Okul öncesi 4-6 yaş çocuklarında algısal motor gelişim programlarının denge ve çabukluk üzerine etkisi

Preschool is the term that allows the most positive and permanent contributions to movements skills to be realized. This term includes the development stages that may shape whole life. It is known that, apporpriate education programs in sensitive age terms accelerate development at children. Therefore, the effects of perceptual motor development programs on balance and qucikness will be examined in this study.Pre-test Post-test control group model is carried out  in this study. 62 children, consisting of 30 for test group and 32 for control gorup and ages of which changing between 4 and 6 were participated in this study. Perceptual motor development activities were applied on test group for a period of 14 weeks and pre-test and post-test differences were analized by independent samples t test between the groups. Consequently; while significant differences (p<0.01) were seen at within-group measurements, there was no significant difference at between-group measurements (p>0.05) at the pre-test post test values of motor performance of test group and control gorup.Okul öncesi, hareket becerisine en olumlu ve kalıcı katkıların yapılabileceği bir dönemdir. Bu dönem tüm yaşama yön verebilecek gelişim aşamalarını kapsar. Duyarlı yaş devrelerinde uygun eğitim programlarının çocuğun gelişimini hızlandırdığı bilinmektedir. Buradan hareketle, bu çalışmada algısal motor gelişim programlarının, denge ve çabukluk üzerine etkisinin incelenmesi amaçlanmıştır. Bu araştırmada ön-test son-test kontrol gruplu model uygulanmıştır Çalışmaya; 4 ile 6 yaş arasında değişen, 30 deney, 32 kontrol grubu olmak üzere toplam 62 çocuk katılmıştır. Deney gurubu için 14 hafta süreyle algısal motor gelişim aktiviteleri uygulanmış ve gruplar arasındaki ön-test son-test farklılıkları bağımsız grup t testi ile incelenmiştir. Araştırmanın sonunda; deney ve kontrol grubunun ön-test son-test motor performans değerlerinde, grup içi ölçümlerde anlamlı farklılıklar görülürken (p<0.01), gruplar arası ölçüm değerlerinde herhangi bir anlamlı farklılık bulunmamıştır (p>0.05)

Effect of Pink Rock Rose Extract with or Without Ascorbic Acid and Sodium Ascorbate for the Preservation of Ready-to-Eat Frankfurter Type Sausages

This study aimed to determine the effect of pink rock rose extract (PRR) with or without ascorbic acid and sodium ascorbate for improving the shelf life of sausages. Analyzed parameters were DPPH radical scavenging capacity of PRR extract; total aerobic count, thiobarbituric acid reactive substance, heme iron, pH, water activity, proximate composition, and color values of MAP packaged sausages for 12 weeks at 4 °C. Treatments: (1) Control (0.02% ascorbic acid and 0.05% sodium ascorbate – AA-SA), (2) electrostatic spray application of PRR extract (2%) – ES-PRR, (3) 0.02% AA and, 0.05% PRR extract, (4) 0.05% SA and 0.02% PRR, (5) 0.07% PRR extract. PRR extract had the half maximal inhibitory concentration (IC50) value of 13.04 ± 0.133 µg/mL. Sausages formulated with 0.07% PRR had the lowest microbial growth rate, followed by AA-PRR formulation. The AA-PRR treatment had the lowest TBARS values for most of the storage. This study reveals that PRR extract can be added as a natural antioxidant in sausages, and it could be used as a replacement or for the reduction of ascorbic acid and sodium ascorbate in sausage formulations

Evaluation of Leukemia and Solid Tumors in Refugee Children in Turkey: A Tertiary Center Experience

Cancer care is progressively became as a significant worldwide challenge. Wars can cause destructions and delays in cancer diagnosis and treatment of displaced people. Cancer cure rates need to be improved in indefensible populations such as refugees. In this study, we purposed to highlight the clinical peculiarities and outcomes of refugee children with cancer in our hospital. Our purpose was to present our findings and contribute to improve the health care for these children. Seventy one refugee pediatric patients admitted to the oncology and hematology units of our hospital between April 2011 and January 2019 were included in this study. The demographic characteristics of the patients at the initial diagnosis, their countries of origin, living conditions, histopathological diagnoses, treatments, relapse, and mortality data were analyzed retrospectively from the patient files. The median age of patients was 6.5±4.5 years, and the male-to-female ratio was 39/32. While 44 patients (61.9%) presented with complaints and had primary diagnoses in our hospital, the remaining 27 patients (38.1%) were diagnosed in their country and applied to our hospital for treatment. Our mean follow-up period was 18.2±18.8 months (1-90 months). As a result, 44 patients (62%) were alive and 22 (31%) were dead. The survival rate without relapse in the second year was 83.6%. Two and fiveyear survival rates were 77.5% vs. 58.1% respectively. Compared to Turkish children, lower survival rates were found in refugee children. In addition to cancer-specific factors such as tumor type and stage, some problems such as shelter, communication, adherence to treatment, and difficulties supplying medicine may be responsible for lower survival rates in refugee children. Further studies are needed to improve the survival rates of patients

