FAST FUEL TEST REACTOR-FFTR CONCEPTUAL DESIGN STUDY

The Fast Fuel Test Reactor (FFTR) is a nuclear facility for the purpose of irradiating samples of fuels and structural components for use in fast reactors. The core consisis of a plate type element in a square configuration. Beryllium metal between the fuel elements is used to obtain a neutron energy spectrum in the hard intermediate region. Cooling of the core and test specimens is accomplished by means of liquid sodium. The design concept was carried through in sufficient degree in the following areas of preliminary concern: number and size of irradiation facilities, sample power requirements, plant layout to evaluate site requirements, plant and nuclear design parameters to evaluate essential equipment requirements. plant-capital-cost estimate, annual- operating-cost estimate, and estimate of construction time schedule. (W.D.M.

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden

Progress & Problems in Education for Librarianship (Book Rerview)

published or submitted for publicatio

On Developing and Administration Library for a Foreign University

published or submitted for publicatio

Experimental Breeder Reactor-II (EBR-II) Shield Design

A description of the EBR-II shield and the methods employed in arriving at the final design are presented. The major shield design problems for that reactor are enumerated and discussed. (auth

Atomic Energy Commission Reports

Report describing the EBR-II shield and the methods employed in arriving at the final design. The major shield design problems for that reactor are enumerated and discussed