Review: Mycoendophytes in medicinal plants: Diversity and bioactivities

Rai M, Gade A, Rathod D, Dar M, Varma A. 2012. Review: Mycoendophytes in medicinal plants: Diversity and bioactivities. Nusantara Bioscience 4: 86-96. Endophytes are microorganisms that reside in internal tissues of living plants without causing any negative effect. These offer tremendous potential for the exploitation of novel and eco-friendly secondary metabolites used in medicine, the pharmaceutical industry and agriculture. The present review is focused on diversity of endophytes, current national and international bioactive secondary metabolite scenario and future prospects. Endophytic fungi as novel source of potentially useful medicinal compounds are discussed along with the need to search for new and more effective agents from endophytes to combat disease problems

Fractional flow reserve-guided management in stable coronary disease and acute myocardial infarction: recent developments

Coronary artery disease (CAD) is a leading global cause of morbidity and mortality, and improvements in the diagnosis and treatment of CAD can reduce the health and economic burden of this condition. Fractional flow reserve (FFR) is an evidence-based diagnostic test of the physiological significance of a coronary artery stenosis. Fractional flow reserve is a pressure-derived index of the maximal achievable myocardial blood flow in the presence of an epicardial coronary stenosis as a ratio to maximum achievable flow if that artery were normal. When compared with standard angiography-guided management, FFR disclosure is impactful on the decision for revascularization and clinical outcomes. In this article, we review recent developments with FFR in patients with stable CAD and recent myocardial infarction. Specifically, we review novel developments in our understanding of CAD pathophysiology, diagnostic applications, prognostic studies, clinical trials, and clinical guidelines

Guidance for assessment of the muscle mass phenotypic criterion for the Global Leadership Initiative on Malnutrition (GLIM) diagnosis of malnutrition

The Global Leadership Initiative on Malnutrition (GLIM) provides consensus criteria for the diagnosis of malnutrition that can be widely applied. The GLIM approach is based on the assessment of three phenotypic (weight loss, low body mass index, and low skeletal muscle mass) and two etiologic (low food intake and presence of disease with systemic inflammation) criteria, with diagnosis confirmed by any combination of one phenotypic and one etiologic criterion fulfilled. Assessment of muscle mass is less commonly performed than other phenotypic malnutrition criteria, and its interpretation may be less straightforward, particularly in settings that lack access to skilled clinical nutrition practitioners and/or to body composition methodologies. In order to promote the widespread assessment of skeletal muscle mass as an integral part of the GLIM diagnosis of malnutrition, the GLIM consortium appointed a working group to provide consensus-based guidance on assessment of skeletal muscle mass. When such methods and skills are available, quantitative assessment of muscle mass should be measured or estimated using dual-energy x-ray absorptiometry, computerized tomography, or bioelectrical impedance analysis. For settings where these resources are not available, then the use of anthropometric measures and physical examination are also endorsed. Validated ethnic- and sex-specific cutoff values for each measurement and tool are recommended when available. Measurement of skeletal muscle function is not advised as surrogate measurement of muscle mass. However, once malnutrition is diagnosed, skeletal muscle function should be investigated as a relevant component of sarcopenia and for complete nutrition assessment of persons with malnutrition

Intervención educativa en el nivel de conocimiento sobre anemia ferropénica en estudiantes de enfermería del Instituto Von Humboldt, Trujillo, 2021

El presente trabajo de investigación fue de nivel aplicativo, tipo cuantitativo, de diseño pre experimental, se realizó con el propósito de determinar la efectividad de una intervención educativa en el nivel de conocimiento sobre anemia ferropénica en los estudiantes de enfermería del Instituto Von Humboldt 2021. La muestra estuvo conformada por 90 estudiantes. Para la evaluación del nivel de conocimiento sobre anemia ferropénica se empleó como técnica la encuesta, como instrumento se utilizó el cuestionario para medir el nivel de conocimiento sobre anemia ferropénica, constituido por 20 ítems, correspondiendo a las dimensiones: Manifestaciones clínicas, diagnóstico, tratamiento y profilaxis. La intervención se desarrolló en 3 sesiones: La primera sesión abordó principalmente el desarrollo del pre test, la segunda sesión se aplicó la intervención educativa y la tercera sesión la evaluación post test. Se utilizó el Programa estadístico SPSS versión 26 y se aplicó la prueba estadística “t” Student para comparar el antes y después de la intervención. Al final se halló que, en el pre test, los estudiantes obtuvieron un promedio de 8.1 puntos y en el post test los estudiantes obtuvieron un promedio de 15.1 puntos siendo el aumento promedio de 7.0 puntos. Estableciéndose que existe diferencia significativa entre los puntajes obtenidos en pre test con los puntajes obtenidos en post test (p < 0,05). Se evidencia que la intervención educativa mejora el nivel de conocimiento sobre anemia ferropénica en los estudiantes de enfermería del Instituto Von Humboldt

