A abordagem POESIA para a integração de dados e serviços na Web semantica

Orientador: Claudia Bauzer MedeirosTese (doutorado) - Universidade Estadual de Campinas, Instituto de ComputaçãoResumo: POESIA (Processes for Open-Ended Systems for lnformation Analysis), a abordagem proposta neste trabalho, visa a construção de processos complexos envolvendo integração e análise de dados de diversas fontes, particularmente em aplicações científicas. A abordagem é centrada em dois tipos de mecanismos da Web semântica: workflows científicos, para especificar e compor serviços Web; e ontologias de domínio, para viabilizar a interoperabilidade e o gerenciamento semânticos dos dados e processos. As principais contribuições desta tese são: (i) um arcabouço teórico para a descrição, localização e composição de dados e serviços na Web, com regras para verificar a consistência semântica de composições desses recursos; (ii) métodos baseados em ontologias de domínio para auxiliar a integração de dados e estimar a proveniência de dados em processos cooperativos na Web; (iii) implementação e validação parcial das propostas, em urna aplicação real no domínio de planejamento agrícola, analisando os benefícios e as limitações de eficiência e escalabilidade da tecnologia atual da Web semântica, face a grandes volumes de dadosAbstract: POESIA (Processes for Open-Ended Systems for Information Analysis), the approach proposed in this work, supports the construction of complex processes that involve the integration and analysis of data from several sources, particularly in scientific applications. This approach is centered in two types of semantic Web mechanisms: scientific workflows, to specify and compose Web services; and domain ontologies, to enable semantic interoperability and management of data and processes. The main contributions of this thesis are: (i) a theoretical framework to describe, discover and compose data and services on the Web, inc1uding mIes to check the semantic consistency of resource compositions; (ii) ontology-based methods to help data integration and estimate data provenance in cooperative processes on the Web; (iii) partial implementation and validation of the proposal, in a real application for the domain of agricultural planning, analyzing the benefits and scalability problems of the current semantic Web technology, when faced with large volumes of dataDoutoradoCiência da ComputaçãoDoutor em Ciência da Computaçã

A grid and cloud-based framework for high throughput bioinformatics

Recent advances in genome sequencing technologies have unleashed a flood of new data. As a result, the computational analysis of bioinformatics data sets has been rapidly moving from a labbased desktop computer environment to exhaustive analyses performed by large dedicated computing resources. Traditionally, large computational problems have been performed on dedicated clusters of high performance machines that are typically local to, and owned by, a particular institution. The current trend in Grid computing has seen institutions pooling their computational resources in order to offload excess computational work to remote locations during busy periods. In the last year or so, commercial Cloud computing initiatives have matured enough to offer a viable remote source of reliable computational power. Collections of idle desktop computers have also been used as a source of computational power in the form of ‘volunteer Grids’. The field of bioinformatics is highly dynamic, with new or updated versions of software tools and databases continually being developed. Several different tools and datasets must often be combined into a coherent, automated workflow or pipeline. While existing solutions are available for constructing workflows, there is a clear need for long-lived analyses consisting of many interconnected steps to be able to migrate among Grid and cloud computational resources dynamically. This project involved research into the principles underlying the design and architecture of flexible, high-throughput bioinformatics processes. Following extensive research into requirements gathering, a novel Grid-based platform, Microbase, has been implemented that is based on service-oriented architectures and peer-to-peer data transfer technology. This platform has been shown to be amenable to utilising a wide range of hardware from commodity desktop computers, to high-performance cloud infrastructure. The system has been shown to drastically reduce the bandwidth requirements of bioinformatics data distribution, and therefore reduces both the financial and computational costs associated with cloud computing. The system is inherently modular in nature, comprising a service based notification system, a data storage system scheduler and a job manager. In keeping with e-Science principles, each module can operate in physical isolation from each other, distributed within an intranet or Internet. Moreover, since each module is loosely coupled via Web services, modules have the potential to be used in combination with external service oriented components or in isolation as part of another system. In order to demonstrate the utility of such an open source system to the bioinformatics community, a pipeline of inter-connected bioinformatics applications was developed using the Microbase system to form a high throughput application for the comparative and visual analysis of microbial genomes. This application, Automated Genome Analyser (AGA) has been developed to operate without user interaction. AGA exposes its results via Web-services which can be used by further analytical stages within Microbase, by external computational resources via a Web service interface or which can be queried by users via an interactive genome browser. In addition to providing the necessary infrastructure for scalable Grid applications, a modular development framework has been provided, which simplifies the process of writing Grid applications. Microbase has been adopted by a number of projects ranging from comparative genomics to synthetic biology simulations.EThOS - Electronic Theses Online ServiceGBUnited Kingdo