STEMteach: Preparing the Next Generation of Mathematics and Science Teachers

With an increasing demand for individuals prepared in Science, Technology, Engineering, and Mathematics (STEM), one university responded to this call by changing its teacher preparation program. Better-prepared mathematics and science teachers have the opportunity to engage and excite students, thereby preparing and promoting more of them to enter the STEM professions. The described program is a replication of the national UTeach model that recruits content majors in mathematics and science to explore the teaching profession during a first-semester course that includes an early field experience in the elementary grades. This field experience is designed to be engaging for both the teacher education candidates and the elementary students in an effort to demonstrate the joy of teaching and to retain the candidates in the program. The ultimate goal of the program is to increase the production of quality secondary mathematics and science teachers who can transfer their own deep understanding of their content to students so that these students will be career and college ready in the STEM disciplines

The Becklin-Neugebauer Object as a Runaway B Star, Ejected 4000 years ago from the theta^1C system

We attempt to explain the properties of the Becklin-Neugebauer (BN) object as a runaway B star, as originally proposed by Plambeck et al. (1995). This is one of the best-studied bright infrared sources, located in the Orion Nebula Cluster -- an important testing ground for massive star formation theories. From radio observations of BN's proper motion, we trace its trajectory back to Trapezium star theta^1C, the most massive (45 Msun) in the cluster and a relatively tight (17 AU) visual binary with a B star secondary. This origin would be the most recent known runaway B star ejection event, occurring only \~4000 yr ago and providing a unique test of models of ejection from multiple systems of massive stars. Although highly obscured, we can constrain BN's mass (~7 Msun) from both its bolometric luminosity and the recoil of theta^1C. Interaction of a runaway B star with dense ambient gas should produce a compact wind bow shock. We suggest that X-ray emission from this shocked gas may have been seen by Chandra: the offset from the radio position is ~300 AU in the direction of BN's motion. Given this model, we constrain the ambient density, wind mass-loss rate and wind velocity. BN made closest approach to the massive protostar, source ``I'', 500 yr ago. This may have triggered enhanced accretion and thus outflow, consistent with previous interpretations of the outflow being a recent (~10^3 yr) "explosive" event.Comment: 6 pages, accepted to ApJ Letter

Power Spectra in Global Defect Theories of Cosmic Structure Formation

An efficient technique for computing perturbation power spectra in field ordering theories of cosmic structure formation is introduced, enabling computations to be carried out with unprecedented precision. Large scale simulations are used to measure unequal time correlators of the source stress energy, taking advantage of scaling during matter and radiation domination, and causality, to make optimal use of the available dynamic range. The correlators are then re-expressed in terms of a sum of eigenvector products, a representation which we argue is optimal, enabling the computation of the final power spectra to be performed at high accuracy. Microwave anisotropy and matter perturbation power spectra for global strings, monopoles, textures and non-topological textures are presented and compared with recent observations.Comment: 4 pages, compressed and uuencoded RevTex file and postscript figure

Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines.

Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines with different responses to NDV, Fayoumi and Leghorn, were challenged with LaSota NDV strain at 21 days of age. Through transcriptome analysis, gene expression in spleen at 2 and 6 days post-inoculation was compared between NDV-infected and control groups, as well as between chicken lines. At a false discovery rate <0.05, Fayoumi chickens, which are relatively more resistant to NDV, showed fewer differentially expressed genes (DEGs) than Leghorn chickens. Several interferon-stimulated genes were identified as important DEGs regulating immune response to NDV in chicken. Pathways predicted by IPA analysis, such as "EIF-signaling", "actin cytoskeleton organization nitric oxide production" and "coagulation system" may contribute to resistance to NDV in Fayoumi chickens. The identified DEGs and predicted pathways may contribute to differential responses to NDV between the two chicken lines and provide potential targets for breeding chickens that are more resistant to NDV

In Situ Label-Free Study of Protein Adsorption on Nanoparticles

[Image: see text] Improving the design of nanoparticles for use as drug carriers or biosensors requires a better understanding of the protein–nanoparticle interaction. Here, we present a new tool to investigate this interaction in situ and without additional labeling of the proteins and/or nanoparticles. By combining nonresonant second-harmonic light scattering with a modified Langmuir model, we show that it is possible to gain insight into the adsorption behavior of blood proteins, namely fibrinogen, human serum albumin, and transferrin, onto negatively charged polystyrene nanoparticles. The modified Langmuir model gives us access to the maximum amount of adsorbed protein, the apparent binding constant, and Gibbs free energy. Furthermore, we employ the method to investigate the influence of the nanoparticle size on the adsorption of human serum albumin and find that the amount of adsorbed protein increases more than the surface area per nanoparticle for larger diameters

Measuring life events and their association with clinical disorder: a protocol for development of an online approach

