The prevalence and nature of unrequited love

Unrequited love (UL) is unreciprocated love that causes yearning for more complete love. Five types of UL are delineated and conceptualized on a continuum from lower to greater levels of interdependence: crush on someone unavailable, crush on someone nearby, pursuing a love object, longing for a past lover, and an unequal love relationship. Study 1a found all types of UL relationships to be less emotionally intense than equal love and 4 times more frequent than equal love during a 2-year period. Study 1b found little evidence for limerent qualities of UL. Study 2 found all types of UL to be less intense than equal love on passion, sacrifice, dependency, commitment, and practical love, but more intense than equal love on turmoil. These results suggest that UL is not a good simulation of true romantic love, but an inferior approximation of that ideal

Scale-free networks as preasymptotic regimes of superlinear preferential attachment

We study the following paradox associated with networks growing according to superlinear preferential attachment: superlinear preference cannot produce scale-free networks in the thermodynamic limit, but there are superlinearly growing network models that perfectly match the structure of some real scale-free networks, such as the Internet. We obtain an analytic solution, supported by extensive simulations, for the degree distribution in superlinearly growing networks with arbitrary average degree, and confirm that in the true thermodynamic limit these networks are indeed degenerate, i.e., almost all nodes have low degrees. We then show that superlinear growth has vast preasymptotic regimes whose depths depend both on the average degree in the network and on how superlinear the preference kernel is. We demonstrate that a superlinearly growing network model can reproduce, in its preasymptotic regime, the structure of a real network, if the model captures some sufficiently strong structural constraints -- rich-club connectivity, for example. These findings suggest that real scale-free networks of finite size may exist in preasymptotic regimes of network evolution processes that lead to degenerate network formations in the thermodynamic limit

Dispersible formulation of artemether/lumefantrine: specifically developed for infants and young children

Infants and children under five years of age are the most vulnerable to malaria with over 1,700 deaths per day from malaria in this group. However, until recently, there were no WHO-endorsed paediatric anti-malarial formulations available

Spectroscopy of QUEST RR Lyrae Variables: the new Virgo Stellar Stream

Eighteen RR Lyrae variables (RRLs) that lie in the "12\fh 4 clump" identified by the QUEST survey have been observed spectroscopically to measure their radial velocities and metal abundances. Ten blue horizontal branch (BHB) stars identified by the Sloan Digital Sky Survey (SDSS) were added to this sample. Six of the 9 stars in the densest region of the clump have a mean radial velocity in the galactic rest frame ($V_{\rm gsr}$) of 99.8 and $\sigma$ = 17.3 ${\rm km s}^{-1}$, which is slightly smaller than the average error of the measurements. The whole sample contains 8 RRLs and 5 BHB stars that have values of $V_{\rm gsr}$ suggesting membership in this stream. For 7 of these RRLs, the measurements of [Fe/H], which have an internal precision of 0.08 dex, yield $= -1.86$ and $\sigma$ = 0.40. These values suggest that the stream is a tidally disrupted dwarf spheroidal galaxy of low luminosity. Photometry from the database of the SDSS indicates that this stream covers at least 106 deg$^2$ of the sky in the constellation Virgo. The name Virgo Stellar Stream is suggested.Comment: Replaced with revised version accepted for publication in ApJ Letters 13 pages 4 figure

Seismic Test of Solar Models, Solar Neutrinos and Implications for Metal-Rich Accretion

The Sun is believed to have been the recipient of a substantial amount of metal-rich material over the course of its evolution, particularly in the early stages of the Solar System. With a long diffusion timescale, the majority of this accreted matter should still exist in the solar convection zone, enhancing its observed surface abundance, and implying a lower-abundance core. While helioseismology rules out solar models with near-zero metallicity cores, some solar models with enhanced metallicity in the convection zone might be viable, as small perturbations to the standard model. Because of the reduced interior opacity and core temperature, the neutrino flux predicted for such models is lower than that predicted by the standard solar model. This paper examines how compatible inhomogeneous solar models of this kind are with the observed low and intermediate degree p-mode oscillation data, and with the solar neutrino data from the SNO Collaboration. We set an upper limit on how much metal-rich accretion took place during the early evolution of the Sun at about 2 Earth masses of iron (or about 40 Earth masses of meteoric material).Comment: Revision: 23 pages, 8 figures, 3 tables, to be published in ApJ, Sept 2002. Used newer neutrino cross sections, modified text accordingly, other minor revisions as wel

