3,507 research outputs found
Children’s and Household Tales: from Oral Tradition to Children’s Literature
Os irmãos Grimm (Alemanha- séc.XIX) foram dos mais prolíferos escritores de histórias de potencial receção Infanto-juvenil, tornando imortais contos como: “Capuchinho Vermelho”, “A cabra e os sete cabritinhos”, “A bela Adormecida” ou “Gata Borralheira”, entre outros, que continuam no século XXI a despertar sonho e magia nas mentes infantis.
No nosso artigo, trataremos de refletir sobre a originalidade e importância da sua obra literária: Contos da infância e do lar, revisitando os aspetos mais importantes e significativos nela enunciados. Para isso, seguimos uma metodologia analítica, baseada nos textos originais dos Grimm, bem como em especialistas atualizados nesta matéria
Selection of imprinted nanoparticles by affinity chromatography
Soluble molecularly imprinted nanoparticles were synthesised via iniferter
initiated polymerisation and separated by size via gel permeation
chromatography. Subsequent fractionation of these particles by affinity
chromatography allowed the separation of high affinity fractions from the
mixture of nanoparticles. Fractions selected this way possess affinity similar
to that of natural antibodies (Kd 6.6 × 10−8) M and were also able to
discriminate between related functional analogues of the templ
Predisposition To Metabolic Acidosis Induced By Topiramate.
Metabolic acidosis induced by topiramate is a well documented but infrequent adverse event. The objective was to demonstrate the lowering of carbon dioxide serum levels, which is usually asymptomatic but may facilitate the occurrence of metabolic acidosis in patients using topiramate. We evaluated, prospectively, the carbon dioxide serum levels of 18 patients seen at the epilepsy clinic of our university hospital, before and 3 months after introducing topiramate. Five patients were female and 13 were male, age ranging from 2 to 16 years old (mean=9. 3). Carbon dioxide mean serum levels were 25 and 21.2 mmol/L (normal = 22 to 30), before and 3 months after introducing topiramate, respectively. Dose ranged from 2.08 to 11.76 mg/kg/day (mean=6. 7mg/kg/day). Adverse events were anorexia, nausea and somnolence. We conclude that the lowering of carbon dioxide serum levels induced by topiramate is mostly asymptomatic, but may facilitate the occurrence of metabolic acidosis. Since patients in use of topiramate have refractory epilepsy, they may need epilepsy surgery, and must be carefully monitored for the risk of metabolic acidosis during surgery.581021-
High efficiency coupling of photon pairs in practice
Multi-photon and quantum communication experiments such as loophole-free Bell
tests and device independent quantum key distribution require entangled photon
sources which display high coupling efficiency. In this paper we put forward a
simple quantum theoretical model which allows the experimenter to design a
source with high pair coupling efficiency. In particular we apply this approach
to a situation where high coupling has not been previously obtained: we
demonstrate a symmetric coupling efficiency of more than 80% in a highly
frequency non-degenerate configuration. Furthermore, we demonstrate this
technique in a broad range of configurations, i.e. in continuous wave and
pulsed pump regimes, and for different nonlinear crystals
Ulcerative colitis: let's talk about extent
Ulcerative colitis (UC) is a chronic inflammatory disease in which clinical course varies substantially between patients.
The extent of the disease is usually pointed out as one of the factors
responsible for this variation. With this study, we pretended to evaluate the differences in natural history and pharmacological therapy
prescription between left-sided and extended UC
The stabilisation of receptor structure in low cross-linked MIPs by an immobilised template
In molecularly imprinted polymers (MIPs) a high level of cross-linking is
usually important for preserving the receptor structure. We propose here an
alternative approach for stabilising binding sites, which involves the use of an
immobilised template. The idea is based on the assumption that an immobilised
template will ‘‘hold’’ polymeric chains and complementary functionalities
together, preventing the collapsing of the binding sites. To test this
postulate, a range of polymers was prepared using polymerisable (2,4-diamino-6-
(methacryloyloxy)ethyl-1,3,5-triazine) and non-polymerisable (or extractable)
(2,4-diamino-6-methyl-1,3,5-triazine) templates, methacrylic acid as functional
monomer and ethylene glycol dimethacrylate as cross-linker. The level of cross-
linking was varied from 12 to 80%. Polymerisations were performed in
acetonitrile using UV initiation. Binding properties of the synthesised
materials were characterised both by HPLC and equilibrium batch binding
experiments followed by HPLC-MS or UV-visible detection. The adsorption
