Editorial: Longitudinal development of aerobic fitness in children

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Prognostic significance of FLT3-ITD length in AML patients treated with intensive regimens

FLT3-ITD mutations are detected in approximately 25% of newly diagnosed adult acute myeloid leukemia (AML) patients and confer an adverse prognosis. The FLT3-ITD allelic ratio has clear prognostic value. Nevertheless, there are numerous manuscripts with contradictory results regarding the prognostic relevance of the length and insertion site (IS) of the FLT3-ITD fragment. We aimed to assess the prognostic impact of these variables on the complete remission (CR) rates, overall survival (OS) and relapse-free survival (RFS) of AML patients with FLT3-ITDmutations. We studied the FLT3-ITD length of 362 adult AML patients included in the PETHEMA AML registry. We tried to validate the thresholds of ITD length previously published (i.e., 39 bp and 70 bp) in intensively treated AML patients (n = 161). We also analyzed the mutational profile of 118 FLT3-ITD AML patients with an NGS panel of 39 genes and correlated mutational status with the length and IS of ITD. The AUC of the ROC curve of the ITD length for OS prediction was 0.504, and no differences were found when applying any of the thresholds for OS, RFS or CR rate. Only four out of 106 patients had ITD IS in the TKD1 domain. Our results, alongside previous publications, confirm that FLT3-ITD length lacks prognostic value and clinical applicability. © 2021, The Author(s)

Using motivational techniques to reduce cardiometabolic risk factors in long term psychiatric inpatients: A naturalistic interventional study

Background People with severe mental illness have markedly reduced life expectancy; cardiometabolic disease is a major cause. Psychiatric hospital inpatients have elevated levels of cardiometabolic risk factors and are to a high degree dependent of the routines and facilities of the institutions. Studies of lifestyle interventions to reduce cardiometabolic risk in psychiatric inpatients are few. The current study aimed at assessing the feasibility and effects of a lifestyle intervention including Motivational Interviewing (MI) on physical activity levels, cardiometabolic risk status and mental health status in psychotic disorder inpatients. Methods Prospective naturalistic intervention study of 83 patients at long term inpatient psychosis treatment wards in South-Eastern Norway. Patients were assessed 3–6 months prior to, at start and 6 months after a life-style intervention program including training of staff in MI, simple changes in routines and improvements of facilities for physical exercise. Assessments were done by clinical staff and included level of physical activity, motivation, life satisfaction, symptom levels (MADRS, AES-C, PANSS, and GAF) as well as anthropometric and biochemical markers of cardiometabolic risk. A mixed model was applied to analyze change over time. Results A total of 88% of patients received MI interventions, with a mean of 2.5 MI interventions per week per patient. The physical activity level was not increased, but activity level was positively associated with motivation and negatively associated with positive symptoms. Triglyceride levels and number of smokers were significantly reduced and a significant decrease in symptom levels was observed. Conclusions The current results suggest that a simple, low cost life-style intervention program focusing on motivational change is feasible and may reduce symptoms and improve lifestyle habits in psychosis patients in long term treatment facilities. Similar programs may easily be implemented in other psychiatric hospitals.submittedVersio

Influence of climate on radial growth of holm oaks (Quercus ilex subsp ballota desf) from SW Spain

A total of 47 trunk sections from Holm Oak (Quercus ilex subsp. ballota Desf) trees growing at two different sites at the Extremadura region (SW Spain) were considered in the computation of a regional tree-ring chronology useful to interpret the tree-ring/Mediterranean climate relationships. This is the first dendroclimatological research of Holm Oaks conducted to reveal its potential use as a climatic proxy. The obtained tree-ring chronologies were compared with climatic parameters based on monthly, seasonal and annual rainfall, and monthly maximum, minimum and average temperature. The best correlations were obtained with maximum temperatures during the period between previous winter and early spring. Influence of rainfall was less relevant. Growth of this species indicates a typical bimodal (spring and autumn) strategy that avoids low winter temperatures and summer drought. Despite some technical difficulties recognizing tree rings in Holm Oaks, its good sensitivity to climate variability and its wide distribution and longevity (~800 years), allow us to consider this species as a good candidate for temperature reconstructions in the Mediterranean Basin

Cardiorespiratory fitness and body mass index values in 9-year-old rural Norwegian children

Aim: To describe cardiorespiratory fitness and body mass index (BMI) values in a representative population of 9-year-old Norwegian children in two rural communities and compare present values with previous findings. Methods: Two hundred and fifty-nine 9-year-old children were invited, and 256 participated in this study. Maximal oxygen uptake was directly measured during a continuous progressive treadmill protocol. Body mass and height were also measured. Results: The mean ± SD relative maximal oxygen uptake was 52.8 ± 6.5 for boys and 46.9 ± 7.2 mL/kg/min for girls. Eight percent of the boys and 16.8% of the girls were classified as overweight, and 1.6% of the boys and 6.9% of the girls as obese. Mean age, body mass, height and Ponderal index were not significantly different between sexes. Girls had a higher BMI than boys (p = 0.05). Conclusion: Compared to earlier Norwegian studies, children's BMI values seem to have increased substantially. This increase is most pronounced in girls. When assessing these differences using the PI, this increase is less marked. Comparing maximal oxygen uptake data with that in earlier Nordic studies, there is no evidence that fitness has declined among 9-year olds. However, the limitations of the few earlier studies make reliable comparisons difficult

Ekstrem korttidsnedbør på Østlandet fra pluviometer og radar data

Korttidsnedbør på Østlandet er studert ved bruk av pluviometer-målinger og radardata. Pluviometerdataene er brukt til studier av ekstreme nedbørmengder for ulike varigheter, for å studere trender og geografiske forskjeller og til å produsere Intensitet-Varighet-Frekvens (IVF) statistikk. Data fra værradar og pluviometre i Østlands-området er brukt til detaljerte studier av romlige mønstre i episoder med kraftig nedbør og til å vurdere sammenheng mellom 1-times nedbørintensitet fra radar og bakkemålinger

Mono- and dinuclear osmium N,N′-di- and tetraphenylbipyridyls and extended bipyridyls. Synthesis, structure and electrochemistry

The efficient synthesis of mono- and dinuclear Os(iv) bipyridyl complexes is reported. These compounds show a two-step oxidation process leading to notable structural changes, which are reflected in their emission properties. During the second oxidation process a tetracation with a hydride-dihydrogen structure (instead of a trihydride) is formed. This results in a significant bathochromic shift of the emission band, accompanied by a moderate increase in intensity. This journal is © 2013 The Royal Society of Chemistry.Financial support from grants CTQ-2010-20414-C02-01/BQU (to MAS), CTQ2011-23459 (to MAE) and Consolider Ingenio 2010 (CSD2007-00006) from the MINECO, Diputación General de Aragón (E35), Comunidad de Madrid (P2009/PPQ1634-AVANCAT) (UCM group), and European Social Fund is acknowledged. I.F. and F.O. are Ramón y Cajal and Juan de la Cierva fellows, respectively. M.M.O is an FPI fellow.Peer Reviewe