Correlation analysis between journal metrics and subscription price for selected journals

The given article gives an account on the correlation analysis between the journal metrics (SNIP, SJR, IF) and the subscription price for two groups of journals (114 Economics journals and 150 Mathematics and Computer Science journals) which were presented on Elsevier website in October 201

Cross correlation analysis between SNIP, SJR and if for selected journals

The cross correlation analysis was presented in the given article and linear regression equations between various types of journal metrics (SNIP, SJR, IF) were obtained for economics and mathematics and computer science journal

Structural and transport characteristics of substituted bismuth niobates

The results of studying solid solutions with the composition of Bi 3Nb1 - y Zr y O7 ± δ, Bi2.95Y0.05Nb1 - y Zr y O 7 ± δ (y = 0-0.5; Δy = 0.1), and Bi 6.95Y0.05Nb2 - y Zr y O 15.5 (y = 0.1-1; Δy = 0.1) are presented. XRD and electron microscopy with X-ray microanalysis are used to determine the homogeneity regions of solid solutions; crystallochemical parameters are calculated. It is shown that irrespective of the ratio of Bi: Nb, two cubic phases are formed at an increase in the dopant amount. One of these represents a solid solution based on Bi3NbO7 (δ-phase) and the second one is a solid solution based on δ-Bi2O3 (δ′-phase). Conductivity of sintered samples is studied using the impedance spectroscopy technique. Introduction of yttrium into the bismuth sublattice results in no increase in conductivity of solid solutions, while in the case of the ratio of Bi: Nb = 3: 1, overall conductivity of solid solutions is somewhat higher at similar dopant concentrations. © 2013 Pleiades Publishing, Ltd

Assessment of genetic diversity of some Siberian and Far Eastern species of the genus Spiraea (Rosaceae) by newly developed multiplex panels of nuclear SSR loci

Taxonomic and population genetic studies of the genus Spiraea (Rosaceae) species require new informative genetic markers. We screened 37 previously published heterologous oligonucleotide primer pairs for nuclear microsatellite loci and selected eight polymorphic and most reproducible of them for PCR multiplexing which substantially increases performance of routine mass genotyping. Three multiplex sets of 3, 3 and 2 loci, respectively, were developed and tested for ability to estimate the parameters of genetic variability and  population  structure in closely related species Spiraea ussuriensis, S. f lexuosa, S. chamaedryfolia representing seven natural populations of the Russian Far East and Siberia. Allele number ranged among loci from twelve (Spth20) to three. Among 41 alleles found, 7 were unique in some species/populations. Analysis of parameters of genetic variability in Spiraea spp. showed similar values of allele number per locus and observed heterozygosity among populations and slightly greater estimates of expected hete rozygosity in the samples of S. f lexuosa (NA = 2.387; HO = 0.387 ± ± 0.052; HE = 0.540 ± 0.055) as compared to S. ussuriensis (NA = = 2.781; HO = 0.385 ± 0.079; HE = 0.453 ± 0.072) and S. chamaedryfolia (NA = 2.875; HO = 0.331 ± 0.071; HE = 0.505 ± 0.069). The observed values of genetic polymorphism parameters indicate the average level of genetic diversity of the studied species typical to previous studies in Spiraea. About 19 % of the observed variability occurred among populations (FST = 0.191) while 81 % of the total genetic variation concentrated within the populations. The loci VS11, VS12, VS2, and VS6 contributed most to the observed differentiation. Nei genetic distances  between populations ranged from 0.049 to 0.585. Genetic differentiation patterns among studied populations based on allele frequencies of nuclear microsatellite loci correspond with their geographical location. Genetic composition of some samples contradicted with their provisional species identification

ASSESSMENT OF CEREBRAL PERFUSION IN PATIENTS WITH HEMODYNAMIC ISCHEMIC STROKE UNDERGOING RECONSTRUCTIVE BRACHIOCEPHALIC ARTERY INTERVENTIONS

The paper deals with the assessment of cerebral perfusion in patients in the acute period of acute cerebrovascular accident before and after revascularization surgery. It gives a clinical example of using contrast-free perfusion magnetic resonance imaging (MRI) in a patient with hemodynamic ischemic stroke. The use of this technique made it possible to determine indications for early carotid endarterectomy for the contralateral internal carotid artery and to evaluate positive postoperative changes in cerebral perfusion and the patient’s neurological status. The authors analyzed the current literature on this problem with a particular emphasis on the possibilities of using dynamic susceptibility contrast-enhanced and arterial spin-labeling contrast-free perfusion MRI in this category of patients. Carotid endarterectomy in the acute period of acute cerebrovascular accident can improve cerebral hemodynamics and the patient’s neurological status and prevent recurrent cerebral circulatory disorders. Indications for this surgery should be determined by taking into consideration the results of perfusion MRI techniques (single-photon computed tomography contrastenhanced and contrast-free perfusion MRI)

