Distribution and Diet of Ivory Gulls (Pagophila eburnea) in the North Water

Ivory gulls (Pagophila eburnea, Phipps, 1774), one of the world’s least-known species, have declined throughout their range in recent years. This study describes the patterns of ivory gull use of the North Water polynya, a large polynya that occurs every year near ivory gull breeding sites on Ellesmere Island, Nunavut, Canada. We conducted at-sea surveys from Canadian icebreakers during the summers of 1997–99. In 1998, stomach contents of five ivory gulls were analyzed. We measured stable isotope ratios (d13C, d15N) of liver, muscle, feather and bone to determine how ivory gull diets vary during the year. We observed a total of 275 individuals, most of which were seen on the western side of the polynya. Flying was the predominant behavior (76% of individuals); other behaviors included sitting on ice, sitting on water, and feeding. Four juveniles were seen in August and September. Birds collected had arctic cod (Boreogadus saida) in their stomachs. Other food items included an otolith from an unidentified species of Liparid fish and two bones from a mole, presumed to be a star-nosed mole (Condylura cristata). Stable isotope results indicated that ivory gull trophic levels (TLs) were high (around TL 4 based on d15N) but varied over the season. From the three individuals whose feathers were analyzed, we conclude that differences among individuals in their winter diets or foraging locations are possible.Les mouettes blanches (Pagophila eburnea), soit l’une des espèces les moins connues dans le monde, ont enregistré un déclin à travers l’ensemble de leurs habitats ces dernières années. Cette étude décrit les habitudes des mouettes blanches dans la polynie des eaux du Nord, une grande polynie qui se développe chaque année près des sites de reproduction de mouettes blanches sur l’île Ellesmere, au Nunavut, Canada. Nous avons effectué des relevés depuis des brise-glace canadiens au cours des étés 1997 à 1999. En 1998, le contenu des estomacs de cinq mouettes blanches a été analysé. Nous avons également mesuré les ratios d’isotopes stables (d13C, d15N) dans les foies, les muscles, les plumages et les os afin de déterminer comment le régime alimentaire des mouettes blanches variait au cours de l’année. Nous avons observé 275 individus, provenant principalement du côté ouest de la Polynie. La majorité (76 %) étaient en vol. Parmi les autres comportements observés, notons la présence d’oiseaux sur la glace, d’oiseaux sur l’eau et d’oiseaux en train de se nourrir. Quatre oiseaux juvéniles ont été repérés en août et en septembre. Les oiseaux capturés avaient de la morue polaire (Boreogadus saida) dans l’estomac. Les autres aliments trouvés comprenaient un otolithe provenant d’une espèce non identifiée de poisson Liparidé, et deux os de taupe, probablement un condylure étoilé (Condylura cristata). L’analyse des isotopes stables indique que les niveaux trophiques (NT) des mouettes blanches étaient élevés (NT 4 environ en fonction de d15N), mais variaient au cours de la saison. À partir des trois individus dont les plumes ont été analysées, nous en avons conclu qu’il est possible qu’il existe des différences entre les régimes d’hiver ou les lieux de nourriture des individus

Convergence of genetic influences in comorbidity

Abstract Background Predisposition to complex diseases is explained in part by genetic variation, and complex diseases are frequently comorbid, consistent with pleiotropic genetic variation influencing comorbidity. Genome Wide Association (GWA) studies typically assess association between SNPs and a single-disease phenotype. Fisher meta-analysis combines evidence of association from single-disease GWA studies, assuming that each study is an independent test of the same hypothesis. The Rank Product (RP) method overcomes limitations posed by Fisher assumptions, though RP was not designed for GWA data. Methods We modified RP to accommodate GWA data, and we call it modRP. Using p-values output from GWA studies, we aggregate evidence for association between SNPs and related phenotypes. To assess significance, RP randomly samples the observed ranks to develop the null distribution of the RP statistic, and then places the observed RPs into the null distribution. ModRP eliminates the effect of linkage disequilibrium and controls for differences in power at tested SNPs, to meet RP assumptions in application to GWA data. Results After validating modRP based on both positive and negative control studies, we searched for pleiotropic influences on comorbid substance use disorders in a novel study, and found two SNPs to be significantly associated with comorbid cocaine, opium, and nicotine dependence. Placing these SNPs into biological context, we developed a protein network modeling the interaction of cocaine, nicotine, and opium with these variants. Conclusions ModRP is a novel approach to identifying pleiotropic genetic influences on comorbid complex diseases. It can be used to assess association for related phenotypes where raw data is unavailable or inappropriate for analysis using other approaches. The method is conceptually simple and produces statistically significant, biologically relevant results.http://deepblue.lib.umich.edu/bitstream/2027.42/112931/1/12859_2012_Article_5068.pd