253puse of red clover in premenopausal breast cancer patients receiving hormonal adjuvant treatment biological and clinical implications from a randomized clinical trial

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Role of the electro-thermo-mechanical multiple coupling on the operation of RF microswitch

A phenomenological approach is proposed to identify some effects occurring within the structure of the microswitch conceived for radio frequency application. This microsystem is operated via a nonlinear electromechanical action imposed by the applied voltage. Unfortunately, it can be affected by residual stress, due to the microfabrication process, therefore axial and flexural behaviors are strongly coupled. This coupling increases the actuation voltage required to achieve the so-called ‘‘pull-in'' condition. Moreover, temperature may strongly affect strain and stress distributions, respectively. Environmental temperature, internal dissipation of material, thermo-elastic and Joule effects play different roles on the microswitch flexural isplacement. Sometimes buckling phenomenon evenly occurs. Literature show that all those issues make difficult an effective computation of ‘‘pull-in'' and ‘‘pull-out'' voltages for evenly distinguishing the origin of some failures detected in operation. Analysis, numerical methods and experiments are applied to an industrial test case to investigate step by step the RF-microswitch operation. Multiple electro-hermomechanical coupling is first modeled to have a preliminary and comprehensive description of the microswitch behavior and of its reliability. ‘‘Pull-in'' and ‘‘pull-out'' tests are then performed to validate the proposed models and to find suitable criteria to design the RF-MEM

JPN Guidelines for the management of acute pancreatitis: treatment of gallstone-induced acute pancreatitis

Gallstones, along with alcohol, are one of the primary etiological factors of acute pancreatitis, and knowledge of the etiology as well as the diagnosis and management of gallstones, is crucial for managing acute pancreatitis. Because of this, evidence regarding the management of gallstone-induced pancreatitis in Japan was collected, and recommendation levels were established by comparing current clinical practices with optimal clinical practices. The JPN Guidelines for managing gallstone-induced acute pancreatitis recommend two procedures: (1) an urgent endoscopic procedure should be performed in patients in whom biliary duct obstruction is suspected and in patients complicated by cholangitis (Recommendation A); and (2) after the attack of gallstone pancreatitis has subsided, a laparoscopic cholecystectomy should be performed during the same hospital stay (Recommendation B)

Forecasting and trading on the VIX futures market: A neural network approach based on open to close returns and coincident indicators

Previous work has highlighted the difficulty of obtaining accurate and economically significant predictions of VIX futures prices. We show that both low prediction errors and a significant amount of profitability can be obtained by using a neural network model to predict VIX futures returns. In particular, we focus on open-to-close returns (OTCRs) and consider intraday trading strategies, taking into account non-lagged exogenous variables that closely reflect the information possessed by traders at the time when they decide to invest. The neural network model with only the most recent exogenous variables (namely, the return on the Indian BSESN index) is superior to an unconstrained specification with ten lagged and coincident regressors, which is actually a form of weak efficiency involving markets of different countries. Moreover, the neural network turns out to be more profitable than either a logistic specification or heterogeneous autoregressive models

Superconvergence of the finite element solutions of the Black–Scholes equation

We investigate the performances of the finite element method in solving the Black-Scholes option pricing model. Such an analysis highlights that, if the finite element method is carried out properly, then the solutions obtained are superconvergent at the boundaries of the finite elements. In particular, this is shown to happen for quadratic and cubic finite elements, and for the pricing of European vanilla and barrier options. To the best of our knowledge, lattice-based approximations of the Black-Scholes model that exhibit nodal superconvergence have never been observed so far, and are somehow unexpected, as the solutions of the associated partial differential problems have various kinds of irregularities. \ua9 2012 Elsevier Inc