_Streptomyces_ sp. as predators of bacteria

Background: The ecological role of actinomycetes and their secondary metabolites is not yet completely understood. 
Hypothesis: Actinomycetes and Streptomyces sp. in particular, are non-obligate predators of bacteria in soil. 
Evidence: Ability to grow on live bacterial cells as a sole source of nutrients. Prey cell lysis accompanying growth. Circumstantial evidence for the involvement of antimicrobials along with enzymes.
Implications: This finding may open up a new source of novel secondary metabolites from the genus

Ectopic Prostatic and Seminal Vesicle Tissue Confusing as Metastatic Adenocarcinoma

Ectopic prostatic tissue and seminal vesicle at pericolic fat is extremely rare. The nodules in the pericolic fat could raise a dilemma of metastatic deposits in cases of rectal adenocarcinoma. A 61 years old male underwent abdomino-perineal resection for rectal carcinoma. Nodules along with lymph nodes from pericolic fat were sampled to assess the spread. Histopathological and immunohistochemical staining of one nodule confirmed it to be the prostatic tissue while another nodule to be seminal vesicle. Seminal vesicle and prostatic heterotopia is significant in several respects, either symptomatic or asymptomatic, as the ectopic tissue can be endoscopically and histologically confused with malignancy of urinary or lower gastrointestinal system and may reflect divergent differentiation or a malformative process

A QUESTIONNAIRE BASED SURVEY TO ASSESS THE KNOWLEDGE, ATTITUDE AND PRACTICES OF AYURVEDIC PRACTITIONERS TOWARDS MASANUMASIK KASHAYAS

For a healthy pregnancy and delivery of a normal child, different group of medicines taken for each month of pregnancy is described in Ayurveda as Masanumasik Kashayas (monthly antenatal decoctions). Objectives: To assess the knowledge, attitude and practice of Ayurvedic practitioners regarding Masanumasik Kashayas. Methodology: Following ethical approval, a cross-sectional descriptive survey was conducted among Ayurvedic physicians from Mumbai region. Results: Of 130 questionnaires distributed, 120 physicians responded (92%). Although all the physicians were aware that Masanumasik Kashayasare described in the Samhitas, only 60% knew the number of Kashayas (decoctions). 85% knew the rationale for prescribing these Kashaya s(decoctions) and 93% agreed that these Kashayas (decoctions) improved pregnancy outcome. However, in clinical practice, 45% participants said that they prescribed Kashayas (decoctions) only in patients with bad obstetric history while 52.5% prescribed in regular ante-natal care. 83% preferred Vati (tablet) form rather than Kashaya (decoction) as patient compliance was better. All physicians who prescribed said that there were no adverse complaints and the pregnancy outcome was good. Conclusion: The study thus showed that all Ayurvedic practitioners were still well versed with Masanumasik Kashayas and prescribed these kashayas (decoctions) for a good pregnancy outcome in clinical practice with some modifications like usage of only 9 Kashayas (decoctions) and Vati form (tablet)

A double blind, randomized, placebo controlled, phase IV, proof-of-concept, comparative study to evaluate the efficacy and safety of Swasawin asthaloc tablets when given as add-on therapy in patients suffering from mild to moderate persistent bronchial asthma

Background: Asthma, known as “Tamaka Shwasa” in Ayurveda, as a chronic inflammatory disorder of the airways associated with increased airway hyper-responsiveness, recurrent episodes of wheezing, breathlessness, chest tightness and coughing, particularly at night/early morning. The key component to improving control and preventing attacks is the avoidance of triggers. Swasawin Asthaloc tablet, a polyherbal proprietary medication, is claimed to be effective in asthma. The Objective of the study was to evaluate the safety and efficacy of Swasawin Asthaloc tablets when given as add-on therapy to patients suffering from mild to moderate persistent bronchial asthma.Methods: The study was initiated after receiving Institutional Ethics Committee approval. Patients suffering from mild-to-moderate persistent bronchial asthma were randomized to 2 study groups after written informed consent process for 6 months. Group I received the study medication Swasawin Asthaloc tablet (1 tablet twice daily) in addition to regular anti-asthmatic medications (inhaler ± oral medications). Group II received Placebo tablets in a similar dose as add-on therapy. The study efficacy parameters included spirometry, breath holding time (BHT), Asthma symptom score and Ayurvedic Asthma symptom score.Results: 60 patients were enrolled in the study, of which 50 patients completed the study. In case of spirometry, both FEV1 and PEFR values showed statistically significant improvement at the end of 6 months therapy. Significant improvement in the Breath Holding Time (BHT), Ayurvedic Asthma symptom score and Asthma symptom score was observed in the active group as compared to the baseline (p <0.001).Conclusions: Add-on therapy with Swasawin Asthaloc tablets helped in reducing bronchial inflammation and improving asthmatic symptoms by virtue of its anti-inflammatory, bronchodilatory and antihistaminic properties. Hence it can be used as add-on therapy in patients with mild-to-moderate persistent bronchial asthma and may decrease the need for rescue medications especially steroids

Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes

The modulation of radiation induced lipid peroxidation in synaptosomes by iron (II) and iron (III) complexes of two naturally occurring and therapeutically relevant naphthoquinones viz. 5,hydroxy-1,4 naphthoquinone; juglone and 2,hydroxy-1,4 naphthoquinone; lawsone, have been studied. At lower concentrations the complexes enhance lipid peroxidation predominantly through redox cycling as observed for Fe(II)- juglonate while at higher concentrations the complexes tend to limit lipid peroxidation through fast recombinations

A short note on Magnetized Black-hole in Non-linear Electrodynamics

We have analyzed the thermodynamic properties of magnetized black-hole in the background of non-linear electrodynamics with two parameters $\beta$ and $\gamma$. We have studied the Bekenstein-Hawking entropy, Hawking temperature, specific heats in two-dimesional surface plots as a function of event horizon ($r_{+}$) and $\gamma$. We showed the variation profiles of the above thermodynamic parameters for $\gamma$ [$0 \rightarrow 1$]. We identified regions of parameters for the possible phase-transitions and the stability of the black-holes.Comment: 6 pages, 8 figure

Derivatization Ion Chromatography for the Determination of Monoethanolamine in Presence of Hydrazine in PHWR Steam-Water Circuits

A simple, rapid and accurate method for the determination of monoethanolamine (MEA) in PHWR steam-water circuits has been developed. MEA is added in the feed water to provide protection against corrosion while hydrazine is added to scavenge dissolved oxygen. The quantitative determination of MEA in presence of hydrazine was accomplished using derivatization ion chromatography with conductometric detection in nonsuppressed mode. A Metrosep cation 1-2 analytical column and a Metrosep cartridge were used for cation separation. A mixture of 4 mM tartaric acid, 20% acetone and 0.05 mM HNO3 was used as eluent. Acetone in the mobile phase leads to the formation of different derivatives with MEA and hydrazine. The interferences due Na+ and NH4 + were eliminated by adopting a simple pretreatment procedure employing OnGuard-H cartridge. The limit of detection limit of MEA was 0.1 μg mL−1 and the relative standard deviation was 2% for the overall method. The recovery of MEA added was in the range 95%–102%. The method was applied to the determination of MEA in steam generator water samples

Nearly Static Magnetized Kerr Black-hole in Non-linear Electrodynamics

We have analyzed the thermodynamics of slowly rotating magnetized Kerr black-hole, with typical spin parameter $a\le 0.1$ (nearly static) in the background of non-linear electrodynamics. In particular we have studied the Bekenstein-Hawking entropy, Hawking temperature, angular momentum, specific heats and identified regions of parameters for possible phase-transitions. It turns out that once the stability lost the black-hole never come back to its original stable position.Comment: 9pages, 12 figure

DESIGNING EFFICIENT LOCALIZED SURFACE PLASMON RESONANCE-BASED SENSING PLATFORMS: OPTIMIZATION OF SENSOR RESPONSE BY CON-TROLLING THE EDGE LENGTH OF GOLD NANOPRISMS

poster abstractOver the last few years, the unique localized surface plasmon resonance (LSPR) properties of plasmonic nanostructures have been used to design la-bel-free biosensors. In this research, we demonstrate that it is the difference in edge length of gold nanoprisms that significantly influences their bulk re-fractive index sensitivity and local sensing efficiency. Nanoprisms with edge lengths in the range of 28-51 nm were synthesized by the chemical-reduction method and sensing platforms were fabricated by chemisorptions of these nanoprisms onto silanized glass substrates. The plasmonic nanosensors prepared from 28 nm edge length nanoprisms exhibited the largest sensitivity to change in bulk refractive index with a value of 647 nm/RIU. The refractive index sensitivity decreased with increasing edge length, with nanoprisms of 51 nm edge lengths displaying a sensitivity of 384 nm/RIU. In contrast, we found that the biosensing efficiency of sensing platforms modified with biotin increased with increasing edge length, and the sensing platforms fabricated from 51 nm edge length nanoprisms displaying the highest local sensing efficiency. The lowest concentration of streptavidin that could be measured reliably was 1.0 pM and the limit of detection for the sensing platforms fabricated from 51 nm edge length nanoprisms was 0.5 pM, which is much lower than found with gold bipyramids, nanostars, and nanorods