scenario with triple unification of all Yukawa couplings of the third generation, which show an infrared fixed point behaviour. The upper limit on the mass of the lightest Higgs in the low (high) tan(beta) scenarios is 97+-6~(120+-2) GeV, where the errors originate predominantly from the uncertainty in the top mass.Comment: latex + 6 eps figs, 10 pages, IEKP-KA/98-08; References updated in replacement + 1 figure concerning triple Yukawa unification added for final publication in Phys. Let

Advances and prospects of frequency doublers based on periodically poled silica fibres

Record high efficient frequency doublers in periodically poled silica fibres are demonstrated for light generation at 532 nm and 775 nm. The onset of nonlinear conductivity is shown to limit the maximum χ(2) in glass

Second-harmonic vortex generation with a poled glass

A Simple method for nonlinear vortex generation is presented. Spin-to-Orbital transfer with total angular momentum conservation between photons at the fundamental and at the second-harmonic frequency is demonstrated

A global fit to the anomalous magnetic moment, b -> Xs-gamma and Higgs limits in the constrained MSSM

New data on the anomalous magnetic moment of the muon together with the b -> Xsgamma decay rate and Higgs limits are considered within the supergravity inspired constrained minimal supersymmetric model. We perform a global statistical X² analysis of these data and show that the allowed region of parameter space is bounded from below by the Higgs limit, which depends on the trilinear coupling and from above by the anomalous magnetic moment an

The supersymmetric interpretation of the EGRET excess of diffuse Galactic gamma rays

Recently it was shown that the excess of diffuse Galactic gamma rays above 1 GeV traces the Dark Matter halo, as proven by reconstructing the peculiar shape of the rotation curve of our Galaxy from the gamma ray excess. This can be interpreted as a Dark Matter annihilation signal. In this paper we investigate if this interpretation is consistent with Supersymmetry. It is found that the EGRET excess combined with all electroweak constraints is fully consistent with the minimal mSUGRA model for scalars in the TeV range and gauginos below 500 GeV.Comment: 11 pages, 6 figures, extended version with more figures, as accepted for publication in Phys. Letters

Non-universal gaugino masses: a signal-based analysis for the Large Hadron Collider

We discuss the signals at the Large Hadron Collider (LHC) for scenarios with non-universal gaugino masses in supersymmetric (SUSY) theories. We perform a multichannel analysis, and consider the ratios of event rates in different channels such as $jets + {E}_T/$, $same$ - and $opposite$-$sign dileptons$ $+jets+ {E}_T/$, as well as $single-lepton$ and $trilepton$ final states together with $jets + {E}_T/$ . Low-energy SUSY spectra corresponding to high-scale gaugino non-universality arising from different breaking schemes of SU(5) as well as SO(10) Grand Unified (GUT) SUSY models are considered, with both degenerate low-energy sfermion masses and those arising from a supergravity scenario. We present the numerical predictions over a wide range of the parameter space using the event generator {\tt Pythia}, specifying the event selection criteria and pointing out regions where signals are likely to be beset with backgrounds. Certain broad features emerge from the study, which may be useful in identifying the signatures of different GUT breaking schemes and distinguishing them from a situation with a universal gaugino mass at high scale. The absolute values of the predicted event rates for different scenarios are presented together with the various event ratios, so that these can also be used whenever necessary.Comment: 54 pages, 18 figure

MSSM Predictions of the neutral Higgs boson masses and LEP II production cross sections

Within the framework of the Minimal Supersymmetric Standard Model (MSSM) the Higgs masses and LEP II production cross sections are calculated for a wide range of the parameter space. In addition, the parameter space restricted by unification, electroweak symmetry breaking and other low energy constraints is considered in detail, in which case the masses of all SUSY partners can be estimated, so that their contributions to the radiative corrections can be calculated. Explicit analytical formulae for these contribution are derived. The radiative corrections from the Yukawa couplings of the third generation are found to dominate over the contributions from charginos and neutralinos. Large Higgs mass uncertainties are due to the top mass uncertainty and the unknown sign of the Higgs mixing parameter. For the low tanb scenario the mass of the lightest Higgs is found to be below 103 GeV for a top mass below 190 GeV. The cross section at a LEP energy of 192 GeV is sufficient to find or exclude this low tanb scenario for a top mass below 180 GeV. For the high tanb scenario only a small fraction of the parameter space can be covered, since the Higgs mass is predicted between 105 and 125 GeV in most cases. At the theoretically possible LEP II energy of 205 GeV part of the parameter space for the large tanb scenario would be accessible.Comment: latex + 6 eps figs, 22 pages, final versio

Universal DNA methylation age across mammalian tissues

DATA AVAILABILITY STATEMENT : The individual-level data from the Mammalian Methylation Consortium can be accessed from several online locations. All data from the Mammalian Methylation Consortium are posted on Gene Expression Omnibus (complete dataset, GSE223748). Subsets of the datasets can also be downloaded from accession numbers GSE174758, GSE184211, GSE184213, GSE184215, GSE184216, GSE184218, GSE184220, GSE184221, GSE184224, GSE190660, GSE190661, GSE190662, GSE190663, GSE190664, GSE174544, GSE190665, GSE174767, GSE184222, GSE184223, GSE174777, GSE174778, GSE173330, GSE164127, GSE147002, GSE147003, GSE147004, GSE223943 and GSE223944. Additional details can be found in Supplementary Note 2. The mammalian data can also be downloaded from the Clock Foundation webpage: https://clockfoundation.org/MammalianMethylationConsortium. The mammalian methylation array is available through the non-profit Epigenetic Clock Development Foundation (https://clockfoundation.org/). The manifest file of the mammalian array and genome annotations of CpG sites can be found on Zenodo (10.5281/zenodo.7574747). All other data supporting the findings of this study are available from the corresponding author upon reasonable request. The chip manifest files, genome annotations of CpG sites and the software code for universal pan-mammalian clocks can be found on GitHub95 at https://github.com/shorvath/MammalianMethylationConsortium/tree/v2.0.0. The individual R code for the universal pan-mammalian clocks, EWAS analysis and functional enrichment studies can be also found in the Supplementary Code.SUPPLEMENTARY MATERIAL 1 : Supplementary Tables 1–3 and Notes 1–6.SUPPLEMENTARY MATERIAL 2 : Reporting SummarySUPPLEMENTARY MATERIAL 3 : Supplementary Data 1–14.SUPPLEMENTARY MATERIAL 4 : Supplementary Code.Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.https://www.nature.com/nataginghj2024Zoology and EntomologySDG-15:Life on lan