Reconfiguration based built-in self-test for analogue front-end circuits

Previous work has shown that it is feasible to implement a fully digital test evaluation function to realise partial self-test on an automatic gain control circuit (AGC). This paper extends the technique to INL, DNL, offset & gain error testing of analogue to digital converters (ADC's). It also shows how the same function can be used to test an AGC / ADC pair. An extension to full self-test is also proposed by the on-chip generation of input stimuli through reconfiguration of existing functions

Design and debugging of multi-step analog to digital converters

With the fast advancement of CMOS fabrication technology, more and more signal-processing functions are implemented in the digital domain for a lower cost, lower power consumption, higher yield, and higher re-configurability. The trend of increasing integration level for integrated circuits has forced the A/D converter interface to reside on the same silicon in complex mixed-signal ICs containing mostly digital blocks for DSP and control. However, specifications of the converters in various applications emphasize high dynamic range and low spurious spectral performance. It is nontrivial to achieve this level of linearity in a monolithic environment where post-fabrication component trimming or calibration is cumbersome to implement for certain applications or/and for cost and manufacturability reasons. Additionally, as CMOS integrated circuits are accomplishing unprecedented integration levels, potential problems associated with device scaling – the short-channel effects – are also looming large as technology strides into the deep-submicron regime. The A/D conversion process involves sampling the applied analog input signal and quantizing it to its digital representation by comparing it to reference voltages before further signal processing in subsequent digital systems. Depending on how these functions are combined, different A/D converter architectures can be implemented with different requirements on each function. Practical realizations show the trend that to a first order, converter power is directly proportional to sampling rate. However, power dissipation required becomes nonlinear as the speed capabilities of a process technology are pushed to the limit. Pipeline and two-step/multi-step converters tend to be the most efficient at achieving a given resolution and sampling rate specification. This thesis is in a sense unique work as it covers the whole spectrum of design, test, debugging and calibration of multi-step A/D converters; it incorporates development of circuit techniques and algorithms to enhance the resolution and attainable sample rate of an A/D converter and to enhance testing and debugging potential to detect errors dynamically, to isolate and confine faults, and to recover and compensate for the errors continuously. The power proficiency for high resolution of multi-step converter by combining parallelism and calibration and exploiting low-voltage circuit techniques is demonstrated with a 1.8 V, 12-bit, 80 MS/s, 100 mW analog to-digital converter fabricated in five-metal layers 0.18-µm CMOS process. Lower power supply voltages significantly reduce noise margins and increase variations in process, device and design parameters. Consequently, it is steadily more difficult to control the fabrication process precisely enough to maintain uniformity. Microscopic particles present in the manufacturing environment and slight variations in the parameters of manufacturing steps can all lead to the geometrical and electrical properties of an IC to deviate from those generated at the end of the design process. Those defects can cause various types of malfunctioning, depending on the IC topology and the nature of the defect. To relive the burden placed on IC design and manufacturing originated with ever-increasing costs associated with testing and debugging of complex mixed-signal electronic systems, several circuit techniques and algorithms are developed and incorporated in proposed ATPG, DfT and BIST methodologies. Process variation cannot be solved by improving manufacturing tolerances; variability must be reduced by new device technology or managed by design in order for scaling to continue. Similarly, within-die performance variation also imposes new challenges for test methods. With the use of dedicated sensors, which exploit knowledge of the circuit structure and the specific defect mechanisms, the method described in this thesis facilitates early and fast identification of excessive process parameter variation effects. The expectation-maximization algorithm makes the estimation problem more tractable and also yields good estimates of the parameters for small sample sizes. To allow the test guidance with the information obtained through monitoring process variations implemented adjusted support vector machine classifier simultaneously minimize the empirical classification error and maximize the geometric margin. On a positive note, the use of digital enhancing calibration techniques reduces the need for expensive technologies with special fabrication steps. Indeed, the extra cost of digital processing is normally affordable as the use of submicron mixed signal technologies allows for efficient usage of silicon area even for relatively complex algorithms. Employed adaptive filtering algorithm for error estimation offers the small number of operations per iteration and does not require correlation function calculation nor matrix inversions. The presented foreground calibration algorithm does not need any dedicated test signal and does not require a part of the conversion time. It works continuously and with every signal applied to the A/D converter. The feasibility of the method for on-line and off-line debugging and calibration has been verified by experimental measurements from the silicon prototype fabricated in standard single poly, six metal 0.09-µm CMOS process

