Energy deposited by neutrons and gamma rays in the cryogenic system of SISSI

International audienc

Pathophysiology of paraneoplastic and autoimmune encephalitis: genes, infections, and checkpoint inhibitors

Paraneoplastic neurological syndromes (PNSs) are rare complications of systemic cancers that can affect all parts of the central and/or peripheral nervous system. A body of experimental and clinical data has demonstrated that the pathogenesis of PNSs is immune-mediated. Nevertheless, the mechanisms leading to immune tolerance breakdown in these conditions remain to be elucidated. Despite their rarity, PNSs offer a unique perspective to understand the complex interplay between cancer immunity, effect of immune checkpoint inhibitors (ICIs), and mechanisms underlying the attack of neurons in antibody-mediated neurological disorders, with potentially relevant therapeutic implications. In particular, it is reported that ICI treatment can unleash PNSs and that the immunopathological features of PNS-related tumors are distinctive, showing prominent tumor-infiltrating lymphocytes and germinal center reactions. Intriguingly, similar pathological substrates have gained further attention as potential biomarkers of ICI-sensitivity and oncological prognosis. Moreover, the genetic analysis of PNS-associated tumors has revealed specific molecular signatures and mutations in genes encoding onconeural proteins, leading to the production of highly immunogenic neoantigens. Other than PNSs, autoimmune encephalitides (AEs) comprise a recently described group of disorders characterized by prominent neuropsychiatric symptoms, diverse antibody spectrum, and less tight association with cancer. Other triggering factors seem to be involved in AEs. Recent data have shed light on the importance of preceding infections (in particular, herpes simplex virus encephalitis) in inducing neurological autoimmune disorders in susceptible individuals (those with a selective deficiency in the innate immune system). In addition, in some AEs (e.g. LGI1-antibody encephalitis) an association with specific host-related factors [e.g., human leukocyte antigen (HLA)] was clearly demonstrated. We provide herein a comprehensive review of the most recent findings in the field of PNSs and AEs, with particular focus on their triggering factors and immunopathogenesis

A Comparison of Three Dry Matter Forage Production Methods Used in South Africa

A common method for determining forage production of rangelands is by clipping and weighing forage from quadrats with predetermined areas. This technique is however time consuming. Other techniques which require less time and labour include amongst others using the disk pasture meter or phytomass derived from the vegetation classification program PHYTOTAB, in conjunction with the Plant Number Scale, which is used to determine vegetation canopy cover. The phytomass determined using PHYTOTAB/Plant Number Scale and the disk pasture meter was compared to the phytomass obtained from the actual clipping and weighing of forage. Tests showed that there were indeed statistically significant differences between the mean phytomass values of the three techniques. Considerable variation was shown in the results of the disk pasture meter readings compared to the other two techniques. The phytomass values obtained using the disk pasture meter were significantly higher than the phytomass determined using both the PHYTOTAB/Plant Number Scale and the clipping and weighing techniques. Results further indicated a significant similarity in the phytomass determined using the PHYTOTAB/Plant Number Scale and the clipping and weighing technique. The results of this pilot study need further investigation

A systematic approach for performance assessment using process mining. An industrial experience report

Software performance engineering is a mature field that offers methods to assess system performance. Process mining is a promising research field applied to gain insight on system processes. The interplay of these two fields opens promising applications in the industry. In this work, we report our experience applying a methodology, based on process mining techniques, for the performance assessment of a commercial data-intensive software application. The methodology has successfully assessed the scalability of future versions of this system. Moreover, it has identified bottlenecks components and replication needs for fulfilling business rules. The system, an integrated port operations management system, has been developed by Prodevelop, a medium-sized software enterprise with high expertise in geospatial technologies. The performance assessment has been carried out by a team composed by practitioners and researchers. Finally, the paper offers a deep discussion on the lessons learned during the experience, that will be useful for practitioners to adopt the methodology and for researcher to find new routes

Role of LGI1 protein in synaptic transmission: From physiology to pathology

Leucine-Rich Glioma Inactivated protein 1 (LGI1) is a secreted neuronal protein highly expressed in the central nervous system and high amount are found in the hippocampus. An alteration of its function has been described in few families of patients with autosomal dominant temporal lobe epilepsy (ADLTE) or with autoimmune limbic encephalitis (LE), both characterized by epileptic seizures. Studies have shown that LGI1 plays an essential role during development, but also in neuronal excitability through an action on voltage-gated potassium Kv1.1 channels, and in synaptic transmission by regulating the surface expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-R). Over the last decade, a growing number of studies investigating LGI1 functions have been published. They aimed to improve the understanding of LGI1 function in the regulation of neuronal networks using different animal and cellular models. LGI1 appears to be a major actor of synaptic regulation by modulating trans-synaptically pre- and post-synaptic proteins. In this review, we will focus on LGI1 binding partners, “A Disintegrin And Metalloprotease (ADAM) 22 and 23”, the complex they form at the synapse, and will discuss the effects of LGI1 on neuronal excitability and synaptic transmission in physiological and pathological conditions. Finally, we will highlight new insights regarding N-terminal Leucine-Rich Repeat (LRR) domain and C-terminal Epitempin repeat (EPTP) domain and their potentially distinct role in LGI1 function