6 research outputs found
Copy number variations in 119 Chinese children with idiopathic short stature identified by the custom genome-wide microarray
Full text linkTuneable endogenous mammalian target complementation via multiplexed plasmid-based recombineering
No full textPeripheral blood cells from children with RASopathies show enhanced spontaneous colonies growth in vitro and hyperactive RAS signaling
No full textTyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
Get PDFThe NLRP3 inflammasome is central to a variety of inflammatory diseases, but how it is regulated to prevent excessive inflammation is not clear. Here the authors show that NLRP3 activation causes SHP2 translocation to the mitochondria to interact with and dephosphorylate ANT1, thus stabilizing the mitochondria and preventing release of proinflammatory mitochondrial DNA and ROS