Spectroscopy of Bright QUEST RR Lyrae Stars: Velocity Substructures toward Virgo

Using a sample of 43 bright (V<16.1, distance <13 kpc) RR Lyrae stars (RRLS) from the QUEST survey with spectroscopic radial velocities and metallicities, we find that several separate halo substructures contribute to the Virgo overdensity (VOD). While there is little evidence for halo substructure in the spatial distribution of these stars, their distribution in radial velocity reveals two moving groups. These results are reinforced when the sample is combined with a sample of blue horizontal branch stars that were identified in the SDSS, and the combined sample provides evidence for one additional moving group. These groups correspond to peaks in the radial velocity distribution of a sample of F type main-sequence stars that was recently observed in the same directon by SEGUE, although in one case the RRLS and F star groups may not lie at the same distance. One of the new substructures has a very narrow range in metallicity, which is more consistent with it being the debris from a destroyed globular cluster than from a dwarf galaxy. A small concentration of stars have radial velocities that are similar to the Virgo Stellar Stream (VSS) that was identified previously in a fainter sample of RRLS. Our results suggest that this feature extends to distances as short as ~12 kpc from its previous detection at ~19 kpc. None of the new groups and only one star in the sample have velocities that are consistent with membership in the leading tidal stream from the Sagittarius Dwarf Spheroidal Galaxy, which some authors have suggested is the origin of the VOD.Comment: Accepted for publication in the A

Multi-Element Abundance Measurements from Medium-Resolution Spectra. III. Metallicity Distributions of Milky Way Dwarf Satellite Galaxies

We present metallicity distribution functions (MDFs) for the central regions of eight dwarf satellite galaxies of the Milky Way: Fornax, Leo I and II, Sculptor, Sextans, Draco, Canes Venatici I, and Ursa Minor. We use the published catalog of abundance measurements from the previous paper in this series. The measurements are based on spectral synthesis of iron absorption lines. For each MDF, we determine maximum likelihood fits for Leaky Box, Pre-Enriched, and Extra Gas (wherein the gas supply available for star formation increases before it decreases to zero) analytic models of chemical evolution. Although the models are too simplistic to describe any MDF in detail, a Leaky Box starting from zero metallicity gas fits none of the galaxies except Canes Venatici I well. The MDFs of some galaxies, particularly the more luminous ones, strongly prefer the Extra Gas Model to the other models. Only for Canes Venatici I does the Pre-Enriched Model fit significantly better than the Extra Gas Model. The best-fit effective yields of the less luminous half of our galaxy sample do not exceed 0.02 Z_sun, indicating that gas outflow is important in the chemical evolution of the less luminous galaxies. We surmise that the ratio of the importance of gas infall to gas outflow increases with galaxy luminosity. Strong correlations of average [Fe/H] and metallicity spread with luminosity support this hypothesis.Comment: 17 pages, 5 figures; accepted for publication in ApJ; minor corrections in v3; corrected typographical errors in Tables 1 and 3 in v

Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson\u27s Disease Off Episodes

Parkinson\u27s Disease (PD) is a common neurodegenerative disorder and the leading cause of disability. It causes significant morbidity and disability through a plethora of symptoms, including movement disorders, sleep disturbances, and cognitive and psychiatric symptoms. The traditional pathogenesis theory of PD involves the loss of dopaminergic neurons in the substantia nigra (SN). Classically, treatment is pursued with an assortment of medications that are directed at overcoming this deficiency with levodopa being central to most treatment plans. Patients taking levodopa tend to experience off episodes with decreasing medication levels, causing large fluctuations in their symptoms. These off episodes are disturbing and a source of morbidity for these patients. Opicapone is a novel, peripherally acting Catechol-O-methyl transferase (COMT) inhibitor that is used as adjunctive therapy to carbidopa/levodopa for treatment and prevention of off episodes. It has been approved for use as an adjunct to levodopa since 2016 in Europe and has recently (April 2020) gained FDA approval for use in the USA. By inhibiting COMT, opicapone slows levodopa metabolism and increases its availability. Several clinical studies demonstrated significant improvement in treatment efficacy and reduction in duration of off episodes. The main side effect demonstrated was dyskinesia, mostly with the 100mg dose, which is higher than the approved, effective dose of 50mg. Post-marketing surveillance and analysis are required to further elucidate its safety profile and contribute to patient selection. This paper reviews the seminal and latest evidence in the treatment of PD off episodes with the novel drug Opicapone, including efficacy, safety, and clinical indications