Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

The influence of heat treatments on the microstructural parameters of P92 steel

The microstructural parameters (dislocation density, martensite lath width, precipitate diameters, and volume fractions) have been measured for the 9%Cr steel P92 (NF616) after different heat treatments. The austenitising temperatures were 970, 1070, and 1145 degreesC and the tempering temperatures 715, 775, and 835 degreesC, Increasing the austenitising temperature led to an increase in the austenite grain size and in the martensite lath width, but no significant effect on the tensile properties at 20, 600, and 650 degreesC was observed. The creep strength was, however, reduced by tempering at 835 degreesC due to rapid recovery of the martensitic structure with a sharp decrease in dislocation density, The lowest creep strength was found for the P92 steel subjected to a heat treatment that produced a fully ferritic microstructure; the secondary creep rate was four orders of magnitude higher than that of the steel in the usual martensitic condition

Untersuchung der Eigenschaften des 9%-Chromstahles vom Typ 9Cr-0.5Mo-1.8W-V-Nb im Hinblick auf seine Verwendung als Rohrleitungsstahl und Kesselbaustahl unter erhöhten Temperaturen

In an extensive testing programme, the microstructure, tensile and impact properties, creep behaviour and the stress rupture strength of two heats of the tungsten-containing 9% chromium steel NF616 have been investigated. The creep rapture properties of weldments, one with a matching filler and another with a filler of composition similar to that of the steel E 9 1 1, and of weld simulations of the softened heat affected zone were determined and compared with those of the basis steel. The toughness of the weld metal and the HAZ of weldments was also investigated. The tendency for embrittlement of the coarse grained HAZ was assessed using weld simulation specimens. Alongside the size and distribution of precipitates (M$_{23}$ C$_{6}$, MX and Laves phase), the dislocation density was found to be the most significant structural parameter with respect to the long term strength properties. Tempering at temperatures just above the A$_{C}$, temperature, even for only a few seconds as used in the softened HAZ weld simulation, led to a considerable decrease in the creep resistance compared with the normal heat treatment, which explains the susceptibility of weldments to type IV cracking in weep tests. The creep behaviour depended on the applied stress, a Norton stress exponent of 16 being found for the high stress region and 6 for the low stress region. This observation must be taken into account in the extrapolation of data to long times; an overemphasis on test data obtained at high stresses can lead to an overestimation of the stress rupture strength. Although the weld metal of the matching filler weldment was found to be relatively brittle at room temperature, the coarse grained HAZ impact strength was high. A post weld heat treatment did not lead to embrittlement. The steel investigated may be used as boiler tubes and steam pipes operating at temperatures up to 620 $^{\circ}$C. The results of continuing creep rupture tests should be awaited before a general approval of the steel can be given