288 research outputs found
Including Limited Partners in the Diversity Jurisdiction Analysis
This paper presents the results of the Dynamic Pricing Challenge, held on the occasion of the 17th INFORMS Revenue Management and Pricing Section Conference on June 29â30, 2017 in Amsterdam, The Netherlands. For this challenge, participants submitted algorithms for pricing and demand learning of which the numerical performance was analyzed in simulated market environments. This allows consideration of market dynamics that are not analytically tractable or can not be empirically analyzed due to practical complications. Our findings implicate that the relative performance of algorithms varies substantially across different market dynamics, which confirms the intrinsic complexity of pricing and learning in the presence of competition
Space Weather impact on the degradation of NOAA POES MEPED proton detectors
The Medium Energy Proton and Electron Detector (MEPED) on board the National
Oceanic and Atmospheric Administration Polar Orbiting Environmental Satellites
(NOAA POES) is known to degrade with time. In recent years a lot of effort has
been put into calibrating the degraded proton detectors. We make use of
previous work and show that the degradation of the detectors can be attributed
to the radiation dose of each individual instrument. However, the effectiveness
of the radiation in degrading the detector is modulated when it is weighted by
the mean index, increasing the degradation rate in periods with
high geomagnetic activity, and decreasing it through periods of low activity.
When taking and the radiation dose into account, we find that the
degradation rate is independent of spacecraft and detector pointing direction.
We have developed a model to estimate the correction factor for all the MEPED
detectors as a function of accumulated corrected flux and the
index. We apply the routine to NOAA POES spacecraft starting with NOAA-15,
including the European satellites MetOp-02 and MetOp-01, and estimate
correction factors
Implementation strategies to enhance the implementation of eHealth programs for patients with chronic illnesses: realist systematic review
Background: There is growing evidence of the positive effects of electronic health (eHealth) interventions for patients with chronic illness, but implementation of such interventions into practice is challenging. Implementation strategies that potentially impact implementation outcomes and implementation success have been identified. Which strategies are actually used in the implementation of eHealth interventions for patients with chronic illness and which ones are the most effective is unclear.
Objective: This systematic realist review aimed to summarize evidence from empirical studies regarding (1) which implementation strategies are used when implementing eHealth interventions for patients with chronic illnesses living at home, (2) implementation outcomes, and (3) the relationship between implementation strategies, implementation outcomes, and degree of implementation success.
Methods: A systematic literature search was performed in the electronic databases MEDLINE, Embase, PsycINFO, Scopus, Allied and Complementary Medicine Database, Cumulative Index to Nursing and Allied Health Literature, and Cochrane Library. Studies were included if they described implementation strategies used to support the integration of eHealth interventions into practice. Implementation strategies were categorized according to 9 categories defined by the Expert Recommendations for Implementing Change project: (1) engage consumers, (2) use evaluative and iterative strategies, (3) change infrastructure, (4) adapt and tailor to the context, (5) develop stakeholder interrelationships, (6) use financial strategies, (7) support clinicians, (8) provide interactive assistance, and (9) train and educate stakeholders. Implementation outcomes were extracted according to the implementation outcome framework by Proctor and colleagues: (1) acceptability, (2) adoption, (3) appropriateness, (4) cost, (5) feasibility, (6) fidelity, (7) penetration, and (8) sustainability. Implementation success was extracted according to the study authorsâ own evaluation of implementation success in relation to the used implementation strategies.
Results: The implementation strategies management support and engagement, internal and external facilitation, training, and audit and feedback were directly related to implementation success in several studies. No clear relationship was found between the number of implementation strategies used and implementation success.