Role of parathyroid hormone-related protein in breast cancer detection and prognosis

Currently, there are limited data supporting the use of parathyroid hormone-related protein for the purposes of breast cancer detection and disease prognosis. This literature review covers research results on diagnostic potential of parathyroid hormone-related protein as a biomarker for breast cancer, as well as the information available in the scientific literature, reflecting obvious contradictions regarding clinical and prognostic importance of this protein in the primary breast cancer, correlation of its expression with the risk of bone metastasis and survival of patients. Results of preclinical and clinical research show, that parathyroid hormone-related protein inhibits tumor progression and decreases its metastasis at early stages of the disease, which improves the survival rate, but it has an opposite effect at the advanced stages of cancer, as it increases tumor development and metastasis, and reduces survival rates. Altogether, these studies prove an idea that parathyroid hormone-related protein plays a double role in breast cancer. Use of parathyroid hormone-related protein for breast cancer early detection and disease prognosis is currently becoming a subject of detailed scientific research studies, which is confirmed by the facts presented in this literature review

Релаксационные и физико-механические характеристики полиэтиленов с различной молекулярной массой

Objectives. Determination of the influence of molecular weight on the modulus of elasticity, yield, strength, and retardation processes in polyethylene.Methods. We used vane samples (thickness: 4 mm; length: 100 mm; width.: 10 mm) made by injection molding at p = 60 MPa, T = 210 °C, τ = 15 s from the following polyethylenes: HDPE 27773 (Stavrolen, Lukoil, Russia); BorSafe HE3490-IM (Borealis, Austria; black); CRP 100 Hostalen (Basell Polyolefins, Netherlands; black); Stavrolen PE4PP-25B (Stavrolen, Lukoil, Russia; black). The samples were in accordance with the defined standards for the AL 7000 LA-5 tensile testing machine. The study of relaxation characteristics was carried out in two modes: relaxation and retardation.Results. We obtained stress-strain diagrams at various temperatures under isothermal conditions (T = const) and determined the influence of polyethylene molecular weights on the modulus of elasticity, yield, and strength of polyethylenes. We have shown that under isothermal conditions, when the stress equals the yield strength, the removal of the external action results in a two-stage response. The first stage is the stress relaxation. The second stage characterizes the elastic features of the studied materials under the external action ε = const.Conclusions. We have established that temperature increase affects the physicomechanical characteristics of polyethylenes differently, depending on their molecular weights. The experiments have shown that when the stress exceeds the yield strength, at constant deformation, there is a complex response of the polyethylenes to external action. This response is characterized by two stress stages throughout the course of time. The first stage is characterized by asymptotic decrease in stress down to a constant value; the second stage is characterized by constant stress throughout the course of time. We have determined relaxation times for the relaxation stage (stage I) and calculated activation energy. We have also established that the activation energy depends on molecular weights of the polyethylenes. It has been shown that an increase in polyethylene molecular weight leads to a decrease in relaxation time and activation energy.Цель. Определение влияния молекулярной массы полиэтиленов на модуль упругости, текучесть, прочность и процессы ретардации.Методы. В качестве образцов были взяты лопатки (толщиной 4 мм, длиной 100 мм, шириной 10 мм), полученные м.етодом литья под давлением p = 60 МПа при T = 210 °C, τ= 15 с, из полиэтилена следующих марок: ПЭВП 277-73 (Ставролен, Лукойл, Россия); BorSafe HE3490-IM (Borealis, Австрия; черный); CRP 100 Hostalen (Basell Polyolefins, Нидерланды; черный); Stavrolen PE4PP-25B (Ставролен, Лукойл, Россия; черный). Использованные образцы соответствовали стандартно-определенным образцам для исследования на разрывной лъашине AL 7000 LA-5. Исследование релаксационных характеристик проводилось в двух режимах: релаксационном и ретардационном.Результаты. В результате проведения экспериментов были получены диаграммы «напря-жение-деформация» при различных температурах в изотермических режимах (Т = const) и определено влияние молекулярной массы на модуль упругости, текучесть и прочность полиэтиленов. Показано, что при напряжениях, равных пределу текучести, в изотермических условиях при снятии внешнего деформирующего воздействия наблюдаются две стадии отклика системы полиэтилена на это воздействие. Первый отклик - процесс релаксации напряжения и второй отклик - область, характеризующая упругие характеристики исследуем.ого материала при внешнем воздействии ε = const.Заключение. Установлено, что повышение температуры неодинаково отражается на физико-механических характеристиках полиэтиленов различной молекулярной массы. Эксперименты показали, что при напряжениях выше предела текучести при постоянстве деформации наблюдается сложная реакция исследуемых полиэтиленов на внешнее воздействие. Эта реакция характеризуется двумя областями зависимости напряжений, возникших при деформации, от времени. Первая область характеризуется асимптотическим снижением напряжения до постоянного значения, а вторая область - постоянством напряжения во времени. Рассчитаны времена релаксации для релаксационной области (участок I), а также рассчитана величина энергии активации. Показано, что увеличение молекулярной массы полиэтиленов ведет к снижению времени релаксации и уменьшению энергии активации

