Composition of Fluids Responsible for Gold Mineralization in the Pechenga Structure-Imandra-Varzuga Greenstone Belt, Kola Peninsula, Russia.

This study presents the first fluid inclusion data from quartz of albite–carbonate–quartz altered rocks and metasomatic quartzite hosting gold mineralization in the Pechenga structure of the Pechenga– Imandra–Varzuga greenstone belt. A temperature of 275–370°C, pressure of 1.2–4.5 kbar, and the fluid composition of gold-bearing fluid are estimated by microthermometry, Raman spectroscopy, and LA-ICP-MS of individual fluid inclusions, as well as by bulk chemical analyses of fluid inclusions. In particular, the Au and Ag concentrations have been determined in fluid inclusions. It is shown that albite–carbonate–quartz altered rocks and metasomatic quartzite interacted with fluids of similar chemical composition but under different physicochemical conditions. It is concluded that the gold-bearing fluid in the Pechenga structure is similar to that of orogenic gold deposits

Features of mineral crystallization at different stages of the magmatism evolution of the gorely volcano (Kamchatka): Data on melt and fluid inclusions

Studies of melt and fluid inclusions and minerals as well as computational modeling (based on the data on the composition of melt inclusions, clinopyroxenes, and amphiboles) gave an insight into the physicochemical parameters of magmatic systems during the evolution of the precaldera Pra-Gorely Volcano and during the subsequent formation of rock complexes of the Young Gorely Volcano. The estimated temperatures of crystallization of olivine, clinopyroxene, and plagioclase phenocrysts (1115–1260 ºС) and amphibole (740–890 ºС) are in agreement with the earlier published data on the magmatism of the Gorely Volcano. Computational modeling based on the compositions and homogenization temperatures of melt inclusions showed that the established depth interval of mineral crystallization (21.0–1.5 km) with pressures of 7.0–0.5 kbar can be divided into two ranges, 21–15 km and 9.0–1.5 km. Both the Pra-Gorely and Young Gorely volcanoes have magma chambers in these depth ranges. The Pra-Gorely Volcano is characterized by higher temperatures of mineral crystallization (1240–1190 ºС) as compared with the Young Gorely Volcano (1190–1125 ºС). The presence of primary fluid inclusions with low-density CO2 and of syngenetic primary melt inclusions in plagioclase of the Pra-Gorely Volcano indicates that the mineral crystallized from a heterophase melt. At the same time, the cores of plagioclase phenocrysts formed from a homogeneous melt. A drastic drop in pressure led to the phase separation of magma throughout the magma column (upper and lower chambers) and to the growth of zones saturated with CO2 fluid inclusions in the plagioclase crystals formed from a two-phase melt. The subsequent closure of the system and the disappearance of CO2 phase resulted in the growth of plagioclase from a homogeneous melt

Theoretical Research of Coal Gasification Products Burning in Boilers at Tomsk Thermal Power Plant-3

Mathematical modeling of primary fuel change into power gas in power generating boiler with productivity of steam 160 t\h was done. Research of aggregate work on some power modes was completed. Characteristic curves of efficiency coefficient at different loads and ratio on power and natural gases burning were made. Practicability of power gas use as fuel was proved

Theoretical Research of Coal Gasification Products Burning in Boilers at Tomsk Thermal Power Plant-3

Mathematical modeling of primary fuel change into power gas in power generating boiler with productivity of steam 160 t\h was done. Research of aggregate work on some power modes was completed. Characteristic curves of efficiency coefficient at different loads and ratio on power and natural gases burning were made. Practicability of power gas use as fuel was proved

Bacterial vaginosis: comparative effectiveness of treatments with 5-nitroimidazole derivatives

I.G. Kutsenko, I.O. Borovikov, E.I. Kravtsova, S.K. Batmen, A.S. Magay, O.I. Borovikova, V.A. Avakimyan, A.A. Andreeva Kuban State Medical University, Krasnodar, Russian Federation Aim: to perform a comparative analysis of clinical and microbiological efficacy and compliance to treatment with 5-nitroimidazole derivatives in patients with bacterial vaginosis (BV). Patients and Methods: this prospective open randomized study included 96 patients diagnosed with BV. The patients were divided into two groups: group 1 (n=48) received antimicrobials — oral secnidazole 2000 mg in a single dose (decontamination therapy) and vaginally administered L. casei rhamnosus Doderleini for 14 days to restore the vaginal flora (contamination therapy); group 2 (n=48) received oral metronidazole 500 mg twice daily for 7 days (decontamination therapy) and vaginally administered L. casei rhamnosus Doderleini for 14 days (contamination therapy). Clinical efficacy was evaluated one and six months after the end of therapy. The treatment efficacy criteria included the absence of specific patient's complaints, clinical and laboratory findings (pH; Nugent score), and PCR results. The compliance to treatment was assessed using clinical and psychological tests (the Morisky-Green Scale and the Modified Medication Compliance Scale). The assessment of safety profile was based on the analysis of adverse events (AE). Results: one month after the end of treatment all patients had a statistically significant (p&lt;0.05) reduction in the prevalence of BV symptoms (unpleasant vaginal odor, pathological vaginal discharge, itching, dyspareunia, dysuria events) as compared to those at the baseline. At month 1 after the end of treatment, subgroup analysis did not demonstrate a significant difference. Six months after the end of treatment the proportion of the group 1 patients who had pathological vaginal discharge with specific odor increased to 16.7%, while in the group 2 patients it reduced to 8.3% (p&lt;0.05). Microbiological assessment (PCR) of the combination therapy in two groups of patients with BV demonstrated a high antibacterial efficacy of 5-nitroimidazole derivatives during the first month of follow-up. The patients were considered fully compliant if they scored 4 on the Morisky — Green Scale and scored 30 on the Modified Medication Compliance Scale of V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology. The percentage of full compliance was 76.2±2.8% in the group 1 patients and 93.75±3.25% in the group 2 patients. Conclusion: a high comparative clinical and microbiological effectiveness of treatments with 5-nitroimidazole derivatives (metronidazole and secnidazole) with further vaginal colonization with lactobacilli was demonstrated in patients with bacterial vaginosis. Full medication compliance was higher in patients receiving secnidazole for BV treatment. Keywords: bacterial vaginosis, vaginal microbiota, vaginal discharge, 5-nitroimidazole derivatives, metronidazole, secnidazole, compliance. For citation: Kutsenko I.G., Borovikov I.O., Kravtsova E.I. et al. Bacterial vaginosis: comparative effectiveness of treatments with 5-nitroimidazole derivatives. Russian Journal of Woman and Child Health. 2023;6(2):78–87 (in Russ.). DOI: 10.32364/2618-8430-2023-6-2-78-87. </p