Limitations of Radar Coordinates

The construction of a radar coordinate system about the world line of an observer is discussed. Radar coordinates for a hyperbolic observer as well as a uniformly rotating observer are described in detail. The utility of the notion of radar distance and the admissibility of radar coordinates are investigated. Our results provide a critical assessment of the physical significance of radar coordinates.Comment: 12 pages, revtex and pictex macros, 3 pictex figures, 1 eps figure. Expanded versio

Long-Term Multiwavelength Studies of High-Redshift Blazar 0836+710

Aims. The observation of gamma -ray flares from blazar 0836+710 in 2011, following a period of quiescence, offered an opportunity to study correlated activity at different wavelengths for a high-redshift (z=2.218) active galactic nucleus. Methods. Optical and radio monitoring, plus Fermi-LAT gamma-ray monitoring provided 2008-2012 coverage, while Swift offered auxiliary optical, ultraviolet, and X-ray information. Other contemporaneous observations were used to construct a broad-band spectral energy distribution. Results. There is evidence of correlation but not a measurable lag between the optical and gamma-ray flaring emission. On the contrary, there is no clear correlation between radio and gamma-ray activity, indicating radio emission regions that are unrelated to the parts of the jet that produce the gamma-rays. The gamma-ray energy spectrum is unusual in showing a change of shape from a power law to a curved spectrum when going from the quiescent state to the active state.Comment: 11 pages, 10 figures, Accepted for publication in A&

Preferential attachment in the growth of social networks: the case of Wikipedia

We present an analysis of the statistical properties and growth of the free on-line encyclopedia Wikipedia. By describing topics by vertices and hyperlinks between them as edges, we can represent this encyclopedia as a directed graph. The topological properties of this graph are in close analogy with that of the World Wide Web, despite the very different growth mechanism. In particular we measure a scale--invariant distribution of the in-- and out-- degree and we are able to reproduce these features by means of a simple statistical model. As a major consequence, Wikipedia growth can be described by local rules such as the preferential attachment mechanism, though users can act globally on the network.Comment: 4 pages, 4 figures, revte

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a major clinical feature of cachexia, leading to weight loss, dampening patients' quality of life, and reducing patients' response to anticancer therapy. RAGE (receptor for advanced glycation end-products) is a multiligand receptor of the immunoglobulin superfamily and a mediator of muscle regeneration, inflammation, and cancer. Methods: By using murine models consisting in the injection of colon 26 murine adenocarcinoma (C26-ADK) or Lewis lung carcinoma (LLC) cells in BALB/c and C57BL/6 or Ager−/− (RAGE-null) mice, respectively, we investigated the involvement of RAGE signalling in the main features of cancer cachexia, including the inflammatory state. In vitro experiments were performed using myotubes derived from C2C12 myoblasts or primary myoblasts isolated from C57BL/6 wild type and Ager−/− mice treated with the RAGE ligand, S100B (S100 calcium-binding protein B), TNF (tumor necrosis factor)α±IFN (interferon) γ, and tumour cell- or masses-conditioned media to analyse hallmarks of muscle atrophy. Finally, muscles of wild type and Ager−/− mice were injected with TNFα/IFNγ or S100B in a tumour-free environment. Results: We demonstrate that RAGE is determinant to activate signalling pathways leading to muscle protein degradation in the presence of proinflammatory cytokines and/or tumour-derived cachexia-inducing factors. We identify the RAGE ligand, S100B, as a novel factor able to induce muscle atrophy per se via a p38 MAPK (p38 mitogen-activated protein kinase)/myogenin axis and STAT3 (signal transducer and activator of transcription 3)-dependent MyoD (myoblast determination protein 1) degradation. Lastly, we found that in cancer conditions, an increase in serum levels of tumour-derived S100B and HMGB1 (high mobility group box 1) occurs leading to chronic activation/overexpression of RAGE, which induces hallmarks of cancer cachexia (i.e. muscle wasting, systemic inflammation, and release of tumour-derived pro-cachectic factors). Absence of RAGE in mice translates into reduced serum levels of cachexia-inducing factors, delayed loss of muscle mass and strength, reduced tumour progression, and increased survival. Conclusions: RAGE is a molecular determinant in inducing the hallmarks of cancer cachexia, and molecular targeting of RAGE might represent a therapeutic strategy to prevent or counteract the cachectic syndrome

Conservative upper limits on WIMP annihilation cross section from Fermi-LAT γ\gamma-rays