The Flow Cytometry Study of Cellular Immunity in Rhesus Monkeys after Experimental Infection with SARS CoV 2 Virus

Cellular immunity plays an important role in the pathogenesis and formation of protective immune defense against the SARS‑CoV‑2 virus.The aim of the work was to study the cellular immunity of rhesus monkeys applying flow cytometry after experimental infection with the SARS‑CoV‑2 virus.Materials and methods. Male rhesus monkeys were intranasally inoculated with the SARS‑CoV‑2 virus, Isolate B strain and hCoV-19/Russia/SP48-1226/2020 strain (abbreviated name U-2), at a dose of 5.0 lg PFU. Using flow cytometry, the levels of 21 populations/subpopulations of mononuclear cells in the peripheral blood of animals were determined before experimental infection with the pathogen and on day 14 after infection. SARS‑CoV‑2 coronavirus RNA was assessed using real-time polymerase chain reaction. Determination of the titer of virus-neutralizing antibodies to the SARS‑CoV‑2 virus in the blood sera of animals was conducted through neutralization test evaluating the ability to suppress negative colonies.Results and discussion. Infection with Isolate B strain culture has led to an increase in the relative content of total T-lymphocytes (p˂0.2), cytotoxic T-lymphocytes (p˂0.1), as well as monocytes expressing the early activation marker CD25 (p˂0.2). The decrease in levels has been observed for total B-lymphocytes (p˂0.2) and T-helper cells (p˂0.1). Infection with the U-2 strain culture revealed an increase in the relative content of monocytes expressing the early activation marker CD25 (p˂0.2). Thus, for the first time in the Russian Federation, flow cytometry was used to study the cellular immunity of rhesus monkeys before and after experimental infection with the SARS‑CoV‑2 virus. The obtained information can be used for studying the pathogenesis of SARS‑CoV‑2 infection, course, and outcome of the disease, and developing strategies for vaccination and treatment

ДИАГНОСТИКА ВЕНОЗНОГО ИШЕМИЧЕСКОГО ИНСУЛЬТА. ЧАСТЬ I (КЛИНИЧЕСКИЙ ПОЛИМОРФИЗМ). ОБЗОР

Venous stroke being “relatively unknown cerebrovascular disease” occurs in 0.55% of all strokes. Specific diagnostic concerns to venous stroke and the expansion of the volume of radiologic examinations from routinely used non-contrast CT to angiographic and perfusion CT- and MRI, diffusion MRI allowed us to increase the number of diagnosed and verified venous ischemic stroke from 0.4% of all strokes treated in our center to 2.4%, resulting in a 6-fold increase within the 5-year period. Symptoms of cerebral venous sinus thrombosis depend on the size and the growth rate of thrombus. In addition, focal neurological symptoms are diverse and largely dependent on thrombus localization and safety of collateral blood flow, as well as patients’ age and severity of cerebral edema. Cerebral symptoms are nonspecific and may occur in varying degrees of severity related to the localization of the pathological process. The routinely used assessment scales such as the National Institutes of Health Stroke Scale (NIHSS), Bartel Index, Rankin Scale do not reliably identify this type of acute ischemic stroke. The leading symptom is headache with the mean visual analogue scale of 7.3±1.6. The tendency towards a less pronounced neurologic deficit at admission and mild disability status at discharge have been found among patients with venous stroke. The clinical course of venous stroke mostly demonstrated a tendency towards rapid regression of focal symptomatology and neurological deficit in comparison with arterial ischemic stroke.Венозный инсульт, являясь «относительно неизвестным цереброваскулярным заболеванием», встречается от 0,5% до 5% от всех случаев инсульта. Определенная «настороженность» в отношении венозного инсульта, а также расширение объема лучевых методов исследования от обязательной бесконтрастной компьютерной томографии (КТ) до выполнения ангиографических и перфузионных КТ- и МР-методик, диффузионной магнитно-резонансной томографии (МРТ) позволили на нашем опыте поднять количество диагностированного и верифицированного венозного ишемического инсульта с 0,4% от общего количества пролеченных с инсультом пациентов до 2,4%, то есть в 6 раз за 5 лет целенаправленного изучения этой патологии. При поражении синусов общемозговые симптомы зависят от массивности и скорости нарастания тромбоза, а очаговая неврологическая симптоматика многообразна и во многом определяется локализацией тромбоза и сохранностью коллатерального кровотока, а также возрастом пациента и степенью прогрессирования отёка головного мозга. Общемозговая симптоматика неспецифична и может встречаться в той или иной степени выраженности при любой локализации патологического процесса. Применение оценочных шкал, таких как National Institutes of Health Stroke Scale (NIHSS), Bartel, Rankin не позволило достоверно определить венозный характер острого ишемического инсульта. Ведущим симптомом явилась головная боль со значением по визуально-аналоговой шкале равным в среднем 7,3±1,6. Просматривалась тенденция к менее выраженному неврологическому дефициту при поступлении и более легкой степени инвалидизации при выписке в результате венозного инсульта. В клиническом течении венозного инсульта отмечается тенденция к быстрому регрессу очаговой симптоматики и неврологического дефицита в большинстве случаев, в отличие от артериального ишемического инсульта