The Cleo Rich Detector

We describe the design, construction and performance of a Ring Imaging Cherenkov Detector (RICH) constructed to identify charged particles in the CLEO experiment. Cherenkov radiation occurs in LiF crystals, both planar and ones with a novel ``sawtooth''-shaped exit surface. Photons in the wavelength interval 135--165 nm are detected using multi-wire chambers filled with a mixture of methane gas and triethylamine vapor. Excellent pion/kaon separation is demonstrated.Comment: 75 pages, 57 figures, (updated July 26, 2005 to reflect reviewers comments), to be published in NIM

Pattern recognition in the detection of Tuberculous Meningitis

Includes bibliographical references (leaves 103-107)

Developing novel mucoadhesive chitosan based formulations for drug delivery to the urinary bladder

My PhD project aims to develop novel chitosan derivatives (with superior mucoadhesiveness) for transmucosal application. The intravesical route was chosen as the exemplar transmucosal mode of drug delivery due to the limited therapeutic efficiency of conventional bladder cancer formulations. Drug carriers with improved mucoadhesive properties may prolong drug residence in the bladder. First, three chitosan grades were used to prepare chitosan/β-glycerophosphate in situ gelling mixtures and from these grades, the high molecular weight graded chitosan (HCHI) was chosen for chemical derivatisation based on its superior gelation, mucoadhesive and drug release potential. HCHI was conjugated with varying amounts of methacrylate or phenylboronate groups in order to evaluate the influence of the type and amount of conjugated hydrophobic pendant group on their physicochemical and mucoadhesive properties. The boronated and methacrylated chitosans were characterised using 1H NMR and FT- IR. There was good correlation in the extent of hydrophobic modification for methacrylated and boronated chitosans using 1H NMR and ninhydrin test. Methacrylated and boronated chitosan exhibited comparable resistance to pH influence on their solubility. The degree of methacrylate or boronate conjugation had a significant influence on the mucoadhesiveness of the drug carriers studied using a urine flow-through technique/fluorescent microscopy as well as a texture analyser, on porcine bladder in vitro. Boronate groups conferred superior mucoadhesive behaviour on chitosan relative to methacrylate groups. Methacrylated chitosan displayed a similar safety profile to the parent chitosan based on MTT assay on UMUC3 bladder cancer cells. The biocompatibility studies of boronated chitosan will be carried out in future studies using bladder cell lines despite the fact that several in vitro and in vivo studies have established the safety of phenylboronic molecules. Methacrylation and boronation of chitosan has been identified as efficient strategies to generate more mucoadhesive drug carriers which could prolong drug residence time in the bladder thereby improving therapeutic outcomes of bladder cancer patients. These novel polymers were easily synthesised requiring minimal equipment suitable for industrial scale-up. These excipients could be used to formulate affordable transmucosal dosage forms with superior mucoadhesiveness for a variety of biomedical applications

Investigating graphene-based devices towards sensing applications.

