8 research outputs found
Giant Planet Formation and Migration
© 2018, The Author(s). Planets form in circumstellar discs around young stars. Starting with sub-micron sized dust particles, giant planet formation is all about growing 14 orders of magnitude in size. It has become increasingly clear over the past decades that during all stages of giant planet formation, the building blocks are extremely mobile and can change their semimajor axis by substantial amounts. In this chapter, we aim to give a basic overview of the physical processes thought to govern giant planet formation and migration, and to highlight possible links to water delivery.S.-J. Paardekooper is supported by a Royal Society University Research Fellowship. A. Johansen is supported by the Knut and Alice Wallenberg Foundation, the Swedish Research Council (grant 2014-5775) and the European Research Council (ERC Starting Grant 278675-PEBBLE2PLANET)
Relationship of human papillomavirus with seborrheic keratosis of the female genital tract - a case-series and literature review
Seborrheic keratoses (SKs) are benign
lesions of uncertain etiology, which can develop in both
genital and extra-genital locations. For genital SKs there
has been conjecture about the pathogenic role of human
papillomavirus (HPV), in view of the frequent
association of this virus with genital lesions.
In light of the potential consequences on patient
management, we investigated the relationship between
HPV and SKs of the female genital tract (FGT). For this,
we evaluated the current evidence on this relationship by
performing an in-depth review of the literature.
Furthermore, to add to the evidence on this association,
we investigated the presence of HPV in a series of
vulvar SKs (n=15), using a novel multimodal approach.
This involved whole tissue section-polymerase chain
reaction (WTS-PCR) using SPF10-DEIA-LiPA25 for
HPV detection and genotyping. In addition,
immunohistochemistry (IHC) was performed with
cellular biomarkers p16 and MIB-1, and viral biomarker
E4, to augment HPV-testing. Finally, laser-capture
microdissection-PCR (LCM-PCR) was performed to
locate HPV to specific lesional cells, and to rule out
incidental detection of resident HPV with WTS-PCR.
Our findings from the literature review as well as the
case-series are presented