11 research outputs found
A single institution experience on the correlation of Kwak Thyroid Imaging Reporting and Data System Score (Kwak TIRADS) and Malignancy of Thyroid Nodules seen in a Tertiary Hospital Setting
Objective: The purpose of this study is to determine the diagnostic accuracy of a surgeon-performed thyroid ultrasound reported using Kwak Thyroid Imaging Reporting and Data System (Kwak TIRADS) in identifying thyroid malignancy.
Patients and Methods: This is a retrospective cohort study of patients who underwent preoperative thyroid ultrasound by a surgeon and subsequently underwent thyroidectomy from January 2018 – March 2020 in UP-PGH, Department of Surgery. Correlation between ultrasonographic features and Kwak TIRADS categories with malignancy were analyzed using chi square (univariate analysis) and logistic regression (multivariate analysis).
Results: A total of 174 patients with thyroid nodules at least 1 cm in widest diameter were included in the study. There were 85 patients with malignant thyroid disease and 89 patients with benign nodules. Solid composition, hypoechogenicity/marked hypoechogenicity, lobulated/irregular margins, rim/microcalcifications, and shape taller than wide were significantly associated with thyroid malignancy on univariate analysis (all p-values < 0.001). However, only solid composition, hypoechogenicity/marked hypoechogenicity, and irregular/lobulated margins were significantly associated with thyroid malignancy on multivariate analysis (p-values < 0.001, 0.002 and 0.011, respectively). On the other hand, Kwak TIRADS categories 4a and above are significantly associated with thyroid malignancy (all p-values < 0.001), with the risk of malignancy increasing as the Kwak TIRADS category increases. Sensitivity, specificity, PPV and negative NPV are optimal when cutoff for further workup is set at Kwak TIRADS 4a.
Conclusions: A surgeon performed thyroid ultrasonography reported using Kwak TIRADS classification can be utilized as a guide in the management of thyroid nodules. The consideration of Kwak TIRADS 4a as a cutoff level for further workup is recommended
ALFALFA extragalactic HI source catalog
VizieR online Data Catalogue associated with article published in journal Astronomical Journal (AAS) with title 'The Arecibo Legacy Fast ALFA survey: The ALFALFA extragalactic HI source catalog.' (bibcode: 2018ApJ...861...49H
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Results from beam tests of MEGA's low-mass, high-rate cylindrical MWPCs
One of the leading experimental projects at LAMPF has been the MEGA experiment. This is an experiment to search for the rare decay {mu} {yields} e{gamma} with a sensitivity of 10{sup {minus}13}. A prime component of this project has been the design and construction of high-rate, low mass MWPCs for the tracking of positrons from muon decay. With rate capabilities of 2 {times} 10{sup 4} e{sup +}/mm{sup 2}/s and a thickness of 3 {times} 10{sup {minus}4} radiation lengths, these chambers are state-of-the-art cylindrical MWPCs. Cylindrical chambers of this size (0.9 m{sup 2}) and thinness have never been previously constructed. The MEGA project at LAMPF has recently succeeded in building chambers with these necessary performance characteristics as demonstrated by data taken from muon decays, cosmic rays, and sources
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DUSEL Theory White Paper
The scientific case for a Deep Underground Science and Engineering Laboratory [DUSEL] located at the Homestake mine in Lead, South Dakota is exceptional. The site of this future laboratory already claims a discovery for the detection of solar neutrinos, leading to a Nobel Prize for Ray Davis. Moreover this work provided the first step to our present understanding of solar neutrino oscillations and a chink in the armor of the Standard Model of particle physics. We now know, from several experiments located in deep underground experimental laboratories around the world, that neutrinos have mass and even more importantly this mass appears to fit into the framework of theories which unify all the known forces of nature, i.e. the strong, weak, electromagnetic and gravitational. Similarly, DUSEL can forge forward in the discovery of new realms of nature, housing six fundamental experiments that will test the frontiers of our knowledge: (1) Searching for nucleon decay (the decay of protons and neutrons predicted by grand unified theories of nature); (2) Searching for neutrino oscillations and CP violation by detecting neutrinos produced at a neutrino source (possibly located at Brookhaven National Laboratory and/or Fermi National Laboratory); (3) Searching for astrophysical neutrinos originating from the sun, from cosmic rays hitting the upper atmosphere or from other astrophysical sources, such a supernovae; (4) Searching for dark matter particles (the type of matter which does not interact electromagnetically, yet provides 24% of the mass of the Universe); (5) Looking for the rare process known as neutrino-less double beta decay which is predicted by most theories of neutrino mass and allows two neutrons in a nucleus to spontaneously change into two protons and two electrons; and (6) Searching for the rare process of neutron- anti-neutron oscillations, which would establish violation of baryon number symmetry. A large megaton water Cherenkov detector for neutrinos and nucleon decay, located in DUSEL and roughly 20 times the size of current detectors, can perform the first three of these experiments. The last 3 can utilize the unique environment afforded by DUSEL to perform the most sensitive tests to date. Any one of these experiments can greatly increase our knowledge of nature. The Deep Underground Science and Engineering Laboratory (DUSEL), with a Large Megaton Size Detector, is desperately needed to address a set of fundamental issues in particle and astrophysics