ДИАГНОСТИКА ВЕНОЗНОГО ИШЕМИЧЕСКОГО ИНСУЛЬТА. ЧАСТЬ II (АЛГОРИТМЫ И СЕМИОТИКА ЛУЧЕВОЙ ДИАГНОСТИКИ. ОГРАНИЧЕНИЯ ИСПОЛЬЗОВАНИЯ В КЛИНИЧЕСКОЙ ПРАКТИКЕ). ОБЗОР

Venous stroke in cerebral venous sinus thrombosis is a rare pathological condition with uncertain diagnostic algorithm to ensure prompt treatment by neurologists and radiologists. All the methods are not obligatory in the workup of acute stroke, except computed tomography (CT) and transcranial Doppler. Researchers and clinicians are commonly guided by their own experiences. Therefore, the diagnosis of venous stroke is an unstable process resulting in its underestimation in the general stroke population. The optimal use of neuroimaging methods within the existing standards of care for patients with stroke, determination of the necessary and sufficient set of diagnostic procedures is an organizational and methodical problem. In addition, there is no complete description of venous ischemic stroke patterns in the medical literature. The article reviews existing evidence-based data on the diagnostic algorithms for venous stroke and discusses the probability of detecting radiologic symptoms based on the diagnostic accuracy and effectiveness of such methods as conventional CT and magnetic resonance imaging (MRI), CT and MR angiography, CT and MR perfusion, transcranial Doppler (TCD) and ultrasound of the brachiocephalic arteries stated in the national and international guidelines, as well as our own experience. Limitations of their use and options to overcome major drawbacks including the introduction of teleradiology are considered.Из-за редкости патологии инструментальная диагностика венозного инсульта при церебральном венозном синустромбозе не представляет собой хорошо отлаженный алгоритм неотложных действий команды неврологов и рентгенологов. Все применяемые методики, кроме компьютерной томографии (КТ) и ультразвуковой транскраниальной допплерографии, не являются обязательными в острый период инсульта и используются исследователями и клиницистами, как правило, интуитивно, в зависимости от уровня знакомства с данной патологией. Такой подход не делает диагностику венозного инсульта стабильным процессом и ведет к недооценке частоты этой патологии в общей статистике инсульта. Оптимальное использование методик нейровизуализации в рамках существующих стандартов помощи больным с инсультом, определение необходимого и достаточного набора диагностических процедур является в современных условиях организационно-методической проблемой, связанной с недостаточной освещенностью в литературе особенностей венозного ишемического инсульта. В статье представляются литературные данные по формированию алгоритмов диагностических мероприятий и вероятность обнаружения лучевых симптомов венозного инсульта на основании диагностической точности и эффективности таких методов как конвенциальная КТ и магнитно-резонансная томография (МРТ), КТи МР-ангиография, КТи МР-перфузия, ультразвуковая транскраниальная допплерография (ТКДГ) и сканирование брахиоцефальных сосудов (УЗДС) в рамках актуальных российских и зарубежных регламентирующих документов, а также нашего собственного опыта. Рассмотрены возможные ограничения применения этих методов и пути их преодоления, в том числе с использованием телерадиологии