157 research outputs found
Solid-propellant rocket motor internal ballistic performance variation analysis, phase 2
The Monte Carlo method was used to investigate thrust imbalance and its first time derivative throughtout the burning time of pairs of solid rocket motors firing in parallel. Results obtained compare favorably with Titan 3 C flight performance data. Statistical correlations of the thrust imbalance at various times with corresponding nominal trace slopes suggest several alternative methods of predicting thrust imbalance. The effect of circular-perforated grain deformation on internal ballistics is discussed, and a modified design analysis computer program which permits such an evaluation is presented. Comparisons with SRM firings indicate that grain deformation may account for a portion of the so-called scale factor on burning rate between large motors and strand burners or small ballistic test motors. Thermoelastic effects on burning rate are also investigated. Burning surface temperature is calculated by coupling the solid phase energy equation containing a strain rate term with a model of gas phase combustion zone using the Zeldovich-Novozhilov technique. Comparisons of solutions with and without the strain rate term indicate a small but possibly significant effect of the thermoelastic coupling
A Monte Carlo investigation of thrust imbalance of solid rocket motor pairs
A technique is described for theoretical, statistical evaluation of the thrust imbalance of pairs of solid-propellant rocket motors (SRMs) firing in parallel. Sets of the significant variables, determined as a part of the research, are selected using a random sampling technique and the imbalance calculated for a large number of motor pairs. The performance model is upgraded to include the effects of statistical variations in the ovality and alignment of the motor case and mandrel. Effects of cross-correlations of variables are minimized by selecting for the most part completely independent input variables, over forty in number. The imbalance is evaluated in terms of six time - varying parameters as well as eleven single valued ones which themselves are subject to statistical analysis. A sample study of the thrust imbalance of 50 pairs of 146 in. dia. SRMs of the type to be used on the space shuttle is presented. The FORTRAN IV computer program of the analysis and complete instructions for its use are included. Performance computation time for one pair of SRMs is approximately 35 seconds on the IBM 370/155 using the FORTRAN H compiler
Application of Biotests for the Determination of Soil Ecotoxicity after Exposure to Biodegradable Plastics
Biodegradable plastics are mostly applied in packaging materials (e.g., shopping bags), waste collection bags, catering products, and agricultural applications. In this last case, degradation takes place directly in soil where biodegradable plastic products are intentionally left after use (e.g., mulch films for weeds control). Due to the growing volumes of biodegradable polymers and plastics, interest in their environmental safety is increasing and more research is carried out. Some attempt has been made to apply biotests, used in other sectors of environmental sciences, in the assessment of biodegradable plastics safety. In this work, the quality of soils after biodegradation of the bioplastics Mater-Bi has been assessed with a large array of biotests based on model organisms representative of the different trophic levels in the food chains of the edaphic and aquatic ecosystems. Mater-Bi was degraded under controlled conditions for 6 months at a 1% concentration. The selected organisms included bacteria and protozoa (Vibrio fischeri and Dictyostelium discoideum, respectively), the green alga Pseudokirchneriella subcapitata, plants (the monocotyledon Sorghum saccharatum and the dicotyledon Lepidium sativum), and invertebrates animals (Daphnia magna, a freshwater crustacean, and the Oligochaeta earthworm Eisenia andrei), using both acute and chronic endpoints. The results of the applied ecotoxicological tests showed that the Mater-Bi materials tested at very high doses did not affect the soil quality. Soil exposed to Mater-Bi has no noxious effects on edaphic organisms; in particular, mono and dicotyledon plants results, indicate that Mater-Bi plastic products are innocuous for agricultural uses. The use of more sensitive chronic endpoints allows to exclude possible effects at population level. This is the first time that such a comprehensive approach is applied to the assessment of possible ecotoxicity effects induced by biodegradable plastics in soil and represents a possible starting point for improved standardized testing schemes
Solid propellant rocket motor internal ballistics performance variation analysis, phase 3
Results of research aimed at improving the predictability of off nominal internal ballistics performance of solid propellant rocket motors (SRMs) including thrust imbalance between two SRMs firing in parallel are reported. The potential effects of nozzle throat erosion on internal ballistic performance were studied and a propellant burning rate low postulated. The propellant burning rate model when coupled with the grain deformation model permits an excellent match between theoretical results and test data for the Titan IIIC, TU455.02, and the first Space Shuttle SRM (DM-1). Analysis of star grain deformation using an experimental model and a finite element model shows the star grain deformation effects for the Space Shuttle to be small in comparison to those of the circular perforated grain. An alternative technique was developed for predicting thrust imbalance without recourse to the Monte Carlo computer program. A scaling relationship used to relate theoretical results to test results may be applied to the alternative technique of predicting thrust imbalance or to the Monte Carlo evaluation. Extended investigation into the effect of strain rate on propellant burning rate leads to the conclusion that the thermoelastic effect is generally negligible for both steadily increasing pressure loads and oscillatory loads
Effects of PAHs and dioxins on the earthworm Eisenia andrei: a multivariate approach for biomarker interpretation.