NEPHROTOXICITY OF GENTAMICIN AND COTRIMOXAZOLE COMBINATION IN RATS

1. The nephrotoxicity of gentamicin is well known. However, little information is available regarding the combined effects of gentamicin plus co-trimoxazole (sulfamethoxazole-trimethoprim). Therefore, Wistar rats were treated daily with 100 mg/kg gentamicin or 100 mg/kg gentamicin plus 30 mg/kg trimethoprim-150 mg/kg sulfamethoxazole for 14 days. 2. Serum biochemical parameters were measured on days 0, 8 and 15, and histopathological examinations of kidneys were performed on day 15, one day following end of treatment. Gentamicin treated rats exhibited a 63% increase in blood urea nitrogen (BUN), a 124% increase in uric acid, and a 63% decrease in serum potassium levels on day 15. 3. The combination of gentamicin plus co-trimoxazole partially ameliorated these effects. With the three drug combination no change occurred in BUN, and only a 30% decrease occurred in serum potassium levels. 4. While serum creatinine levels significantly increased following gentamicin, the co-administration of co-trimoxazole resulted in a significant decrease (30%) in creatinine. Histopathological examinations of kidneys suggested a lower degree of nephrotoxicity in rats treated with gentamicin plus co-trimoxazole as compared to animals treated with gentamicin alone. 5. The results support the importance of monitoring serum biochemical parameters when treating with gentamicin or gentamicin plus co-trimoxazole

A cross-sectional study in patients with pre-dialysis chronic kidney disease: Quality of life and related factors

AMAÇ: Kronik Böbrek Hastalığı (KBH) insidansı ve prevalansı tüm dünyada artmaktadır. KBH’da sıklıkla komplikasyonlar fazladır ve kötü yaşam kalitesi ile birliktedir. Bu çalışmanın amacı Kısa form-36 (SF-36) ölçeği ile KBH’da yaşam kalitesinin değerlendirilmesi ve böbrek fonksiyonları, yaş, cinsiyet, eğitim düzeyi, sosyo ekonomik durum, hemoglobin, albumin, HBA1c, 25OHvitamin D düzeyinin yaşam kalitesi üzerindeki etkisinin araştırılmasıdır. GEREÇ VE YÖNTEM: Bu kesitsel çalışma Antalya Eğitim ve Araştırma Hastanesinde takipli 211 KBH tanılı hastada (ortalama yaş 56 ± 13 yıl), Ocak-Haziran 2016 tarihleri arasında yapıldı. Hastaların yaşam kalitesini saptamak için SF-36 ölçeği kullanıldı ve laboratuvar testleri, klinik ve demografik verileri kayıt edildi. BULGULAR: KBH-EPI formülü kullanılarak hastalar KBH evrelerine ayrıldı. Hastaların %59,2’si Evre 1-3, %40,8’i Evre 4-5 olarak saptandı. Evre 4-5 hastalarda fiziksel rol güçlüğü skoru daha düşük saptandı. Yaşın yaşam kalitesini negatif etkilediği görüldü. Hemoglobin, albumin ve 25 OH vitamin D düzeylerindeki artışın fiziksel fonksiyon ve fiziksel rol güçlüğü skorlarında artışla birlikte olduğu saptandı. Artmış HbA1C düzeylerinin kötü fiziksel fonksiyon skoruyla ilişkili olduğu görüldü. Eğitim düzeyi ,sosyo ekonomik durum ile yaşam kalitesi arasında ilişki saptandı. SONUÇ: KBH tanılı hastada böbrek fonksiyonları, yaş, cinsiyet, eğitim düzeyi ve sosyoekonomik durum yaşam kalitesini etkilemektedir. KBH’da yaşam kalitesini artırmak için; hemoglobin, albumin, HbA1c ve 25 OH vitamin D düzeyleri gibi değiştirebileceğimiz faktörleri iyileştirmeliyiz.OBJECTIVE: The incidence and prevalence of patients with chronic kidney disease (CKD) is increasing worldwide. It is often associated with a high prevalence of complications and worse quality of life. The main objective of this study is to evaluate quality of life (QOL) using the generic instrument short form-36 (SF-36) in patients with CKD and identify the possible influence of the degree of renal function, age, gender, education level, socioeconomic status, hemoglobin, albumin, HbA1c and 25 hydroxy vitamin D level on QOL. MATERIALS AND METHODS: For this cross-sectional study, we included 211 CKD patients ( median age 56 ± 13 years) admitted to the outpatient clinic of Antalya Research and Training Hospital Nephrology Unit between January and June 2016. Participants completed the short form-36 health survey (SF-36). Laboratory tests and clinical and demographic data were obtained. RESULTS: The patients were classified into CKD stages according to the CKD-EPI equation: 59,2% were in CKD Stage 1-3 and 40,8% were in Stage 4-5. The patients in Stage 4-5 had lower scores in physical aspects. Age influence QOL negatively. CKD patients with higher hemoglobin, albumin and 25 hydroxy vitamin D levels has better functional capacity and physical aspects. High HbA1c levels significantly associated with bad functional capacity. Education level and socioeconomic status is associated with QOL. CONCLUSIONS: Renal function, age, gender, education level and socioeconomic status influenced QOL. To imrove QOL in CKD patients we need to focus on factors that can be changed, such as improving the hemoglobin, albumin, HbA1c and 25 hydroxy vitamin D levels

