383 research outputs found
Role of Inflammation in the Pathogenesis of Diabetic Nephropathy
Diabetic nephropathy is the major microvascular complication of diabetes mellitus and remains the leading cause of increased morbidity and mortality for diabetic patients. Recent evidence suggests that chronic subclinical inflammation is a key pathogenetic mechanism of the disease. Pro-inflammatory cytokines and particularly tumor necrosis factor and its
receptors appear to play a major role in the process and are emerging novel biomarkers of the development and progression of diabetic nephopathy. Moreover, manipulation of the TNF superfamily system will hopefully provide a new therapeutic option for the disease
Using Semantic Web Technologies to Query and Manage Information within Federated Cyber-Infrastructures
Using Semantic Web Technologies to Query and Manage Information within Federated Cyber-Infrastructures
The Open-Multinet Upper Ontology:Towards the Semantic-based Management of Federated Infrastructures
Women Filmmakers in the United Arab Emirates
This entry provides an introduction to the work of and the challenges faced by women filmmakers in the United Arab Emirates while at the same time providing an overview of the emerging film industry in the country. The fact that these women claim the power of representation and start telling their stories against the backdrop of a conservative, patriarchal society, obviously opens up space for gender redefinition. Overall, it seems that their films reveal a preference for strong, interesting women that fight for a meaningful life against the backdrop of a globalized society that has left women weaker and more fragile, with less obvious choices and possibilities for fulfillment. As their female characters claim center stage, both traditional and contemporary constructions of gender are called into question and popular stereotypes about Emirati women are challenged
Slice Isolation for 5G Transport Networks
Network slicing plays a key role in the 5G ecosystem for vertical industries to introduce new services. However, one widely-recognized challenge of network slicing is to provide traffic isolation and concurrently satisfy diverse performance requirements, e.g., bandwidth and latency. In this work, we showcase the capability to retain these two goals at the same time, via extending the 5Growth baseline architecture and designing a new data-plane pipeline, i.e., virtual queue, over the P4 switch. To demonstrate the effectiveness of our approach, a proof-of-concept is presented serving different service requests over a mixed data path, including P4 switches and Open vSwitches (OvSs)
Case Report Calciphylaxis: Temporal Artery Calcification Preceding Widespread Skin Lesions and Penile Necrosis
Temporal artery calciphylaxis has rarely been described in chronic kidney disease patients on dialysis. We report a case of 72-year-old Caucasian man with multiple comorbidities and end-stage renal disease on dialysis who presented with temporal artery calcification leading to bilateral loss of vision followed by extensive skin lesions including one on glans penis. While on peritoneal dialysis, he developed anterior ischemic optic neuropathy, had no improvement on high dose steroids, and temporal artery biopsy showed marked calcification without any evidence of vasculitis. Few weeks later on hemodialysis, he developed widespread cutaneous lesions on extremities and penile necrosis with skin biopsy revealing calciphylaxis. On literature review of calciphylaxis in chronic kidney disease, we found only four cases of temporal artery calciphylaxis leading to anterior ischemic optic neuropathy and blindness. We believe this is the first case in which the rare temporal artery calciphylaxis and the uncommon penile necrosis are being described together. The objective is to emphasize the need to recognize this condition early in the CKD patients on dialysis presenting with visual symptoms as the different treatment strategies may help prevent complete loss of vision and also modify or prevent a full blown calciphylaxis
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