Conclusions: This is the first review examining implementation strategies, implementation outcomes, and implementation success of studies reporting the implementation of eHealth programs for patients with chronic illnesses living at home. The review indicates that internal and external facilitation, audit and feedback, management support, and training of clinicians are of importance for eHealth implementation. The review also points to the lack of eHealth studies that report implementation strategies in a comprehensive way and highlights the need to design robust studies focusing on implementation strategies in the future.publishedVersio
the duality of uio 67 pt mofs connecting treatment conditions and encapsulated pt species by operando xas
XAS study of Pt-functionalized UiO-67 MOFs shows that 2 types of catalytically active sites can be formed in MOF cavities isolated Pt-complexes and Pt nanoparticles
Lifetime and point prevalence of psychotic symptoms in adults with bipolar disorders: a systematic review and meta-analysis
Psychotic symptoms, that we defined as delusions or hallucinations, are common in bipolar
disorders (BD). This systematic review and meta-analysis aims to synthesise the literature on
both lifetime and point prevalence rates of psychotic symptoms across different BD subtypes,
including both BD type I (BDI) and BD type II (BDII). We performed a systematic search of
Medline, PsycINFO, Embase and Cochrane Library until 5 August 2021. Fifty-four studies
(N = 23 461) of adults with BD met the predefined inclusion criteria for evaluating lifetime
prevalence, and 24 studies (N = 6480) for evaluating point prevalence. Quality assessment
and assessment of publication bias were performed. Prevalence rates were calculated using
random effects meta-analysis, here expressed as percentages with a 95% confidence interval
(CI). In studies of at least moderate quality, the pooled lifetime prevalence of psychotic
symptoms in BDI was 63% (95% CI 57.5â68) and 22% (95% CI 14â33) in BDII. For BDI
inpatients, the pooled lifetime prevalence was 71% (95% CI 61â79). There were no studies
of community samples or inpatient BDII. The pooled point prevalence of psychotic symptoms
in BDI was 54% (95 CI 41â67). The point prevalence was 57% (95% CI 47â66) in manic
episodes and 13% (95% CI 7â23.5) in depressive episodes. There were not enough studies
in BDII, BDI depression, mixed episodes and outpatient BDI. The pooled prevalence of
psychotic symptoms in BDI may be higher than previously reported. More studies are needed
for depressive and mixed episodes and community samples.
Prospero registration number: CRD 42017052706
tuning pt and cu sites population inside functionalized uio 67 mof by controlling activation conditions
The exceptional thermal and chemical stability of the UiO-66, -67 and -68 classes of isostructural MOFs [J. Am. Chem. Soc., 2008, 130, 13850] makes them ideal materials for functionalization purposes aimed at introducing active centres for potential application in heterogeneous catalysis. We previously demonstrated that a small fraction (up to 10%) of the linkers in the UiO-67 MOF can be replaced by bipyridine-dicarboxylate (bpydc) moieties exhibiting metal-chelating ability and enabling the grafting of Pt(ii) and Pt(iv) ions in the MOF framework [Chem. Mater., 2015, 27, 1042] upon interaction with PtCl2 or PtCl4 precursors. Herein we extend this functionalization approach in two directions. First, we show that by controlling the activation of the UiO-67-Pt we can move from a material hosting isolated Pt(ii) sites anchored to the MOF framework with Pt(ii) exhibiting two coordination vacancies (potentially interesting for CâH bond activation) to the formation of very small Pt nanoparticles hosted inside the MOF cavities (potentially interesting for hydrogenation reactions). The second direction consists of the extension of the approach to the insertion of Cu(ii), obtained via interaction with CuCl2, and exhibiting interesting redox properties. All materials have been characterized by in situ X-ray absorption spectroscopy at the Pt L3- and Cu K-edges
Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy
Objective
The anticonvulsant hypothesis posits that ECTâs mechanism of action is related to enhancement of endogenous anticonvulsant brain mechanisms. Results of prior studies investigating the role of the inhibitory neurotransmitter gammaâaminobutyric acid (âGABA+â, GABA and coedited macromolecules) in the pathophysiology and treatment of depression remain inconclusive. The aim of our study was to investigate treatmentâresponsive changes of GABA+ in subjects with a depressive episode receiving electroconvulsive therapy (ECT).
Methods
In total, 41 depressed subjects (DEP) and 35 healthy controls (HC) were recruited at two independent sites in Norway and the USA. MEGAâPRESS was used for investigation of GABA+ in the anterior cingulate cortex. We assessed longitudinal and crossâsectional differences between DEP and HC, as well as the relationship between GABA+ change and change in depression severity and number of ECTs. We also assessed longitudinal differences in cognitive performance and GABA+ levels.
Results
Depressive episode did not show a difference in GABA+ relative to HC (t71 = â0.36, p = .72) or in longitudinal analysis (t36 = 0.97, p = .34). Remitters and nonremitters did not show longitudinal (t36 = 1.12, p = .27) or crossâsectional differences in GABA+. GABA+ levels were not related to changes in antidepressant response (t35 = 1.12, p = .27) or treatment number (t36 = 0.05, p = .96). An association between cognitive performance and GABA+ levels was found in DEP that completed cognitive effortful testing (t18 = 2.4, p = .03).
Conclusion
Our results failed to support GABA as a marker for depression and abnormal mood state and provide no support for the anticonvulsant hypothesis of ECT. ECTâinduced change in GABA concentrations may be related to change in cognitive function.publishedVersio
Genes Suggest Ancestral Colour Polymorphisms Are Shared across Morphologically Cryptic Species in Arctic Bumblebees
email Suzanne orcd idCopyright: © 2015 Williams et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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