5 research outputs found
Families of Scroll Grid Attractors
In this paper a new family of scroll grid attractors is presented. These families are classied into three classes called 1D-, 2D- and 3D-grid scroll attractors depending on the location of the equilibrium points in state space. The scrolls generated from 1D-, 2D- and 3D-grid scroll attractors are located around the equilibrium points on a line, on a plane or in 3D, respectively. Due to the generalization of the nonlinear characteristics, it is possible to increase the number of scrolls in all state variable directions. A number of strange attractors from the scroll grid attractor families are presented. They have been experimentally veried using current feedback opamps
ATXN2 and its neighbouring gene SH2B3 are associated with increased ALS risk in the Turkish population
PubMedID: 22916186Expansions of the polyglutamine (polyQ) domain (?34) in Ataxin-2 (ATXN2) are the primary cause of spinocerebellar ataxia type 2 (SCA2). Recent studies reported that intermediate-length (27-33) expansions increase the risk of Amyotrophic Lateral Sclerosis (ALS) in 1-4% of cases in diverse populations. This study investigates the Turkish population with respect to ALS risk, genotyping 158 sporadic, 78 familial patients and 420 neurologically healthy controls. We re-assessed the effect of ATXN2 expansions and extended the analysis for the first time to cover the ATXN2 locus with 18 Single Nucleotide Polymorphisms (SNPs) and their haplotypes. In accordance with other studies, our results confirmed that 31-32 polyQ repeats in the ATXN2 gene are associated with risk of developing ALS in 1.7% of the Turkish ALS cohort (p = 0.0172). Additionally, a significant association of a 136 kb haplotype block across the ATXN2 and SH2B3 genes was found in 19.4% of a subset of our ALS cohort and in 10.1% of the controls (p = 0.0057, OR: 2.23). ATXN2 and SH2B3 encode proteins that both interact with growth receptor tyrosine kinases. Our novel observations suggest that genotyping of SNPs at this locus may be useful for the study of ALS risk in a high percentage of individuals and that ATXN2 and SH2B3 variants may interact in modulating the disease pathway. © 2012 Lahut et al