Balanced Allocations and Double Hashing

Double hashing has recently found more common usage in schemes that use multiple hash functions. In double hashing, for an item $x$, one generates two hash values $f(x)$ and $g(x)$, and then uses combinations $(f(x) +k g(x)) \bmod n$ for $k=0,1,2,...$ to generate multiple hash values from the initial two. We first perform an empirical study showing that, surprisingly, the performance difference between double hashing and fully random hashing appears negligible in the standard balanced allocation paradigm, where each item is placed in the least loaded of $d$ choices, as well as several related variants. We then provide theoretical results that explain the behavior of double hashing in this context.Comment: Further updated, small improvements/typos fixe

Analisis Pengaruh Bauran Pemasaran Terhadap Kepuasan Dan Loyalitas Pelanggan Di Karita Muslim Square YOGYAKARTA

Syari'ah marketing is a business discipline strategies that directs to the process of supply, demand and value alteration from an initiator to its stakeholders based on Islamic principles. And also about customer's satisfaction which is a basic concept of marketing and success factor for organization in business as well. It could be viewed from the fact that there are many companies emphasize the importance of giving their customers high level of satisfaction. Most companies measure the satisfaction of their customer and hope the customer will loyal in choosing the company's product or service, if the customer satisfaction is high. So that it would cause the customer's loyalty to the company.This research is attempted to measure the influence of marketing mix which are consist of four aspects product, price, location or distribution and promotion to the customer's satisfaction, then their accordance to Islamic Principles and to measure the influence of customer's satisfaction to customer's loyalty in Karita Muslim Square Yogyakarta. This research is an analytic descriptive research in quantitative and qualitative uses the method of distributing questionnaire in order to gain primary data by non probability sampling technique for 100 respondents of the customer of Karita Muslim Square Yogyakarta. The result of this research shows that product and price significantly influence to the customer's satisfaction. But location or distribution gives the negative influence and doesn't significantly toward the customer's by the standardized coefficient value -0.26, while promotion gives the positive influence but doesn't significantly toward customer's satisfaction by the significant value 0.467 > á (0.05). Price is the strongest aspect which gives the influence to customer's satisfac- tion by the significance value 0,000. Meanwhile, from simple regression it was proven that customer satisfaction positively influence loyalty intentions. Those four marketing mix which were offered by Karita Muslim Square have been according to Islamic Principles as have appropriated by Al-Qur'an and Hadits teachings

Celah Riba Pada Perbankan Syariah Serta Konsekwensinya Terhadap Individu, Masyarakat Dan Ekonomi

Harta adalah perhiasan dunia yang diciptakan Allah untuk umat manusia. Harta merupakan sesuatu yang sering diperebutkan manusia dan bahkan cara memperolehnya pun bisa dilakukan dengan cara yang salah; seperti riba, mencuri, merampok dan ghasab. Riba adalah jenis transaksi yang diharamkan Islam karena merugikan salah satu pihak dari dua pihak yang bertransaksi. Meskipun demikian, seiring dengan perkembangan jaman transaksi ribawi di dunia perbankan dewasa ini semakin sulit dihindari, tidak terkecuali pada lembaga keuangan yang berlabelkan syariah. Berawal dari motivasi untuk menggerakkan perekonomian melalui lembaga keuangan yang Islami, masyarakat muslim justru terlena dengan transaksi-transaksi ribawi yang direkayasa supaya tidak mencolok keharamannya. Secara umum masih terdapat transaksi ribawi dalam Lembaga Keuangan Syariah yang perlu dibenahi dan dikaji lebih lanjut sehingga betul-betul terlepas dari dosa besar riba. Karena mengikuti ketetapan Allah dan RasulNya adalah bagian dari ibadah yang mutlak dan tidak dapat ditawar dengan alasan kemodernan dan permintaan pasar atau persaingan. Melagalkan riba akan memberikan dampak negatif bagi individu pelaku, kelompok masyarakat dan ekonomi suatu negara, bahkan sangat terkait dengan terkabulnya doa seorang mukmin di sisi Allah Swt. Maka melalui karya tulis ini, penulis berharap kedepannya ada tahapan lanjutan untuk perbaikan transaksi di perbankan syariah sehingga tercapai tujuan penghapusan riba yang sesungguhnya, sehingga sistem ekonomi Islam betul-betul menciptakan keharmonisan ekonomi yang berkeadilan

Abdominal Ultrasound and Abdominal Radiograph to Diagnose Necrotizing Enterocolitis in Extremely Preterm Infants