Causas atribuibles a las agraviadas que influyen en el archivamiento de las investigaciones por violencia contra la mujer, fiscalía provincial penal corporativa de Leoncio Prado, 2019 – 2020

El objetivo general de la presente tesis es determinar las causas atribuibles a la agraviada que influyen en el archivamiento de las investigaciones por violencia contra la mujer, en la Fiscalía Provincial Penal Corporativa de Leoncio Prado, 2019 – 2020, para su desarrollo se ha empleado el tipo de investigación básico o teórico, con un enfoque cuantitativo y nivel descriptivo, el método con el cual se ha trabajado fue el deductivo; para su desarrollo se ha contado con una muestra de 121 casos archivados de investigaciones por violencia contra la mujer archivados en la indicada sede fiscal, obtenido mediante muestro probabilístico al azar, con un nivel de confianza del 95.0% y margen de error del 5.0%. De los resultados obtenidos se logró la comprobación de las hipótesis, confirmando que existen causas atribuibles a la agraviada que influyen significativamente en el archivamiento de las investigaciones por violencia contra la mujer ya que se observó una correlación positiva alta con un “r” = 0,931, aseverando que éstas corresponden a la dependencia económica de la mujer con el agresor, dependencia emocional y falta de soporte familiar, pues en mayoría de casos fueron archivados porque la agraviada no concurrió a las evaluaciones (50.42%), no se presentó a declarar (3.36%), de lo que se colige que la agraviada, luego de ser agredida y denunciar al agresor, ya no continúa con el proceso porque depende económica y emocionalmente de éste y además porque no tiene familia directa que la pueda apoyar, también se determinó que la mayoría de casos archivados corresponde a investigaciones por agresión psicológica

Financiamento à inovação e políticas públicas no Brasil : uma análise do período recente (2000-2010)

Orientador : Adriana Sbicca FernandesArtigo (especialização) - Universidade Federal do Paraná, Setor de Ciências Sociais Aplicadas. Curso de Especialização em Desenvolvimento Econômico.Inclui referênciasResumo: Os estudos de sistemas nacionais de inovação (SNI), introduzidos nas décadas de 1970 e 1980, ressaltaram a importância do aspecto sistêmico da inovação, relações entre empresas, setores, institutos e centros de pesquisa, instituições financeiras, bem como o papel central do conhecimento e sua difusão na economia e o apoio decisivo do Estado e suas instituições. Observou-se que nesses estudos o papel das instituições de financiamento não fazia parte da agenda principal de pesquisa, embora reconhecida sua importância. Buscando contribuir ao estudo de SNI, em especial aos investimentos em inovação, este trabalho apresentará o SNI do Brasil por meio de uma retomada da história das políticas de apoio implantadas no país e os atuais instrumentos de financiamento disponíveis a inovação, com o objetivo de evidenciar algumas deficiências que impedem o desenvolvimento do SNI brasileiro e explicam o baixo desempenho do país quanto a indicadores de inovação

Leishmaniasis: new approaches to disease control.

The leishmaniases afflict the world's poorest populations. Among the two million new cases each year in the 88 countries where the disease is endemic (fig 1), it is estimated that 80% earn less than $2 a day. Human infections with Leishmania protozoan parasites, transmitted via the bite of a sandfly, cause visceral, cutaneous, or mucocutaneous leishmaniasis. The global burden of leishmaniasis has remained stable for some years, causing 2.4 million disability adjusted life years (DALYs) lost and 59 000 deaths in 2001. Neglected by researchers and funding agencies, leishmaniasis control strategies have varied little for decades, but in recent years there have been exciting advances in diagnosis, treatment, and prevention. These include an immunochromatographic dipstick for diagnosing visceral leishmaniasis; the licensing of miltefosine, the first oral drug for visceral leishmaniasis; and evidence that the incidence of zoonotic visceral leishmaniasis in children can be reduced by providing dogs with deltamethrin collars. There is also hope that the first leishmaniasis vaccine will become available within a decade. Here we review these developments and identify priorities for research

The Independent, No. 21, March 9, 1978

The Independent was a student run newspaper created in 1960 at Newark State College, now Kean University. The proceeding title was The Reflector. The editor of this issue was Barbara Walcoff.https://digitalcommons.kean.edu/independent_1975-1979/1066/thumbnail.jp