Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study

Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701–negative recipients

Flight and tunnel test results of the MDC mechanical jet noise suppressor nozzle

The flight and wind tunnel tests to determine the acoustic and performance effects of a mechanical jet noise suppressor nozzle mounted on a Viper engine of an HS-125 airplane are discussed. Flyover noise measurements were made with microphones mounted on top of a 137.5 m bridge tower. Seven nozzle configurations including two references nozzles, two suppressors, and three ejector inlets were tested. The suppressor nozzle of interest for an advanced supersonic transport, the suppressor/treated ejector, achieved a measured noise reduction of 14 EPNdB relative to a conventional conical reference nozzle at the highest pressure ratio tested (approximately 2.5). The unique engine nacelle, flight hardware, and nacelles from the HS-125 flight test program, combined with a simulated HS-125 fuselage were windtunnel tested. Both propulsion and acoustic data were recorded. Preliminary thrust data results from the wind tunnel tests are summarized and compared to other mechanical suppressor test results. The test results indicate that a noise reduction of at least 16 EPNdB would be possible for the suppressor/ejector nozzle scaled to typical AST engine size with a 5% thrust loss at a typical takeoff climb speed

On the Excess Dispersion in the Polarization Position Angle of Pulsar Radio Emission

The polarization position angles (PA) of pulsar radio emission occupy a distribution that can be much wider than what is expected from the average linear polarization and the off-pulse instrumental noise. Contrary to our limited understanding of the emission mechanism, the excess dispersion in PA implies that pulsar PAs vary in a random fashion. An eigenvalue analysis of the measured Stokes parameters is developed to determine the origin of the excess PA dispersion. The analysis is applied to sensitive, well-calibrated polarization observations of PSR B1929+10 and PSR B2020+28. The analysis clarifies the origin of polarization fluctuations in the emission and reveals that the excess PA dispersion is caused by the isotropic inflation of the data point cluster formed by the measured Stokes parameters. The inflation of the cluster is not consistent with random fluctuations in PA, as might be expected from random changes in the orientation of the magnetic field lines in the emission region or from stochastic Faraday rotation in either the pulsar magnetosphere or the interstellar medium. The inflation of the cluster, and thus the excess PA dispersion, is attributed to randomly polarized radiation in the received pulsar signal. The analysis also indicates that orthogonal polarization modes (OPM) occur where the radio emission is heavily modulated. In fact, OPM may only occur where the modulation index exceeds a critical value of about 0.3.Comment: Accepted for publication in Ap

Self-aligned fabrication process for silicon quantum computer devices

We describe a fabrication process for devices with few quantum bits (qubits), which are suitable for proof-of-principle demonstrations of silicon-based quantum computation. The devices follow the Kane proposal to use the nuclear spins of 31P donors in 28Si as qubits, controlled by metal surface gates and measured using single electron transistors (SETs). The accurate registration of 31P donors to control gates and read-out SETs is achieved through the use of a self-aligned process which incorporates electron beam patterning, ion implantation and triple-angle shadow-mask metal evaporation

Social Support Seeking And Early Adolescent Depression And Anxiety Symptoms: The Moderating Role Of Rumination

This study examined how social support seeking and rumination interacted to predict depression and anxiety symptoms 6 months later in early adolescents (N = 118; 11-14 years at baseline). We expected social support seeking would be more helpful for adolescents engaging in low rather than high levels of rumination. Adolescents self-reported on all measures at baseline, and on depression and anxiety symptoms 6 months later. Social support seeking predicted fewer symptoms of depression and anxiety at low rumination levels but was not associated with benefits as rumination increased. For depression symptoms, social support seeking predicted more symptoms at high rumination levels. Results were stronger for emotion-focused than problem-focused support seeking and for depression compared with anxiety symptoms. These findings suggest that cognitive risk factors like rumination may explain some inconsistencies in previous social support literature, and highlight the importance of a nuanced approach to studying social support seeking

Simultaneous single-pulse observations of radio pulsars: II. Orthogonal polarization modes in PSR B1133+16

In this paper, we present a study of orthogonal polarization modes in the radio emission of PSR B1133+16, conducted within the frame of simultaneous, multi-frequency, single-pulse observations. Simultaneously observing at two frequencies (1.41 GHz and 4.85 GHz) provides the means to study the bandwidth of polarization features such as the polarization position angle. We find two main results. First, that there is a high degree of correlation between the polarization modes at the two frequencies. Secondly, the modes occur more equally and the fractional linear polarization decreases towards higher frequencies. We discuss this frequency evolution and propose propagation effects in the pulsar magnetosphere as its origin.Comment: Accepted for publication in A&A. 5 pages, 4 figure

A content validity approach to creating an end-user computer skill assessment tool

Practical assessment instruments are commonly used in the workplace and educational environments to assess a person's level of digital literacy and end-user computer skill. However, it is often difficult to find statistical evidence of the actual validity of instruments being used. To ensure that the correct factors are being assessed for a particular purpose it is necessary to undertake some type of psychometric testing, and the first step is to study the content relevance of the measure. The purpose of this paper is to report on the rigorous judgment quantification process using panels of experts in order to establish inter-rater reliability and agreement in the development of end-user instruments developed to measure workplace skills using spreadsheet and word-processing applications

Are workplace end-user computing skills at a desirable level? A New Zealand perspective

End-user computing is part of many occupations. The most requested end-user computing skills are experience with word-processing and spreadsheet applications. Often an employee’s skill level may not be good enough to be deemed effective. Frequently this occurs because employers expect that employees will have the requisite skill level without formally assessing this. This paper presents a study involving the testing of people who, in their jobs, use word-processing and spreadsheet software. Two instruments were created to assess skill in common work place computing tasks. The results showed that the majority of participants could only manage very basic spreadsheet tasks, even though the use of spreadsheets was part of their employment. Results for word-processing skill was more positive, with most participants completing all of the basic and some moderately advanced tasks. These results confirm that end-user computer skill, while required, is not at a level that could be deemed proficient