The effect of inflammatory cytokines and the level of vitamin D on prognosis in Crimean-Congo hemorrhagic fever

ERTURK, AYSE/0000-0001-6413-9165WOS: 000367669800140PubMed: 26770432Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease. Its pathogenesis basically involves endothelial damage. the aim of this study was to determine serum IL2, IL6, IL 10 and 25 OH Vitamin D levels in patients with CCHF and also to reveal their role in the clinical course and prognosis of the disease. Diagnosis of CCHF was confirmed using the positive polymerase chain reaction (PCR) test and/or positive IgM antibody by enzyme-linked immunosorbent assay (ELISA). Serum IL-2, IL-6, IL-10 and total 25 OH Vitamin D levels were also measured using ELISA. Eighty CCHF patients and 110 healthy controls were enrolled. IL2, IL6 and IL10 levels were significantly higher in the patient group. IL 6 and IL 10 levels were significantly higher in the fatal group. There was a positive correlation between Vitamin D and AST (r = 0.402; P < 0.001), and another positive correlation between IL-6 and CK (r = 0.714; P < 0.001). High IL6 and L10 levels are a significant indicator of fatality. Cytokines are only one of the factors responsible for mortality. We conclude that the pathogenesis of the disease can be better understood by elucidating the complicated cytokine network.Ataturk University Scientific Research Projects CommissionAtaturk University [2012-24]We thank Dr. Yasemin Cayir for advice on statistical analysis; Dr. Hulya Aksoy for assistance with development of biochemical outcome measures. This study was supported by the Ataturk University Scientific Research Projects Commission (Project No. 2012-24)

Effect of Origanum dubium, Origanum vulgare subsp. hirtum, and Lavandula angustifolia essential oils on lipid profiles and liver biomarkers in athletes

WOS:000744122600001PubMed ID34496170This study aims to determine the effects of essential oils of Origanum dubium (DUB), Origanum vulgare subsp. hirtum (HIR), and Lavandula angustifolia (LAV) on lipid profiles and liver biomarkers in athletes. Thirty-four trained athletes were randomly assigned to one of three experimental groups or the control group (CON). The concentrations of serum lipids and liver biomarkers were assessed before and after the 14-day essential oil intervention. Gas chromatography-mass spectrometry analysis showed 68.0 and 82.1% carvacrol in DUB and HIR, respectively, and 34.50% linalyl acetate and 33.68% linalool in LAV essential oils. One-way analysis of covariance (ANCOVA) indicated a significant difference (p = 0.001) among the groups for high-density lipoprotein cholesterol (HDL-C) when the associated preintervention values were used as a covariate. The related pairwise comparisons revealed that DUB (p = 0.001) and HIR (p = 0.024) had greater HDL-C values than CON. From the two-way ANOVA, an interaction between time (before vs. after) and the groups (DUB vs. HIR vs. LAV vs. CON) was found for HDL-C (p = 0.030). Findings indicated a significant increase in DUB (p = 0.0001) and HIR (p = 0.010) for HDL-C, and there was a significant decrease in DUB (p = 0.023) for low-density lipoprotein cholesterol. However, there was no difference in total cholesterol, triglycerides, and all liver biomarkers

Akut Apandisit Hastalarında Ghrelin Hormon Düzeyi Bakılması ve Ghrelin Hormon Düzeyinin C-Reaktif Protein ve Beyaz Kan Hücre Düzeyleri İle Karşılaştırılması

