The start of systems biology in Ukraine

The first laboratory of Systems Biology in Ukraine (IMBIG NASU) represents a track record of its scientific results. They include the pioneered development of a web-based tool for genome-wide surveys of eukaryotic promoters for the presence of transcription factors binding sites (COTRASIF); the deciphered mechanisms of the fine-tuned and balanced response of primary hepatocytes to interferon alpha levels recorded after partial hepatectomy; the elaboration of a novel method of gene regulatory network inference compatible with GRID environment and the development of a stoichiometric model of folate-related one carbon unit metabolism in human placenta and its application for the characteristics of the system’s behavior as a whole at different human pathologies.Представлено наукові здобутки першої в Україні (ІМБіГ НАН України) лабораторії системної біології. Вони включають створення веб-інструменту для всегеномного пошуку сайтів зв’язування транскрипційних факторів у промоторах евкаріотних генів; розкриття тонко збалансованого механізму відповіді первинних гепатоцитів на дію інтерферону альфа в дозі, зареєстрованій на першому етапі регенерації печінки після часткової гепатектомії; розробку нового методу інференції мережі генної регуляції для його використання в середовищі ГРІД і створення стехіометричної моделі фолатного циклу у плаценті людини для характеристики поведінки системи за різних патологічних станів.Представлены научные наработки первой в Украине (ИМБиГ НАН Украины) лаборатории системной биологии. Они включают создание веб-инструмента для всегеномного поиска сайтов связывания транскрипционных факторов в промоторах эукариотических генов; раскрытие тонко сбалансированного механизма ответа первичных гепатоцитов на действие интерферона альфа в дозе, регистрируемой в печени на раннем этапе после частичной гепатэктомии; разработку нового метода инференции сетей генной регуляции для его использования в среде ГРИД и создание модели фолатного цикла в плаценте человека для характеристики поведения системы при разных патологических состояниях

ENVIRONMENTS OF SOUTHWESTERN SIBERIA AND NORTHWESTERN MONGOLIA IN THE LATE HOLOCENE (BASED ON THE LAKE SEDIMENTS STUDY)

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Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

New possibilities of pharmacotherapy in cardiovascular patients with mental disorders

Objective. To study the efficacy and tolerability of the drugs pantogam active and phenotropil in mild neurotic, somatoform, stress-induced and depressive disorders developed in patients with cardiovascular diseases. Material and methods. The effect of pantogam active was assessed in an open study. The main group of patients (n=35) treated with phenotropil during 12 weeks was compared to the comparison group (n=35). Patient’s status was evaluated using psychometric (CGI, HDRS etc) and adverse effect scales. Results and conclusion. Statistically significant results demonstrated the advantages of pantogam active has advantage on a number of values. The treatment effect of pantogam active gradually increased while the effect (in particular anxiolytic one) of phenotropil decreased after 4—8 weeks of treatment. The tolerability of both drugs was satisfactory. © 2014, Media Sphera. All rights reserved

The anatomic and physiologic parameters and evaluation of physical training of students.

Anatomico-physiological parameters of students were reviewed. 216 students took part in research. The level of their physical training was assessed. Deviations from norms on weight are defined; most often meeting indicators of growth and weight are specified. The factor of correlation between these indicators was described. The factual and tabular data of anthropometric indicators was compared; the index of Rufe was described. Satisfactory level of health and insufficient level of preparation of students was disclosed

New possibilities of pharmacotherapy in cardiovascular patients with mental disorders

Objective. To study the efficacy and tolerability of the drugs pantogam active and phenotropil in mild neurotic, somatoform, stress-induced and depressive disorders developed in patients with cardiovascular diseases. Material and methods. The effect of pantogam active was assessed in an open study. The main group of patients (n=35) treated with phenotropil during 12 weeks was compared to the comparison group (n=35). Patient’s status was evaluated using psychometric (CGI, HDRS etc) and adverse effect scales. Results and conclusion. Statistically significant results demonstrated the advantages of pantogam active has advantage on a number of values. The treatment effect of pantogam active gradually increased while the effect (in particular anxiolytic one) of phenotropil decreased after 4—8 weeks of treatment. The tolerability of both drugs was satisfactory. © 2014, Media Sphera. All rights reserved

Strategic development of the textile industry in the context of the use of green manufacturing and logistics technologies

The purpose of this article is to summarize a systematic approach to the implementation and development of green technologies in the global textile industry. The key conclusions are as follows: • along with environmental harm caused by a manufacturing component of the textile industry, a logistics component also has a very significant impact on the environment; • the issues of transition of the global textile industry to an environmentally responsible way of development should be addressed systematically through a comprehensive transformation of manufacturing and logistics components; • green manufacturing technologies, supplemented by "green" logistics technologies, as well as the transformation of consumer demand towards environmentally sound textile products, ensure a systemic and synergetic effect, which is expressed in a significant reduction of anthropogenic and antropogenic load on the environment. © 2017

Strategic development of the textile industry in the context of the use of green manufacturing and logistics technologies

The purpose of this article is to summarize a systematic approach to the implementation and development of green technologies in the global textile industry. The key conclusions are as follows: • along with environmental harm caused by a manufacturing component of the textile industry, a logistics component also has a very significant impact on the environment; • the issues of transition of the global textile industry to an environmentally responsible way of development should be addressed systematically through a comprehensive transformation of manufacturing and logistics components; • green manufacturing technologies, supplemented by "green" logistics technologies, as well as the transformation of consumer demand towards environmentally sound textile products, ensure a systemic and synergetic effect, which is expressed in a significant reduction of anthropogenic and antropogenic load on the environment. © 2017