Graphene is a novel material that has exceptional electrical properties. In this work the graphene-based devices were developed towards three applications. Graphene-glass electrodes were fabricated and characterised towards understanding the electrochemical nature of graphene. It was shown that graphene could serve as an electrochemical electrode towards use as a sensing platform due to its fast electron transfer characteristics and thus exhibited potential as a platform for electrochemical sensing of electroactive species. Further, the Graphene-on-Glass electrodes were shown to be used as a working electrode to create a reversible electrochromic device where the optical transparency of the Graphene was modulated, and the electrochemical characteristics of the Graphene device were examined. A proof-of-concept detection for the presence of a biomarker for Sepsis was developed. Large-area, functionalised graphene was shown to able to electronically sense the presence of the binding events of the Anti-PCT antibody, PCT molecule and differentiate from their bulk solution. The device was able to detect the presence of PCT over the medically relevant range.. This sensor combines the exceptional electrical properties of graphene leading to high sensitivity, which when functionalized also yields high specificity as a sensor platform and offers a new route for diagnosis of Sepsis electronically in real time measurements. Lastly, a hybrid graphene FET array that is embedded under microfluidic channels was developed. The effect of water on the device was measured and the utility of such devices towards sensing in aqueous media is discussed. Further, it is shown that the microfluidic channels of varying widths are able to transport water along the graphene FET array, such that individual graphene strips can sense them. This measurement scheme is extremely useful and can be adapted to a host of other sensing applications which would benefit from dynamic and precise control on the detection of the analyte

Onboard load sensor prototype for use in freight railcar service

Determining the exact load carried by an individual railcar is crucial in the railroad industry. With an accurate load measurement, the filling process can be optimized to provide maximum cargo load without exceeding the loading thresholds set by the Association of American Railroads (AAR). In addition to optimizing the cargo load, an accurate load measurement will make it possible to identify any load imbalance in the railcar which has detrimental effects on bearing. Previous work conducted with a strain-gauge-based load sensor suspended between a thermoplastic steering pad and a bearing adapter provided accurate load data in the laboratory setting. This thesis details the work performed to optimize the load sensor for use in freight railcars, which includes developing a calibration procedure suitable for field service. The thesis also summarizes the efforts undertaken to produce eight load sensor prototypes in preparation for field testing on a freight railcar