In this study, a battery of biomarkers was utilised to evaluate the stress syndrome induced in the earthworm Eisenia andrei by exposure to environmentally realistic concentrations of benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) in OECD soil. The set of tests was then employed to assess the toxicity of field soils contaminated with organic xenobiotic compounds (such as PAHs, dioxins and PCBs). Biomarker responses (comprising biomarkers of stress and of genotoxicity) varied depending on chemicals, dose and time of exposure; and among the different polluted field soils. The results highlighted an impairment of immune and metabolic functions and genotoxic damage in worms exposed also to lower bioavailable concentrations of toxic chemicals. Multivariate analysis of biomarker data showed that all different contaminated soils had a detrimental effect on the earthworms; control animals being clearly separated from the treated ones. A separation between temporal and concentration factors were also evident for B[a]P and TCDD treatments; and field contaminated soils were further differentiated reflecting a diverse contamination. Multivariate analysis also demonstrated that lysosomal membrane stability can be considered as a predictive tool of the adverse effects on worm health status provoked by increasing bioavailable concentrations of toxic chemicals
Mode of action of Cr(VI) in immunocytes of earthworms: Implications for animal health
Chromium (Cr) is one of the major and most detrimental pollutant, widely present in the environment as a result of several anthropogenic activities. In mammalian cells, Cr(VI) is known to enhance reactive oxygen species (ROS) production and to cause toxic and genotoxic effects. Less commonly investigated are the effects and mode of action of this contaminant in invertebrates, particularly in soil organisms. In this work, earthworms of the species Eisenia andrei were exposed for 1 and 3 days to various sublethal concentrations of Cr(VI) (2, 15, 30 µg mL−1) using the paper contact toxicity test. In amoeboid leukocytes we investigated intracellular ROS and lipoperoxide production, oxidative DNA damage, and the effects on different cell functions. The analysis of the results shows that Cr(VI) triggered severe adverse reactions; the first events were an increase of intracellular ROS levels, generating in the cells oxidative stress conditions leading to membrane lipid peroxidation and oxidative DNA damage. Lysosomes showed relevant changes such as a strong membrane destabilization, which was accompanied by an increased catabolism of cytoplasmic proteins and accumulation of lipofuscin. With an increase in the dose and/or time of exposure, the physiological status of intracellular organelles (such as lysosomes, nucleus and mitochondria) showed further impairment and amoebocyte immune functions were adversely affected, as shown by the decrease of the phagocytic activity. By mapping the responses of the different parameters evaluated, diagnostic of (oxidative) stress events, against lysosomal membrane stability, a “health status” indicator (able to describe the stress syndrome from its early phase to pathology), we have shown that this biomarker is suitable as a prognostic test for health of earthworms. This is viewed as a crucial step toward the derivation of explanatory frameworks for prediction of pollutant impact on animal health
Mucoadhesive tablets for buccal administration containing sodium nimesulide.
The possibility of improving the flux of nimesulide across the buccal mucosa using the drug in the form of a sodium salt was investigated in our study. The salt form may increase to flux across buccal membrane, starting from a suspension; its lower permeation coefficient is compensated by a higher concentration gradient. The salt was inserted into a mucoadhesive tablet for buccal administration. The tablets were designed to prevent the loss of the drug into the saliva by means of a protective layer and placed on the area not in contact with the mucosa. Ten volunteers were used. The in vitro release from mucoadhesive tablets was examined through a porcine buccal mucosa, using a standard Franz cell, modified for present purposes. The advantages of a higher concentration gradient for the flux, related to a higher solubility of the salt, and to a sufficiently high permeation coefficient of the drug, despite the ionized form, could not be completely exploited, because the composition of the formulation destroys the chemical form of the drug
Ceramiche d\u2019uso comune, anfore e materiali laterizi provenienti dall\u2019Edificio termale di Hadrianopolis (Sofratik\ueb \u2013 Albania)
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