Amaç: Bu çalışmada akut apandisit hastalarında ghrelin hormonunun tanısal değerininin incelenmesi ve white blood cell (WBC), c-reaktif protein (CRP) gibi rutin kullanılan laboratuvar testleriyle korelasyonunun değerlendirilmesi amaçlanmıştır. Yöntem: Ekim 2018 ile Aralık 2018 tarihleri arasında akut apandisit ön tanısı ile ameliyat edilen 16-80 yaş arası hastalar prospektif olarak incelendi. Preoperatif dönemde hastalardan hemogram ve CRP ile birlikte ghrelin hormon düzeyi ölçümü için kan alındı. Hastalar 3 gruba ayrılarak yaş, cinsiyet, ek hastalık, iştahsızlık, ghrelin, lökosit, CRP ve vücut kitle indeksi (VKİ) gibi parametreler karşılaştırıldı. Bulgular: Çalışmaya 30 sağlıklı kişi, 29 nonkomplike apandisit, 29 komplike apandisit olarak 3 grup dahil edildi. Gruplar arasında yaş, cinsiyet, VKİ ve ghrelin düzeyleri arasında anlamlı fark saptanmadı (p&gt;0.05). İştahsızlık, Lökosit ve CRP düzeyleri akut apandisitli hastalarda kontrol grubuna göre ileri derecede anlamlı saptandı (p&lt;0,001). Hastaların ghrelin değerlerinin lökosit ile korelasyonuna bakıldığında anlamlı bir korelasyon saptanmadı. Sonuç: Akut apandisit tansında ve hastalığın ciddiyetinin belirlenmesinde WBC ve CRP gibi serolojik testler kullanılabilir. Akut apandisitin ciddiyet düzeyi arttıkça ghrelin hormon değeri de artmaktadır ancak gruplar arasında anlamlı bir fark saptanmadı. Akut apandisit gibi iştah düzeyinin değiştiği bir hastalık için, daha fazla hasta katılımının olduğu çok merkezli çalışmalara ihtiyaç vardır

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in the Emergency Department

Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor(urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed onvarious cell types. Previous literature shows that the amount of soluble urokinase-typeplasminogen activator receptor (suPAR) secreted from affected cells is higher in Crimean-Congohemorrhagic fever (CCHF) patients than in healthy controls. Thus, we aimed to investigate thediagnostic value of suPAR in the differential diagnosis of CCHF in emergency services.Material and Methods: Individuals over 16 years old with a preliminary diagnosis of CCHFdisease were divided into two groups as real time-polymerase chain reaction (RT-PCR) and/orIgM positive (CCHF group) and RT-PCR and/or IgM negative (control group).Results: Eighty patients were included in this study. Forty patients with CCHF virus PCRand/or CCHF virus IgM were identified as CCHF group and 40 patients included as negativecontrol group. The median age of the patients was 45 (range, 16-91) years, and 49 patients(61.3%) were male. Leukocyte, platelet, and fibrinogen levels were significantly lower, whilecreatinine kinase, aPTT, and D-dimer levels were significantly higher in CCHF group. Therewas no statistically significant difference between the control group and CCHF group forSuPAR (p=0.386). In addition, control group patients not diagnosed with CCHF wereexamined, brucellosis, influenza, and pneumonia were found to be the most common.Conclusion: The use of suPAR as a biomarker in the differentiation of patients with similarfindings in emergency services was investigated and found to have no diagnostic value

An Analysis on Coronary Artery Disease Severity with Serum Adropin Level in Patients with Acute ST-Segment Elevation Myocardial Infarction

Objective Adropin is associated with energy balance in tissues and organs. The SYNTAX score (SS) is used to determine the severity of ST-segment elevation myocardial infarction(STEMI). The aim of this study was to determine the relationship between serum adropin levels and disease severity in STEMI patients.Materialsand MethodsEighty-nine patients who underwent coronary angiography (CAG) for STEMI were included in the study. The STEMI patients were divided into two subgroups: Group 1(SS< 22) and Group 2 (SS ≥ 23). 43 patients who underwent CAG and had normal coronary arteries were included in the study as a control group.Results Groups 1 and 2 included more male participants than the control group (89.7% and 74.2% vs. 34.9%, respectively, p < 0.001). The smoking rate was higher in Groups 1 and2 than in the control group (55.1% and 34.4% vs. 11.6%, respectively, p≤0.001). Serum adropin levels were lower in Group 1 than in the control group (147.3 ± 149.2 mg/Land 228.1 ± 253.3 ng/L, p = 0.03). Serum adropin levels were the lowest in Group 2 (87.8 ± 23.2 ng/L, 147.3 ± 149.2 ng/L, and 228.1 ± 253.3 ng/L, p = 0.004). Serum adropinlevels were also negatively correlated with SS (r = -0.33, p = 0.002).Conclusion Serum adropin levels decreased more in STEMI patients than in those without coronary artery disease (CAD). In addition, serum adropin levels decreased with increasingSS;this indicates the severity of CAD