Background: Severe life events are acknowledged as important aetiological factors in the development of clinical disorders, including major depression. Interview methods capable of assessing context and meaning of events have demonstrated superior validity compared to checklist questionnaire methods and arguments for interview approaches have resurfaced as choice of assessment tool has been implicated in gene-environment interactions in depression. Such approaches also have greater potential for understanding and treating clinical cases or for use in interventions. Objectives: (i) To argue that life events need sophisticated measurement not satisfactorily captured in checklist approaches. (ii) To review life events measures and key findings related to disorder, exemplifying depression. (iii) To describe an ongoing study with a new online measure, to assess its psychometric properties and the association of life events in relation to disorder and educational outcomes. Methods: The Computerised Life Events Assessment Record (CLEAR) is under development as a tool for online assessment of adult life events. Based on the Life Events and Difficulties Schedule (LEDS) interview, CLEAR seeks to assess life events to self and close others, link these to other events and difficulties and utilise calendar-based timing, to improve upon checklist approaches. The phases of the study are outlined in terms of its samples of midlife cases with depression, unaffected controls and students, testing of the psychometric properties of CLEAR, as well as proposed investigations of its association with disorder and educational outcomes. Conclusions: There is currently no sophisticated technological application of social risk factor assessment, such as life events and difficulties. CLEAR is designed to gather reliable and valid life event data whilst combatting the limitations of interviews (e.g. time consuming and costly) and life event checklists (e.g. inability to accurately measure severity and independence of life events). The advantages of using such innovative methodology for research, clinical practice and interventions are discussed

Chemoprevention of lung cancer—from biology to clinical reality

Lung cancer is the commonest cause of cancer death in developed countries and throughout the world. Cigarette smoking is the main risk factor for lung cancer and ex-smokers today comprise ∼50% of all new lung cancer cases. Chemoprevention builds on the concepts of field of cancerization and multistep carcinogenesis and can be defined as the use of natural or chemical compounds to prevent, inhibit or reverse the process of carcinogenesis. So far, chemoprevention studies in lung cancer have failed to reduce lung cancer mortality. New developments in biotechnology have made it possible to define more accurately high-risk populations, make earlier diagnosis possible, and allow more specific targeted therapies to be developed. Both the development and validation of biomarkers, for the selection of high-risk study populations and for response evaluation in chemoprevention studies, are important for the faster turnover of studies evaluating new agents. This article reviews the current status and describes the perspectives for new approaches in the chemoprevention of lung cance

Detectability of Microwave Background Polarization

[NOTE: Previous versions of this paper (both on astro-ph and published in Phys. Rev. D) contain results that are in error. The power spectra C_l were normalized incorrectly by a factor of 2 pi. All observing times in detector-years in those versions are too large by a factor of 2 pi. The main place these numbers appear is on the vertical axes of Figures 4 and 5. Note that because all calculations were based on the same power spectra, all conclusions pertaining to comparisons of different techniques remain unchanged. This error has been corrected in the present version of the paper. An erratum is being sent to Phys. Rev. D. I apologize for the error.] Using a Fisher-matrix formalism, we calculate the required sensitivities and observing times for an experiment to measure the amplitudes of both E and B components as a function of sky coverage, taking full account of the fact that the two components cannot be perfectly separated in an incomplete sky map. We also present a simple approximation scheme that accounts for mixing of E and B components in computing predicted errors in the E-component power spectrum amplitude. In an experiment with small sky coverage, mixing of the two components increases the difficulty of detecting the subdominant B component by a factor of two or more in observing time; however, for larger survey sizes the effect of mixing is less pronounced. Surprisingly, mixing of E and B components can enhance the detectability of the E component by increasing the effective number of independent modes that probe this componentComment: Previous versions of this paper contained results that were in error. The present version on astro-ph has been corrected, and an erratum is being submitted. See abstract for detail

Observational constraints on the spectral index of the cosmological curvature perturbation

We evaluate the observational constraints on the spectral index $n$, in the context of the $\Lambda$CDM hypothesis which represents the simplest viable cosmology. We first take $n$ to be practically scale-independent. Ignoring reionization, we find at a nominal 2-$\sigma$ level $n\simeq 1.0 \pm 0.1$. If we make the more realisitic assumption that reionization occurs when a fraction $f\sim 10^{-5}$ to 1 of the matter has collapsed, the 2-$\sigma$ lower bound is unchanged while the 1-$\sigma$ bound rises slightly. These constraints are compared with the prediction of various inflation models. Then we investigate the two-parameter scale-dependent spectral index, predicted by running-mass inflation models, and find that present data allow significant scale-dependence of $n$, which occurs in a physically reasonable regime of parameter space.Comment: ReVTeX, 15 pages, 5 figures and 3 tables, uses epsf.sty Improved treatment of reionization and small bug fixed in the constant n case; more convenient parameterization and better treatment of the n dependence in the CMB anisotropy for the running mass case; conclusions basically unchanged; references adde