Clinical features of subacute course of radiation disease

Aim: to show the clinical features of subacute course of subacute course of radiation disease and how they differ from the typical manifestations of acute and chronic radiation syndrome. Material and methods. Materials of the Burnasyan Federal Medical and Biophysical Center Register of acute radiation disease (ARS) in the Former USSR and Russia and Materials of a Burnasyan Federal Medical and Biophysical Center database of workers "Mayak" with chronic radiation syndrome (CRS) were analyzed. There were selected 22 patients with radiation syndrome due to fractionated or prolonged accidental exposure (the main group of patients). There were formed two subgroups for comparison: patients with a typical marrowy syndrome of acute radiation disease and with chronic radiation syndrome. Statistical analysis of results was made by means of statistical software package Statistica v. 6.1 for Windows (StatSoft Inc., USA) and Microsoft Excel 2010. Results. It was found that subacute course of radiation syndrome is possible under radiation exposure with medium dose rate in the range of 0.1-0.3 Gy/day Early symptoms of the disease as a primary reaction symptoms are completely absent. First complaints appeared in the earliest one month after the start of work in adverse conditions, on the average 6 months. In the period of formation there is a pancytopenia in the peripheral blood. Duration of the formation period was also determined. In this case radiation cataracts in patients are not observed. After the termination of radiation exposure hematopoietic recovery is slow, possibly incomplete with a high probability of hemoblastosis development. Conclusions. There has been described the subacute course of radiation disease by analyzing the clinical material of patients with radiation syndrome, there has been analyzed the clinical criteria that distinguish subacute radiation syndrome from acute and chronic

Features of medical examination of suitability of employees for working at nuclear power plant after myocardial infarction

Aim: examination of professional qualification of NPP personnel suffering from post-infarction cardiosclerosis, to work with sources of ionizing radiation with the formation of proposals of amendments to the order of the health Ministry from 12.04.2011 No. 302-N. Material and Methods. Medical database by making indicators with individual registration forms made from 269 persons with postinfarction cardiosclerosis staff of main and auxiliary production of Russian NPPs (272 men and 7 women), average age of the examined patients was 56.2 ± 7.0 years; the total number the analyzed characteristics, reflected in the generated database was 49 lines. Results. The results of the risk stratification of sudden cardiac death with the formation of risk groups and proposed draft amendments to the Order of the health Ministry of the Russian Federation of 12 April 2011 No. 302-n order differential approach to the assessment of competency in hazardous conditions patients with postinfarction cardiosclerosis. Conclusion. On the basis of clinical examination and assessment of risk for sudden cardiac death, it is necessary to make changes in the List of medical contraindications for admission to works in accordance with section 4 of Annex No. 3 to the Order of Ministry of health, April 12, 2011 No. 302 n in terms of access to work with ionizing radiation to persons suffering from post-infarction cardiosclerosis; to identify among patients postpartum cardiosclerosis persons not fit to continue the work in contact with sources of ionizing radiation, it is necessary referral to additional examination in occupational disease Centers in accordance with the Order of Ministry of health, April 12, 2011 No. 302 N

Influence of Polymers on the Physicochemical Properties of Benzonal in Solid Dispersions

Abstract: The influence of solid dispersions (SDs) on some physicochemical properties of benzonal is studied. Investigated: benzonal and its SD with polyvinylpyrrolidone-10 000 (PVP), polyethylene glycol-1500 (PEG), β-cyclodextrin (CD). The preparation of SD by the solvent removal method increases the solubility and dissolution rate of benzonal in water. The solubility increases by 3.5–5.5 times; and the speed of dissolving, by 4.0–10.0 times. The complex of physical and chemical research methods suggests that the preparation of an SD with the studied polymers is accompanied by loss of crystallinity and formation of a solid solution of benzonal in the polymer, as well as solubilization and formation of colloidal solutions of benzonal during subsequent dissolution of SD in water. The results obtained can be used in the development of fast-dissolving benzonal tablets with increased release and bioavailability. © 2020, Allerton Press, Inc

Carbohydrates determination in the snowdrops (Galanthus L.) herbal pharmaceutical substances by TLC and UV-spectrophotometry

Plants of Galanthus L. genus (snowdrops) used in Russian medicine for obtaining neurological and cardiovascular remedies, contain different types of carbohydrates (polysaccharides, monosaccharides) as additional biological active substances group. In present research the carbohydrate composition and content were investigated in the snowdrops herbal pharmaceutical substances (Galanthus woronowii Losinsk, Galanthus nivalis L.). Optimal conditions for TLC analysis, the extraction of crude herbal drugs, were determined; spectrophotometric procedures for quantifying the total carbohydrate content in terms of monosaccharides (fructose, glucose) were successfully developed. The results of the investigation can be used in quality control and standardization of crude herbal drugs containing carbohydrates, and for inclusion in pharmacopoeial monographs. © RJPT All right reserved

Перспективы применения лекарственных форм нифедипина в медицине и фармации (обзор)

The article describes aspects of the use of nifedipine. Nifedipine is an active substance that has not lost its relevance in modern medicine and pharmacy. The prospects for the use of existing drugs nifedipine are presented. The possibility of creating new dosage forms containing solid dispersions of nifedipine is being considered.Приведены аспекты применения нифедипина. Представлены перспективы использования существующих препаратов нифедипина. Рассмотрена возможность создания новых лекарственных форм, содержащих твердые дисперсии нифедипина

Pharmacognostic, phytochemical and ethnopharmacological potential of Cyclamen coum Mill.

