Analysis of densification mechanisms of dry granulated materials

International audienceDry granulation by roll compaction is a continuum manufacturing process to produce granules with improved flowability which can further be easily used in tableting process. However, the granules are non-homogeneous in density and have non-spherical shapes which impact their densification behaviour during die-compaction. The aim of this study was to investigate both the densification mechanism and the failure strength of granules of microcrystalline cellulose (MCC) and mannitol using Cooper-Eaton and Adams models. For both materials, the Cooper-Eaton approach led to the quantification of fractional volume compaction by particle rearrangement and by plastic deformation respectively to explain the difference in densification behaviour of raw material and granules. Moreover, the model showed its ability to capture the effect of granule density and granule sizes and to differentiate the densification mechanisms of MCC as a plastic material and mannitol as a brittle material. The Adams model was used to compute the failure strength of single granule from in-die compression data. The obtained results of the granules were in the range [0.6–1.43  MPa]. However, regarding the effect of granule density, the model showed mixed results indicating that the model is not representative of the studied granules which are not spherical and have a relatively wide range of sizes, nevertheless, the model was derived for near spherical particles with a narrow size distribution

Hypothalamic Α 2 -Noradrenergic Receptor System Relation to Dietary, Genetic, and Hormonally Induced Obesity

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73970/1/j.1749-6632.1989.tb53313.x.pd

Dissolved oxygen isotope modelling refines metabolic state estimates of stream ecosystems with different land use background

Dissolved oxygen (DO) is crucial for aerobic life in streams and rivers and mostly depends on photosynthesis (P), ecosystem respiration (R) and atmospheric gas exchange (G). However, climate and land use changes progressively disrupt metabolic balances in natural streams as sensitive reflectors of their catchments. Comprehensive methods for mapping fundamental ecosystem services become increasingly important in a rapidly changing environment. In this work we tested DO and its stable isotope ($^{18}$O$^{16}$O) ratios as novel tools for the status of stream ecosystems. For this purpose, six diel sampling campaigns were performed at three low-order and mid-latitude European streams with different land use patterns. Modelling of diel DO and its stable isotopes combined with land use analyses showed lowest P rates at forested sites, with a minimum of 17.9 mg m$^{-2}$ h$^{-1}$. Due to high R rates between 230 and 341 mg m$^{-2}$ h$^{-1}$ five out of six study sites showed a general heterotrophic state with P:R:G ratios between 0.1:1.1:1 and 1:1.9:1. Only one site with agricultural and urban influences showed a high P rate of 417 mg m$^{-2}$ h$^{-1}$ with a P:R:G ratio of 1.9:1.5:1. Between all sites gross G rates varied between 148 and 298 mg m$^{-2}$ h$^{-1}$. In general, metabolic rates depend on the distance of sampling locations to river sources, light availability, nutrient concentrations and possible exchanges with groundwater. The presented modelling approach introduces a new and powerful tool to study effects of land use on stream health. Such approaches should be integrated into future ecological monitoring

Taboos: Traditional beliefs and customs for resource management in the western Himalaya

575-581People residing in interior areas of the Himalaya are highly dependent on natural resources and thus have evolved their own beliefs and customs, the taboos, for conserving resources. Taboos form an important component of tribal lifestyle and guide sustainable utilization and management of natural resources. The present study was carried out in the higher reaches of Himachal Pradesh that are known for their rich bio-cultural diversity. The study aimed at documenting and classifying taboos prevalent in the area. For this, field surveys were carried out and interactions were held with the local people (n=210) using semi-structured interviews and focus group discussions. The results revealed a prevalence of 22 taboos that were mainly related to forest, water, farmland, and food resources. Of the total taboos, the maximum belonged to the segment and method category taboos (32% each) while the minimum (5%) were species-specific taboos. Adherence to taboos is high and breaking them is believed to bring the wrath of God. They, thus, are important for resource management. Studies targeting the history of taboos and their policy implications are much desired

Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalaya

The importance of medicinal plants in traditional healthcare practices, providing clues to new areas of research and in biodiversity conservation is now well recognized. However, information on the uses for plants for medicine is lacking from many interior areas of Himalaya. Keeping this in view the present study was initiated in a tribal dominated hinterland of western Himalaya. The study aimed to look into the diversity of plant resources that are used by local people for curing various ailments. Questionnaire surveys, participatory observations and field visits were planned to illicit information on the uses of various plants. It was found that 35 plant species are commonly used by local people for curing various diseases. In most of the cases (45%) under ground part of the plant was used. New medicinal uses of Ranunculus hirtellus and Anemone rupicola are reported from this area. Similarly, preparation of "sik" a traditional recipe served as a nutritious diet to pregnant women is also not documented elsewhere. Implication of developmental activities and changing socio-economic conditions on the traditional knowledge are also discussed

Taking a leaf from Jantri for traditional medicament- an ancient manuscript in Tankri

451-458The present paper highlights the importance vis-à-vis plight of a traditional script Tankri of Chamba, Himachal Pradesh. Through surveys in 70 villages that involved interviews with 550 residents, only one respondent was found to be versed in it. He uses an ancient manuscript named Jantri, scripted in Tankri, for prescribing medicines. Interactions and literature review revealed that Tankri was once a princely script of Chamba that now has no takers. Tankri originated from the Brahmic family of scripts and the Jantri holds information on uses of natural resources for curing human and animal related ailments. A total of 32 resources that include 24 of plant origin, 3 of animal origin, and 5 minerals were used for making formulations to cure a total of 13 diseases. Writing amulets in Tankri on tree bark using traditional ink was found to be a characteristic of the region. Unfortunately, the script is fast disappearing and so is the knowledge associated with it. Its disappearance would be a great loss to mankind. It is high time that conservation and decoding of such scripts is prioritized. Developing a database of knowledge holders and digitizing the information recorded in Tankri may be the starting point of this

LANDSLIDE HAZARD ZONATION IN AND AROUND KEDARNATH REGION AND ITS VALIDATION BASED ON REAL TIME KEDARNATH DISASTER USING GEOSPATIAL TECHNIQUES

Landslides are one of the frequently happening disasters in this hilly state of Uttarakhand which accounts to the loss of lives and property every year especially during the rainy season which lead to affect the families. With the development of satellite observation technique, advanced data analysis tool and new modeling techniques landslide hazard zonation map can be prepared.In the present study, Landslide Hazard Zonation (LHZ) for Kedarnath to Augustmuni region of Rudraprayag district of Uttarakhand state was carried out using Remote Sensing and GIS technique. For the preparation of LHZ map, year 2010 high resolution satellite data have been used. After preprocessing of the data various thematic layers are prepared in GIS environment. The weighted-rating system technique were used for the LHZ map showing the five zones, namely “very low hazard”, “low hazard”, “moderate hazard”, “high hazard” and “very high hazard” . This map has been validated after the tragedy of Kedarnath in Uttarakhand, Total no. of 224 Landslides has been marked from Kedarnath to Augustmuni region just after the kedarnath tragedy in year 2013. When this landslides thematic layer is overlaid on LHZ, the study shows that approximately 50% landslides was there where in LHZ map high and very high hazard zones have been identified. After the tragedy our team workers have gone to the field, with the help of DGPS around 40 ground control points have been taken to validate our result. So by using this geospatial technique around 50% people’s life can be saved.</p