isotherms of polymers were obtained and fitted to the Langmuir model to
calculate dissociation constant, Kd, and concentration of binding sites for each
material. The results strongly indicate that the presence of an immobilised
template improves the affinity of MIPs containing low percentages of cross-
linker. The low cross-linked MIPs synthesised with a polymerisable template also
retain a reasonable degree of selectivity. Low crosslinked MIPs with such
binding characteristics would be useful for the creation of new types of optical
and electrochemical sensors, where induced fit or the ‘‘gate effect’’ could be
used more effectively for generating and enhancin
First, Do No Harm: The Risks Of Overtreating Children With Epilepsy
Background: Although overtreatment with antiepileptic drugs contributes to the morbidity associated with epilepsy, many children still are overtreated. Objective: To evaluate if the withdrawal of at least one antiepileptic drug (AED) in children with refractory epilepsy using polytherapy enable a better seizure control. Method: This was a prospective study. Children with refractory epilepsy using at least two AEDs were included. Once the patient, or guardian, agreed to participate in the study, one or more AED were slowly tapered off. The remaining AEDs dosages could be adjusted as needed, but a new AED could not be introduced. Results: Fifteen patients were evaluated, three girls; ages ranging from 3 to 18 (mean=8.7 years). After at least one AED withdrawal, two (13.5%) patients became seizure free, seizures improved >50% in 5 (33.5%) patients, did not change in 5 (33.5%), and seizure frequency became worse in 3 (20%). Adverse events improved in 12 patients (80%). Conclusion: The withdrawal of at least one AED is a valuable option in the treatment of selected children with refractory epilepsy.65114Camfield, C.S., Camfield, P., Gordon, K., Smith, B., Dooley, J., Outcome of childhood epilepsy: A population-based study with a simple scoring system for those treated with medication (1993) J Pediatr, 122, pp. 861-868Silva, M., MacArdle, B., MaGowan, M., Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy (1996) Lancet, 347, pp. 709-713Baulac, M., Rational conversion from antiepileptic polytherapy to monotherapy (2003) Epileptic Disord, 5, pp. 125-132Holmes, G.L., Overtreatment in children with epilepsy (2002) Epilepsy Res, 52, pp. 35-42Fischbacher, E., Effect of reduction of anticonvulsants on wellbeing (1982) Br Med J (Clin Res Ed), 285, pp. 423-424Schmidt, D., Reduction of two-drug therapy in intractable epilepsy (1983) Epilepsia, 24, pp. 368-376Alvarez, N., Discontinuance of antiepileptic medications in patients with developmental disability and diagnosis of epilepsy (1989) Am J Ment Retard, 93, pp. 593-595Guerrini, R., Belmonte, A., Genton, P., Antiepileptic drug-induced worsening of seizures in children (1998) Epilepsia, 39 (SUPPL. 3), pp. S2-S10TS, K., Holmes, G.L., EEG and clinical predictors of medically intractable childhood epilepsy (1999) Clin Neurophysiol, 110, pp. 1245-1251Huttenlocker, P.R., Hapke, R.J., A follow-up study of intractable seizures in childhood (1990) Ann Neurol, 28, pp. 699-705Ferngren, H., Akerstrom, I., Rane, A., Mono or polypharmacotherapy in institutionalized epileptic children with severe mental retardation? A team approach for optimizing antiepileptic therapy (1991) Acta Paediatr Scand, 80, pp. 458-465Dooley, J., Gordon, K., Camfield, C., Smith, E., Discontinuation of anticonvulsant therapy in children free of seizures for 1 year: A prospective study (1996) Neurology, 46, pp. 969-974Shinnar, S., Berg, A.T., Moshé, S.L., Discontinuing antiepileptic drugs in children with epilepsy:a prospective study (1994) Ann Neurol, 35, pp. 534-545Shorvon, S.D., Reynolds, E.H., Unnecessary polypharmacy for epilepsy (1977) Br Med J, 1, pp. 1635-1637Vickery, B.G., Hay, R., Engel, J., Outcome assessment for epilepsy surgery: The impact of measuring health-related quality of life (1995) Ann Neurol, 37, pp. 158-16
The influence of foreign equity and board membership on corporate strategy and management of internal costs in Portuguese banks
This study examines the influence of foreign equity and board membership on corporate
strategy and the management of internal costs of banks headquartered in Portugal using
proprietary data maintained by the Central Bank. The findings reveal that foreign equity reduces
both total and operating costs, and foreign board membership reduces domestic banks’
dependence on revenues from traditional areas of business and enhances the potential for
generating revenues from non-traditional areas of business. These results are controlled for a
variety of standard accounting ratios used in the literature. We argue that foreign equity and
board membership forces banks to redirect corporate strategy and to reduce internal costs.info:eu-repo/semantics/acceptedVersio
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