Histopathological findings and clinical effects for acute rejections

国際Banff基準と治療効果には相関を認めた.G2以上の症例には, OKT3及びALGがMPに比べ, 有効率に有意差を認めた.DSGは症例数が少なく, 今後の検討が必要であるWe reviewed 115 cases of acute rejection following renal transplantation. All cases were diagnosed after graft biopsy, and showed histopathological evidence of acute rejection. They were treated with administration of OKT3, 15-deoxyspergualin (DSG), anti-lymphocyte globulin (ALG) or methylprednisolone (MP). All rejections were histopathologically classified according to the Banff working classification. The clinical effects of each drug were evaluated both at 1 month and 1 year following the therapy for rejection, by measurement of serum creatinine level. The effective rate both at 1 month and 1 year was related with the Banff working classification ( p < 0.0001). At 1 month after treatment, there were no significant differences between the OKT3, DSG or ALG group and MP group in cases of borderline change and AR grade I. In cases of grade II and grade III, a significant difference was observed between the OKT3 or ALG group and MP group (p < 0.05). The DSG group showed a slightly better outcome than the MP group, although the difference was not significant. In conclusion, the Banff schema is shown to be valid for classification of acute renal allograft rejection, and it is necessary to determine the treatment for acute rejection according to histopathological classification

Comprehensive review of cell therapy for central nervous system disease in China

A recent breakthrough in cell therapy is expected to reverse the neurological sequelae of stroke, spinal cord injury, traumatic brain injury and so forth. In fact, various clinical trials concerning cell therapy for central nervous system (CNS) disease have been reported all over the world. Although some pioneer studies were conducted in China, accurate information was not always conveyed to Japan due to the language barrier. In our present article, we reported our systematic review of the scientific papers and the protocols about clinical trials concerning cell therapy for CNS disease in China. Moreover, we reported the regulatory framework for the stem cell research in China. It is noteworthy that we referred to not only English-based databases, but also Chinese-based databases. In conclusion, though some problems remain in China, we expect the acceleration of cell therapy for CNS disease in the future because of the new regulatory framework

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出處：輔仁大

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出處：世新大

EFFECTS OF STIFFNESS ON THE CHARACTERISTICS OF STEADY FLUID-STRUCTURE INTERACTIONS OF AN AIRSHIP

飞艇作为临近空间高分辨率观测的重要平台,力学性能研究非常重要。飞艇的主体材料一般由柔性蒙皮构成,容易在气动作用下产生较大的变形,存在较强的流固耦合效应,是其力学性能研究的关键。该文采用松耦合方法形成了定常流固耦合计算方法,并且针对流场与结构的模型展开了详细的计算,和实验结果进行了验证。针对不同刚度构型飞艇模型的计算结果显示:硬式飞艇不需考虑流场和结构的耦合效应,半硬式和软式飞艇的耦合效应较明显。其中半硬式飞艇,耦合效应主要影响区域为柔性最大的橡胶部分,考虑耦合效应后,飞艇位移变形量增加约5%。软式飞艇,变形最为明显的是飞艇的尾部和头部,在来流作用下会出现明显的抬头位移,最大位移增量为225%。此外还采用量纲分析方法,得到了艇体变形与膜材料弹性模量、内压、来流的变化规律。当模型与实物满足几何相似、材料相似和动力学相似的条件下,变形将满足几何相似律