The spectrum of an isotropic extragalactic $\gamma$-ray background (EGB) has been measured by the Fermi-LAT telescope at high latitudes. Two new models for the EGB are derived from the subtraction of unresolved point sources and extragalactic diffuse processes, which could explain from 30% to 70% of the Fermi-LAT EGB. Within the hypothesis that the two residual EGBs are entirely due to the annihilation of dark matter (DM) particles in the Galactic halo, we obtain $conservative$ upper limits on their annihilation cross section \sigmav. Severe bounds on a possible Sommerfeld enhancement of the annihilation cross section are set as well. Finally, would {\sigmav} be inversely proportional to the WIMP velocity, very severe limits are derived for the velocity-independent part of the annihilation cross section.Comment: Proceedings of XII Taup Conference, Munich, September 201

The ducky^{2J} Mutation in Cacna2d2 Results in Reduced Spontaneous Purkinje Cell Activity and Altered Gene Expression

The mouse mutant ducky and its allele ducky^{2J} represent a model for absence epilepsy characterized by spike-wave seizures and cerebellar ataxia. These mice have mutations in Cacna2d2, which encodes the α₂δ-2 calcium channel subunit. Of relevance to the ataxic phenotype, α₂δ-2 mRNA is strongly expressed in cerebellar Purkinje cells (PCs). The Cacna2d2du2J mutation results in a 2 bp deletion in the coding region and a complete loss of α₂δ-2 protein. Here we show that du^{2J}/du^{2J} mice have a 30% reduction in somatic calcium current and a marked fall in the spontaneous PC firing rate at 22°C, accompanied by a decrease in firing regularity, which is not affected by blocking synaptic input to PCs. At 34°C, du^{2J}/du^{2J} PCs show no spontaneous intrinsic activity. DU^{2J}/du^{2J} mice also have alterations in the cerebellar expression of several genes related to PC function. At postnatal day 21, there is an elevation of tyrosine hydroxylase mRNA and a reduction in tenascin-C gene expression. Although du^{2J}/+ mice have a marked reduction in α₂δ-2 protein, they show no fall in PC somatic calcium currents or increase in cerebellar tryrosine hydroxylase gene expression. However, du^{2J}/+ PCs do exhibit a significant reduction in firing rate, correlating with the reduction in α₂δ-2. A hypothesis for future study is that effects on gene expression occur as a result of a reduction in somatic calcium currents, whereas effects on PC firing occur as a long-term result of loss of α₂δ-2 and/or a reduction in calcium currents and calcium-dependent processes in regions other than the soma

PROCEDURAL MODELLING FOR HBIM OF ITALIAN RAILWAYS IRON BRIDGES

Abstract. The development of the railways network in the 19th century represented a significant scenario for the technological advancement of the entire Italian building sector; consequently, it produced a relevant renewal of construction techniques. Icons of this robust infrastructure building program were the railway bridges built over the Po river; their construction represented an arduous technological challenge. Unfortunately, in the years following the proclamation of the Kingdom of Italy the national industry was disorganized and unprepared to face this ambitious challenge; indeed, the first four bridges were built by foreign companies that could guarantee the necessary technological know-how. However, the industrial scenario immediately changed and the last two bridges were designed and built by Italian engineers and steelwork companies. The railway bridges over the River Po are now lost; the changing needs of railway traffic or bombings during the Second World War unavoidably led to their demolition. Their enhancement through 3d modelling and virtual representation is fundamental for the rediscovering of the role they played not only in the construction of the national infrastructural system but also in the life of the young state. To this aim, the paper proposes the outcomes of research that explores the potentialities of 3d software with Visual Programming Language (VPL), in order to create modelling tools useful for the disclosure and dissemination of the historical value of this lost heritage

THE LOST HERITAGE OF ROMAN IRON AND STEEL BRIDGES. VIRTUAL RECONSTRUCTION OF TWO CASE STUDIES

Abstract. In the second half of 19th century the city of Rome knew a period of great urban transformations: the Pope Pio IX and after, the government of the new Kingdom of Italy, strongly pushed the modernization of the ancient and underdeveloped city, trying to follow the examples of the main European capitals. One of the most relevant signs of that period was the construction of multiple iron and steel bridges along the Tiber, that were built to improve the crossing network guaranteed by the old masonry links. Different supporting systems were used and many experimental technologies for the Italian context were tested, representing a crucial phase for the settle of a design and an industrial know-how that was firstly imported from the most advanced countries of the Northern Europe. In the 20th century most of these connections were unfortunately replaced, losing this precious heritage which was strongly linked to the technological culture of the time. Garibaldi Bridge, still present but radically transformed, and Alari Bridge, completely demolished, have been accurately modelled thanks to the availability of appropriate archival documentation and on-site tests, applied following a proposed methodology. The virtual reconstruction of the two case studies permits to spread the knowledge of this lost heritage, to ease the divulgation of past technologies and to recover the unusual image of exposed iron and steel structures surrounded by the ancient panorama of the Eternal city.</p