소아에서 신체활동 시간과 대사이상 군집의 관계 : 대체모형 분석을 이용하여

학위논문(석사) --서울대학교 대학원 :보건학과(보건통계학전공),2008. 8.Maste

Study on a fictitious domain method for elliptic problems

학위논문(석사)--亞洲大學校 大學院 :數學科,2001Maste

tDCS 자극에 의한 OFC 영역의 활성이 경제적 및 사회적 보상에 기초한 의사결정에 미치는 영향

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2016.8 ,[iv, 48 p. :]Decision making based on reward has attracted the attention of researchers, and considerable progress has been made in understanding its neural basis. In the present study, reward processing were divided into two different types of reward, economic and social decision making. There is only few research to compare encoding two different reward and investigate the behaviors in identical condition. Understanding how people behave in conflict situation between economic and social decision making is important. Orbitofrontal cortex (OFC) is one of brain regions to encode reward value in reward processing. Several human neuroimaging studied are shown that activity in the OFC correlates with behavioral measures of reward magnitude for the monetary and social reward modalities. In this study, we designed an experiment paradigm aiming to investigate changing reward based decision making after modulation over the OFC by transcranial direct current stimulation (tDCS). We used incentive delay task to quantify to monetary and social reward sensitivity, and investigated conflict situation between monetary and social reward in trust game. Also to identify stimulating to the OFC enough, we conducted Stroop Color word task. From the result in baseline study, there is no difference in reward and punishment sensitivity in each of monetary and social stimuli. In conflict situation between monetary and social reward, people who are more concerning other people returned more money. People who are more sociable in conflict situation may have higher social reward sensitivity. There was no significant change in reward sensitivity. Active tDCS applied over the OFC did not influence with overall return rate. Participants are divided into two types (showing increased return rate and decreased return rate) because the OFC is related to both monetary and social reward processing. People who are changed to be social after tDCS to the right OFC are more sensitive to social reward and punishment. It indicated that the right OFC is significantly associated with social reward based decision making. Our experimental results showed that participants receiving anodal tDCS over the OFC have higher monetary sensitivity when they care money more than social reward in limited resource condition. It suggested that the right OFC is significantly associate brain region with social reward based decision making, and both right and left OFC is related to monetary reward based decision making. Our results support the notion that the OFC plays an important role in reward processing.한국과학기술원 :바이오및뇌공학과

Expression of HuR in the Head and Neck Squamous Cell Carcinoma

The human ELAV(embryonic lethal abnormal vision)-like protein HuR stabilizes a certain group of cellular mRNAs that contain AU-rich elements in their 3'-untranslated region. To test the significance of HuR in carcinogenesis of head and neck squamous cell carcinomas(HNSCCs), we have investigated HuR expression from 32 benign epithelial lesions, 14 premalignant epithelial lesions and 80 HNSCCs. There were two different staining patterns of HuR in HNSCCs: nuclear expression was seen in 78.7% (63 of 80) of cases; and an additional cytoplasmic expression was seen in 28.7%(23 of 80) of cases. Nuclear expression of HuR was significantly increased in premalignant lesions and HNSCCs, whereas increased cytoplasmic expression of HuR was only observed in HNSCCs. Cytoplasmic HuR expression was significantly increased in patients of HNSCC younger than 60 years. Although there was no significant correlation between anatomic sites of HNSCCs and HuR expression, cytoplasmic HuR expression was highly increased in HNSCCs of larynx. There was no significant correlation between HuR expression and other clinicopathological parameters such as histological type, tumor size, or nodal status. In conclusion, this study suggests that overexpression of HuR in HNSCCs may be part of a regulatory pathway that controls the mRNA stability of several important targets in carcinogenesis of HNSCCs.N