Background: This review focuses on characterization of Cyclamen coum Mill. (Myrsinaceae), composition and content of biologically active substances presented in the above-ground and underground parts, reporting use of this plant in traditional medicine, predicting possible pharmacotherapeutic effects. Materials and Methods: Various electronic search engines such as Google, Google scholar, scientific literature, electronic databases such as e-Library, Scopus, Web of Science, Pubmed had been searched and data obtained. Results: Cyclamen L. is classified in the Myrsinaceae family now. It is a typical element of the Mediterranean flora. C. coum. is a species characteristic of the Caucasus and Crimea with rounded leaves and rounded corolla lobes, bright and pink-purple flowers. Chemical composition of biologically active substances of C. coum was described in sufficient detail. C. coum contains saponins (coumoside A, coumoside B, cyclaminorin, deglucocyclamin, cyclacoumin, and mirabilin lactone), sterols (stigmasterol and other related compounds), piperidine alkaloid (2-β-D-glycopyranosyl-2-undecil-3,5-dihydroxy-6-carboxypiperidine), flavonoids, phenols, tannins, cardiac glycosides. Antioxidant, antibacterial, antifungal, and antitumor activities are established for different C. coum extracts. Conclusion: C. coum can be used for the production of potential anticancer, antibacterial and antifungal drugs. It should be noted that more pharmacognostic, pharmacological studies are needed for providing further information to use this medicinal plant in the official medicine. Also, standardization procedures for a crude herbal drug should be developed. © 2020 Phcogj.Com

Pharmacopoeial analysis of inulin-containing medicinal plant raw materials and drugs

Background: Today, there are some unresolved issues and discussions concerning inulin quantitative determination in medicinal plant raw materials (MPRM). MPRM containing polyfructans or fructosans (inulin and others) are rather complex multicomponent matrixes with many interacting compounds. The article discusses the prospects for further standardization of inulin-containing pharmacopoeial MPRM that include, in addition to polysaccharides (inulin), other biologically active compounds with pharmacological activity. Materials and Methods: Different types of search tools such as Google scholar, Google, scientific literature, normative documentation of Russian Federation (State Pharmacopoeia of Russian Federation IV edition and others) electronic databases such as e-Library, Scopus, Web of Science, Pubmed had been searched and data obtained. Results: The pharmacopoeial spectrophotometric procedures of inulin determination in the Russian Federation are approved in a version that does not fully satisfy modern standardization criteria. Regulatory changes required in the near future. Conclusion: Undoubtedly, to determine inulin quantitatively, it is necessary to modify the existing spectrophotometric procedures and introduce an additional alternative, more specific HPLC-RID (or similar) ones. © 2020 Phcogj.Com

Composition of biologically active compounds, biological and pharmacological activity of the three-part beggarticks (Bidens tripartita L.)

This reviewcontains the analysis data on phytochemical composition ofthree-part beggarticks(Bidens tripartitaL.) and full biological activity spectrum of themedicinalraw material. Flavonoids, essentialoils, phenolcarboxylic acids, polysaccharides, aromatic hydroxy aldehydes, coumarins, tannins, and polyacetylenes are biologically active substances (BAS)ofB. tripartita.Various BAS cause multiple pharmacological and biological effects of theplant. Extracts possess antimycotic, antiinflammatory, antithrombotic, antiradical, antioxidant, antibacterial, antidiabetic, antiulcerogenic, and antitumor effects. The extracts are also ofanalgesic, antipyretic, antiallergic, hepatoprotective, immunostimulating,and hypotensive pharmacological effects. There is also a possibility to inhibit the main enzymes as well as to protect DNA. The B. tripartita medicinal raw material is of great importance for development and making of new drugs

Coltsfoot leaves (Tussilago farfara L.) a promising source of essential amino acids

Objective: Free and bounded amino acids are one of the valuable biologically active substances (BAS) containing in medicinal plants with other BAS groups. The research aims to determine the profile and content of free and bounded amino acids in coltsfoot leaves infusion by HPLC-UV, as well as suggest alternative ways to use it in medicine. Materials and methods: Coltsfoot leaves (crushed herbal drug) were used as plant material for preparing infusion and analysis. Amino acids profile and content were analyzed by RP-HPLC-UV after pre-column derivatization with o-phthalaldehyde and 3-mercaptopropionic acid (OPA) (derivatization of primary amines) and with fluorenylmethyloxycarbonyl (FMOC) (secondary amines). The sources of scientific literature concerning the amino acid composition of crushed herbal drugs were also studied. Results: 10 free and 13 bounded amino acids were identified in coltsfoot leaves infusion. Total content was 44.04±2.20 mg/g (Arg > Tyr > Gln > Ala > Asn > Met > Ile > Val > Lys > Leu) and 57.79±2.89 mg/g (Arg > Gln > Lys > Tyr > Gly > Asn > Val > Thr > Ala > Ile > Nva > Leu > Met) respectively. Content of essential amino acids - 0,89±0,04 mg/g (5 free); 9,58±0,48 mg/g (5 bounded). Conclusions: Since the coltsfoot leaves contain a significant amount of arginine, studies involving the prevention and adjunctive treatment of viral diseases, including SARS-CoV-2 virus infection (COVID-19), are promising. © 2020 EManuscript Technologies. All rights reserved