Necrotizing enterocolitis (NEC) is an important contributor towardmortality in extremely premature infants and Very Low Birth Weight(VLBW) infants. The incidence of NEC was 9% in VLBW infants(birth weight 401 to 1,500 grams) in the Vermont Oxford Network(VON, 2006 to 2010, n = 188,703).1 The incidence of NEC was 7%in 1993, increased to 13% in 2008, and decreased to 9% in extremelypreterm infants (22 to 28 weeks gestation) in the Neonatal ResearchNetwork Centers (1993 to 2012).2 The incidence of surgically treatedNEC varies from 28 to 50% in all infants who develop NEC.3 SurgicalNEC occurred in 52% in the VON cohort.1 In this cohort, the odds ofsurgery decreased by 5% for each 100 gram increase in birth.The incidence of surgical NEC has not decreased in the pastdecade.4 The mortality from NEC is significantly higher in infantswho need surgery compared to those who did not (35% versus 21%).1The case fatality rate among patients with NEC is higher in thosesurgically treated (23 to 36%) compared to those medically treated (5to 24%).3 In addition to surgery, NEC mortality rates are influencedby gestational age, birth weight,1,2,5 assisted ventilation on the day ofdiagnosis of NEC, treatment with vasopressors at diagnosis of NEC,and black race.6,7Extremely preterm infants who survive NEC are at risk for severeneurodevelopmental disability and those with surgical NEC have asignificantly higher risk of such delays (38% surgical NEC versus 24%medical NEC).8 Diagnosis of necrotizing enterocolitis is challengingand it is usually suspected based on non-specific clinical signs. Bell’scriteria and Vermont-Oxford Network criteria help in the diagnosisof NEC.Bell’s criteria, commonly used for diagnosis, staging, and planningtreatment of NEC, were described in 1978 and modified in 1986.9,10Bell’s stage I signs are non-specific: temperature instability, lethargy,decreased perfusion, emesis or regurgitation of food, abdominal distension,recurrent apnea, and on occasion, increased support withmechanical ventilation. Abdominal distension and emesis are morecommon than bloody stools in very preterm infants compared to terminfants.7 Abdominal radiographic findings are an integral part of Bell’scriteria. Identification of Bell’s stage I NEC (early NEC) with abdominalradiograph is challenging, as the features on abdominal radiograph(normal gas pattern or mild ileus) are non-specific. With progressionof NEC to Bell Stage IIA, the symptoms (grossly bloody stools,prominent abdominal distension, absent bowel sounds) and featureson abdominal radiographs (one or more dilated loops and focal pneumatosis)are more specific.On the other hand, the Vermont Oxford Network criteria for NECconsist of at least one physical finding (bilious gastric aspirate oremesis, abdominal distension or occult/gross blood in the stool inthe absence of anal fissure) and at least one feature on abdominalradiograph (pneumatosis intestinalis, hepatobiliary gas, or pneumoperitoneum).1 These features correspond to Bell Stage IIA or StageIIB and are not features of early NEC. Thus relying solely on abdominalradiograph for diagnosis of early NEC, as is practiced currently,has significant drawbacks especially in extremely premature infants.7Ultrasound has been suggested to improve the percentage of infantsdiagnosed with early NEC.11 However, this imaging modality is notused routinely in the diagnosis or management of NEC.As the incidence of surgical NEC and mortality from NEC continuesto be high, the literature to demonstrate the shortcomings ofabdominal radiographs and promise of abdominal ultrasound in diagnosisof NEC is reviewed

Classification of Breast Cancer Subtypes by combining Gene Expression and DNA Methylation Data

Summary Selecting the most promising treatment strategy for breast cancer crucially depends on determining the correct subtype. In recent years, gene expression profiling has been investigated as an alternative to histochemical methods. Since databases like TCGA provide easy and unrestricted access to gene expression data for hundreds of patients, the challenge is to extract a minimal optimal set of genes with good prognostic properties from a large bulk of genes making a moderate contribution to classification. Several studies have successfully applied machine learning algorithms to solve this so-called gene selection problem. However, more diverse data from other OMICS technologies are available, including methylation. We hypothesize that combining methylation and gene expression data could already lead to a largely improved classification model, since the resulting model will reflect differences not only on the transcriptomic, but also on an epigenetic level. We compared so-called random forest derived classification models based on gene expression and methylation data alone, to a model based on the combined features and to a model based on the gold standard PAM50. We obtained bootstrap errors of 10-20% and classification error of 1-50%, depending on breast cancer subtype and model. The gene expression model was clearly superior to the methylation model, which was also reflected in the combined model, which mainly selected features from gene expression data. However, the methylation model was able to identify unique features not considered as relevant by the gene expression model, which might provide deeper insights into breast cancer subtype differentiation on an epigenetic level.</jats:p

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions

A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice