シャペロニンGroELの機能発現におけるドメイン構造変化の速度論的解析

鳥取大学博士(工学)thesi

教員養成課程におけるキャリア教育シンポジウム―視野の広い教員養成に向けた実践報告―

text紀要論文 / Departmental Bulletin Paperdepartmental bulletin pape

Events Beyond New Registered Nurses' Expectation and Their Coping

departmental bulletin pape

Observation of a Charmoniumlike State Produced in Association with a J/ in e+e- Annihilation at 10.6 GeV

journal articl

13・6 板成形 : 13.塑性加工

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チタンシートを用いた純鉄と3Y-TZPの無加圧接合

http://ci.nii.ac.jp/naid/110002290710/ | http://ci.nii.ac.jp/naid/110002290710/The pressureless bonding of 3Y-TZP and Fe using Ti sheets ( thickness : 0.5 mm, 0.02 mm) and a bonding agent has been studied. A specimen consisting of 3Y-TZP and Fe between which an agent and Ti sheet is inserted is heat-treated at 900°-1100℃ for a considerable length of time in an Ar stream. To reduce the residual stress upon the interface which is caused from the thermal expansion coefficient difference between 3Y-TZP (α=8.8X10^/℃) and Fe (α=13X10^/℃), the optimum Ti sheet thickness has been found to be 0.5 mm. When bonding is made employing a 0.5 mm- thick Ti, the bonding tensile strength of 20℃/min in Ar has become more than 140 MPa. The mean bonding strength of the specimens has been 50 MPa with the use of a 0.5 mm-thick Ti sheet under quite the same conditions. The structure of the well bonded interface has been found to be as shown below. 3Y-TZP/ Titanium oxides layer ( TiO, Ti_2O)/Ti- rich layer ( Ti with scanty Cu) / Cu- Ti alloy layer ( CuTi_2)/diffusion layer ( CuTi_2 containing Fe)/Fe ( α-Fe) . Utilizing the same method, bonding of 3Y- TZP with Nb, Ta (purity : 99. 9℃) and SUS304 has been carried out by the heat-treatment. With the 0.5 mm-thick Ti sheet, the bonding strength of TZP and Nb/ Th specimen has become more than 105 MPa and 120 MPa, respectively. However, the bonding strength of the 3 Y- TZP and the SUS 304 has been found to be just approximately 30 MPa. Such bonding strength is expected to be furthermore increased in parallel with the raise of the heating rate (20℃/ min) .rights: 社団法人日本セラミックス協会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110002290710/textapplication/pdfjournal articl

異方性と損傷を考慮した皮膚骨の非弾性構成式の定式化

An anisotropic inelastic constitutive model of cortical bone was formulated to predict deformation and failure behavior in traffic accidents or falling by utilizing the framework of viscoplasticity and damage mechanics. The model can represent characteristic features of cortical bone, such as anisotropic elastic coefficients with strain rate dependency, viscoplasticity with strength anisotropy as well as strength asymmetry of tension and compression. The damage evolution equation also enables us to predict bone failure with rate dependency. Experimental data of uniaxial compressive or tensile loading tests of human cortical bone at various strain rates were used to validate the proposed model. Predicted stress-strain curves and failure points agreed well with those of experimental data at wide range of strain rates. This shows the present model can be used to predict bone failure in various impact simulations of traffic accidents or falling.journal articl

肺硬化性血管腫の1手術例

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Mechanism of Activation of PGE₂ Synthesis at the Onset of LPS Fever in Rats

<p>Tissue contents of the following proteins are shown: IκB-α (an inhibitor of nuclear factor-κB), three PGE₂-synthesizing enzymes (p-cPLA₂, COX-2, and mPGES-1), and β-actin (a “housekeeping” protein). These proteins were determined by Western blot in the lung, liver, and hypothalamus. The tissue samples were collected 40 min after i.v. injection of LPS (10 μg/kg) or saline at thermoneutrality. This time point corresponds to the maximal thermoeffector activity to produce the first phase of LPS fever (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0040284#pbio-0040284-g001" target="_blank">Figure 1</a>B). Electrophoretograms of two representative animals from each group are shown on top. The expression of each protein of interest (relative to the expression of β-actin) is shown on bottom (means ± SE); the number of rats <i>(n)</i> is shown in parenthesis. An asterisk (*) indicates a significant difference from the saline-treated group (<i>p</i> < 0.05; Student <i>t</i>-test).</p

Circulating PGE₂ Initiates LPS Fever in Rats: Circumstantial Evidence

<div><p>(A) The effects of i.v. infusion (horizontal bar) of BSA-bound PGE₂ or BSA on T_c and heat loss index of rats kept at a neutral ambient temperature (30 °C).</p> <p>(B) The effects of i.v. bolus injection (arrow) of LPS or saline on the same parameters.</p> <p>Change in T_c was calculated by subtracting the T_c value at a given point from that at the start of infusion or injection (time zero). In (A), the absolute T_cs at time zero were 38.3 ± 0.1 °C, 38.5 ± 0.1 °C, and 38.4 ± 0.2 °C for the groups treated with BSA and with the lower and higher doses of BSA-bound PGE₂, respectively. In (B), initial T_cs were 38.2 ± 0.1 °C and 38.3 ± 0.1 °C for the groups treated with saline and LPS, respectively. The heat loss index was calculated as a quotient of two temperature gradients: skin-ambient and colonic-ambient; this index varies between 0 (maximal vasoconstriction) and 1 (maximal vasodilation) [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0040284#pbio-0040284-b033" target="_blank">33</a>].</p> <p>(C) The levels of PGE₂ in the venous and arterial blood of rats 40 min after i.v. injection of LPS or saline at thermoneutrality. This time point corresponds to the maximal thermoeffector activity (minimal heat loss index) to produce the first phase of LPS fever as shown in (B). All doses are indicated. Means ± SE are presented. The number of rats in each group <i>(n)</i> is indicated. An asterisk (*) indicates a significant difference from the BSA- or saline-treated group (<i>p</i> < 0.05; two-way analysis of variance for repeated measures followed by the Tukey test in [A] and [B]; Student <i>t</i>-test in [C]).</p></div