Optimized PET module for both pixelated and monolithic scintillator crystals

[eng] Time-of-Flight Positron Emission Tomography (TOF-PET) scanners demand fast and efficient photo-sensors and scintillators coupled to fast readout electronics. Nowadays, there are two main configurations regarding the scintillator crystal geometry: the segmented or pixelated and the monolithic approach. Depending on the cost, spatial resolution and time requirements of the PET module, one can choose between one or another. The pixelated crystal is the most extensive configuration on TOF-PET scanners as the coincidence time resolution is better compared to the monolithic. On the contrary, monolithic scintillator crystals for Time-of-Flight Positron Emission Tomography (ToF-PET) are increasing in popularity this last years due to their performance potential and price in front of the commonly used segmented crystals. On one hand, monolithic blocks allows to determine 3D information of the gamma-ray interaction inside the crystal, which enables the possibility to correct the parallax error (radial astigmatism) at off-center positions within a PET scanner, resulting in an improvement of the spatial resolution of the device. On the other hand, due to the simplicity during the crystal manufacturing process as well as for the detector design, the price is reduced compared to a regular pixelated detector. The thesis starts with the use of HRFlexToT, an ASIC developed in this group, as the readout electronics for measurements with single pixelated crystals coupled to different SiPMs. These measurements show an energy linearity error of 3% and an energy resolution below 10% of the 511 keV photopeak. Single Photon Time Resolution (SPTR) measurements performed using an FBK SiPM NUV-HD (4 mm x 4 mm pixel size) and a Hamamatsu SiPM S13360-3050CS gave a 141 ps and 167 ps FWHM respectively. Coincidence Time Resolution (CTR) measurements with small cross-section pixelated crystals (LFS crystal, 3 m x 3 mm x 20 mm ) coupled to a single Hamamatsu SiPM S13360-3050CS provides a CTR of 180 ps FWHM. Shorter crystals (LSO:Ce Ca 0.4%) coupled to a Hamamatsu S13360-3050CS SiPM or FBK-NUVHD yields a CTR of 117 ps and 119 ps respectively. Then, the results with different monolithic crystals and SiPM sensors using HRFlexToT ASIC will be presented. A Lutetium Fine Silicate (LFS) of 25 mm x 25 mm x 20 mm, a small LSO:Ce Ca 0.2% of 8 mm x 8 mm x 5 mm and a Lutetium-Yttrium Oxyorthosilicate (LYSO) of 25 mm x 25 mm x 10 mm has been experimentally tested. After subtracting the TDC contribution (82 ps FWHM), a coincidence time resolution of 244 ps FWHM for the small LFS crystal and 333 ps FWHM for the largest LFS one is reported. Additionally, a novel time calibration correction method for CTR improvement that involves a pico-second pulsed laser will be detailed. In the last part of the dissertation, a new developed simulation framework that will enable the cross-optimization of the whole PET system will be explained. It takes into consideration the photon physics interaction in the scintillator crystal, the sensor response (sensor size, pixel pitch, dead area, capacitance) and the readout electronics behavior (input impedance, noise, bandwidth, summation). This framework has allowed us to study a new promising approach that will help reducing the CTR parameter by segmenting a large area SiPM into "m" smaller SiPMs and then summing them to recover all the signal spread along these smaller sensors. A 15% improvement on time resolution is expected by segmenting a 4 mm x 4 mm single sensor into 9 sensors of 1.3 mm x 1.3 mm with respect to the case where no segmentation is applied.[cat] Aquesta tesi tenia com a objectiu la fabricació i avaluació d'un prototip per a detecció de fotons gamma en aplicació per imatge mèdica, més concretament en Tomografia per Emissió de Positrons amb mesura de temps de vol (TOF-PET). L'avaluació del mòdul va començar fent una caracterització completa del chip (ASIC) anomenat HRFlexToT, una versió nova i millorada de l'antic chip FlexToT, desenvolupat i fabricat pel grup de la Unitat Tecnològica del ICC de la Universitat de Barcelona. Aquesta avaluació inicial del chip compren des de la comprovació de les funcionalitats bàsiques fins a la generació d'un test automàtic per generar les gràfiques de linealitat corresponents durant el test elèctric. Un cop donat per bo, es va muntar en una placa demostrada, també ideada per l'equip d'enginyers del grup, i ja quedava llesta per realitzar les mesures pertinents. Tot seguit, es varen realitzar les mesures òptiques, que incloïa mesures de Singe Photon Time Resolution (SPTR) i de Coincidence Time Resolution (CTR). Aquest valors actuen com a figures de mèrit a l'hora de comparar les prestacions amb d'altres ASICs competidors del HRFlexToT. Es van obtenir valors de 60 ps de resposta pel que respecta al SPTR i de 115 ps de CTR en cristalls segmentats, una millora entorn del 20-30% respecte a la versió predecessora del chip. Aquests valors mostren ser el límit de l'estat de l'art actual i amb aquesta idea es van començar a fer altres mesures, en aquest cas amb cristall monolítics, blocs grans llegits per diversos fotosensors de les empreses Hamamatsu i FBK. Per altra banda, es va provar el funcionament del ASIC en configuració anomenada monolítica, on el cristall centellejador s'utilitza en blocs grans en coptes d’emprar cristalls segmentats, això abarateix el cost total del detector. Aquesta configuració degrada les propietats de CTR, un paràmetre crític a l'hora de tenir un producte bo i eficient. S’han obtingut mesures de 250 ps de CTR amb aquesta configuració, d’on es pot dir que l’HRFlexToT es trobar a l’estat de l’art de la tecnologia electrònica dedicada a TOF-PET amb cristalls segmentats i monolítics. Finalment, es va desenvolupar una nova eina simulació que consisteix en un sistema híbrid entre un simulador físic i un electrònic per tal de tenir una idea del comportament complet del mòdul detector. Una solució que ningú havia provat fins ara o que no es pot trobar en la literatura