Comparative double-blind trial of KN-7 tablet and Robaveron injection in the treatment of neurogenic bladder

37施設で, 神経因性膀胱233例を対象に, ロバベロン注射剤を標準薬とし, KN-7錠剤の経口投与による排尿障害に対する有用性を, 二重盲検群間比較試験で比較検討した.解析対象例はKN-7群108例, ロバベロン群107例である.KN-7群は1日6錠投与した.改善度の効果判定では改善以上K群40.7%, R群38.7%, やゝ改善以上それぞれ76.9%, 72.6%と有意差はなかった.臨床所見中改善の良かった項目は, 尿意, 残尿感, 尿失禁, 排尿までの時間, 排尿時間, 尿勢-排尿力と尿線中断の改善などで, これらの改善以上はK群35.8%, R群30.8%で, 有意差はなかった.副作用はK群0.9%, R群6.8%, K群が有意に少なかった.両剤とも主として下痢で, R群ではその他頭痛, 頻脈, 肝機能障害, 発熱感などを少数例認めた.臨床検査値ではGOT, GPTの上昇が2例あった.有用度有用以上はK群46.3%, R群45.8%で有意差はなかった.疾患別では, 末梢神経疾患, 膀胱の性状では弛緩性, 時期では12ヵ月以内の例で特に改善率が高かった.以上から, KN-7錠剤は, ロバベロン注射剤に比べ, 同等の効果が期待でき, 安全性も高く, 長期投与あるいは外来患者の治療にも適するThe clinical effectiveness, safety and usefulness of KN-7 tablet as a new oral application of the prostatic extract, on urinary dysfunction of neurogenic bladder were compared with those of Robaveron injection by the double-blind test method. In the study, 2 tablets t.i.d. and a shot of intramuscular injection 1 ml a day were given successively for 3 weeks. A total of 233 cases were reported from 37 facilities belonging to the KN-7 Clinical Research Group. Some of them were excluded or dropped out. The number of cases used for analysing the effectiveness, safety and usefulness were 214, 232 and 215, respectively. There was no bias between the two groups with a significant homogeneity in the background. In the overall clinical effectiveness, the effective rate including excellent, moderate and slightly effective was 76.9% with KN-7 and 77.4% with Robaveron. In the clinical usefulness, the rate of usefulness of slightly useful or above was 75.0% with KN-7 and 75.7% with Robaveron. There was no significant difference between the two groups in the clinical effective and useful rates at a significant level of 5%. Side effects were observed in 1 of the 114 (0.9%) patients given KN-7 and 8 of the 118 (6.8%) patients given Robaveron. The incidence of adverse reactions with KN-7 was significantly lower than that with Robaveron. Based on the results, it was concluded that KN-7 tablets, 2 tablets t.i.d., would be as effective and useful as a Robaveron injection 1 ml daily and safer than the latter in the treatment of neurogenic bladder

Observation results by the TAMA300 detector on gravitational wave bursts from stellar-core collapses

We present data-analysis schemes and results of observations with the TAMA300 gravitational-wave detector, targeting burst signals from stellar-core collapse events. In analyses for burst gravitational waves, the detection and fake-reduction schemes are different from well-investigated ones for a chirp-wave analysis, because precise waveform templates are not available. We used an excess-power filter for the extraction of gravitational-wave candidates, and developed two methods for the reduction of fake events caused by non-stationary noises of the detector. These analysis schemes were applied to real data from the TAMA300 interferometric gravitational wave detector. As a result, fake events were reduced by a factor of about 1000 in the best cases. The resultant event candidates were interpreted from an astronomical viewpoint. We set an upper limit of 2.2x10^3 events/sec on the burst gravitational-wave event rate in our Galaxy with a confidence level of 90%. This work sets a milestone and prospects on the search for burst gravitational waves, by establishing an analysis scheme for the observation data from an interferometric gravitational wave detector

大型ヘリカル装置のIC聾アンテナと加熱特性

Ion－cyclotron heating was applied to the Large Helical Device by using single, trap loop antennas located at the outward side of the toroid. Good experimental results were obtaine with adequate plasma　confining configurations and antenna conditionings．Loading resistance of the antenna was2－8Ohm and　this was a sufficiently large value. Various heating characteristics were investigated by changing the　heating modes, ion species and magneticfield configurations．The minoriy-ion heating mode resulted in the best heating performances，and the heatin gcharacteristics largely depended on the cyclotron resonance positions．There were some unique features due to the heliotron configuration．These results showed the　effectiveness of the ICRF heating in a helical device and the appropriateness of the ICRF antenna design　in the LHD

Fourteen cases of the non-Hodgkin\u27s lymphoma in the last 8 years

悪性リンパ腫は, リンパ球性細胞ないしは細網内皮系細胞に由来する腫瘍で, 全身各所のリンパ節, リンパ性組織の存在する部位より生じるとされている。今回私達は, 昭和50年11月から昭和58年10月までの8年間に病理組織学的に非ホジキン悪性リンパ腫と診断された14例について臨床的検討を加えた。性別は, 男性10例, 女性4例で, 年齢別では40歳台が最も多く, 14例中11例が40歳以上であった。初発部位は顎下リンパ節4例, 頬部3例, 上顎歯肉歯槽部2例, 舌根・扁桃部1例, 耳下腺部1例であった。初診時臨床所見では, 全例に罹患部の腫脹が認められ, 次いで, 頸部リンパ節腫脹, 知覚異常, 歯の動揺が多くみられた。病理組織学的には, LSG分類^1)によればDiffuse Lymphoma10例, Folicular Lymphoma3例で残り1例は, 壊死が著しく分類下能であった。治療は, 主に放射線療法と化学療法が併用され, 線量は30～114Gyの広範囲に及んでおり, 化学療法はVQFP療法が中心であった。予後に関しては, 追跡調査が可能であった12例中, 死亡例が7例で残り5例は初診から最長7年を経過した症例も含め現在当科外来にて経過観察中である