A cross-sectional study in patients with pre-dialysis chronic kidney disease: Quality of life and related factors

AMAÇ: Kronik Böbrek Hastalığı (KBH) insidansı ve prevalansı tüm dünyada artmaktadır. KBH’da sıklıkla komplikasyonlar fazladır ve kötü yaşam kalitesi ile birliktedir. Bu çalışmanın amacı Kısa form-36 (SF-36) ölçeği ile KBH’da yaşam kalitesinin değerlendirilmesi ve böbrek fonksiyonları, yaş, cinsiyet, eğitim düzeyi, sosyo ekonomik durum, hemoglobin, albumin, HBA1c, 25OHvitamin D düzeyinin yaşam kalitesi üzerindeki etkisinin araştırılmasıdır. GEREÇ VE YÖNTEM: Bu kesitsel çalışma Antalya Eğitim ve Araştırma Hastanesinde takipli 211 KBH tanılı hastada (ortalama yaş 56 ± 13 yıl), Ocak-Haziran 2016 tarihleri arasında yapıldı. Hastaların yaşam kalitesini saptamak için SF-36 ölçeği kullanıldı ve laboratuvar testleri, klinik ve demografik verileri kayıt edildi. BULGULAR: KBH-EPI formülü kullanılarak hastalar KBH evrelerine ayrıldı. Hastaların %59,2’si Evre 1-3, %40,8’i Evre 4-5 olarak saptandı. Evre 4-5 hastalarda fiziksel rol güçlüğü skoru daha düşük saptandı. Yaşın yaşam kalitesini negatif etkilediği görüldü. Hemoglobin, albumin ve 25 OH vitamin D düzeylerindeki artışın fiziksel fonksiyon ve fiziksel rol güçlüğü skorlarında artışla birlikte olduğu saptandı. Artmış HbA1C düzeylerinin kötü fiziksel fonksiyon skoruyla ilişkili olduğu görüldü. Eğitim düzeyi ,sosyo ekonomik durum ile yaşam kalitesi arasında ilişki saptandı. SONUÇ: KBH tanılı hastada böbrek fonksiyonları, yaş, cinsiyet, eğitim düzeyi ve sosyoekonomik durum yaşam kalitesini etkilemektedir. KBH’da yaşam kalitesini artırmak için; hemoglobin, albumin, HbA1c ve 25 OH vitamin D düzeyleri gibi değiştirebileceğimiz faktörleri iyileştirmeliyiz.OBJECTIVE: The incidence and prevalence of patients with chronic kidney disease (CKD) is increasing worldwide. It is often associated with a high prevalence of complications and worse quality of life. The main objective of this study is to evaluate quality of life (QOL) using the generic instrument short form-36 (SF-36) in patients with CKD and identify the possible influence of the degree of renal function, age, gender, education level, socioeconomic status, hemoglobin, albumin, HbA1c and 25 hydroxy vitamin D level on QOL. MATERIALS AND METHODS: For this cross-sectional study, we included 211 CKD patients ( median age 56 ± 13 years) admitted to the outpatient clinic of Antalya Research and Training Hospital Nephrology Unit between January and June 2016. Participants completed the short form-36 health survey (SF-36). Laboratory tests and clinical and demographic data were obtained. RESULTS: The patients were classified into CKD stages according to the CKD-EPI equation: 59,2% were in CKD Stage 1-3 and 40,8% were in Stage 4-5. The patients in Stage 4-5 had lower scores in physical aspects. Age influence QOL negatively. CKD patients with higher hemoglobin, albumin and 25 hydroxy vitamin D levels has better functional capacity and physical aspects. High HbA1c levels significantly associated with bad functional capacity. Education level and socioeconomic status is associated with QOL. CONCLUSIONS: Renal function, age, gender, education level and socioeconomic status influenced QOL. To imrove QOL in CKD patients we need to focus on factors that can be changed, such as improving the hemoglobin, albumin, HbA1c and 25 hydroxy vitamin D levels

Kaposi sarcoma development following microscopic polyangiitis treatment

Kaposi sarcoma (KS) is a rare condition mostly seen in immunosuppressed patients due to a syndrome or organ transplantation. However, few cases have been reported in patients with rheumatologic diseases treated with long-term corticosteroid and cyclophosphamide. We present a case in which the subject developed KS following a course of immunosuppressive therapy for their systemic vasculitides