387,660 research outputs found

    Bridging the gap between methods research and the needs of policy makers: A review of the research priorities of the National Institute for Health and Clinical Excellence

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    Objectives: The aim of this study was to establish a list of priority topics for methods research to support decision making at the National Institute for Health and Clinical Excellence (NICE). Methods: Potential priorities for methods research topics were identified through a focused literature review, interviews, an email survey, a workshop and a Web-based feedback exercise. Participants were members of the NICE secretariat and its advisory bodies, representatives from academia, industry, and other organizations working closely with NICE. The Web exercise was open to anyone to complete but publicized among the above groups. Results: A list of potential topics was collated. Priorities for further research differed according to the type of respondent and the extent to which they work directly with NICE. Priorities emerging from the group closest to NICE included: methodology for indirect and mixed treatment comparisons; synthesis of qualitative evidence; research relating to the use of quality-adjusted life-years (QALYs) in decision making; methods and empirical research for establishing the cost-effectiveness threshold; and determining how data on the uncertainty of effectiveness and cost-effectiveness data should be taken into account in the decision-making process. Priorities emerging from the broadest group of respondents (through the Web exercise) included: methods for extrapolating beyond evidence observed in trials, methods for capturing benefits not included in the QALY and methods to assess when technologies should be recommended in the context of further evidence gathering. Conclusions: Consideration needs to be given to the needs of those who use the outputs of research for decision making when determining priorities for future methods research.NIHR Medical Research Council

    Integrated Design Tools for Embedded Control Systems

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    Currently, computer-based control systems are still being implemented using the same techniques as 10 years ago. The purpose of this project is the development of a design framework, consisting of tools and libraries, which allows the designer to build high reliable heterogeneous real-time embedded systems in a very short time at a fraction of the present day costs. The ultimate focus of current research is on transformation control laws to efficient concurrent algorithms, with concerns about important non-functional real-time control systems demands, such as fault-tolerance, safety,\ud reliability, etc.\ud The approach is based on software implementation of CSP process algebra, in a modern way (pure objectoriented design in Java). Furthermore, it is intended that the tool will support the desirable system-engineering stepwise refinement design approach, relying on past research achievements ¿ the mechatronics design trajectory based on the building-blocks approach, covering all complex (mechatronics) engineering phases: physical system modeling, control law design, embedded control system implementation and real-life realization. Therefore, we expect that this project will result in an\ud adequate tool, with results applicable in a wide range of target hardware platforms, based on common (off-theshelf) distributed heterogeneous (cheap) processing units

    Water Rights and Water Allocation: Issues and Challenges for Asia

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    The primary audience for this report is management and staff working in water resources agencies in Asia, particularly those in river basin organizations (RBOs) in their various forms. The roles and responsibilities of RBOs vary considerably and are evolving as pressureson water resources are becoming more severe. Although this report seeks to share knowledge about the fundamentals and application of waterrights and allocation, it attempts to do so with a practical focus

    The Scalability-Efficiency/Maintainability-Portability Trade-off in Simulation Software Engineering: Examples and a Preliminary Systematic Literature Review

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    Large-scale simulations play a central role in science and the industry. Several challenges occur when building simulation software, because simulations require complex software developed in a dynamic construction process. That is why simulation software engineering (SSE) is emerging lately as a research focus. The dichotomous trade-off between scalability and efficiency (SE) on the one hand and maintainability and portability (MP) on the other hand is one of the core challenges. We report on the SE/MP trade-off in the context of an ongoing systematic literature review (SLR). After characterizing the issue of the SE/MP trade-off using two examples from our own research, we (1) review the 33 identified articles that assess the trade-off, (2) summarize the proposed solutions for the trade-off, and (3) discuss the findings for SSE and future work. Overall, we see evidence for the SE/MP trade-off and first solution approaches. However, a strong empirical foundation has yet to be established; general quantitative metrics and methods supporting software developers in addressing the trade-off have to be developed. We foresee considerable future work in SSE across scientific communities.Comment: 9 pages, 2 figures. Accepted for presentation at the Fourth International Workshop on Software Engineering for High Performance Computing in Computational Science and Engineering (SEHPCCSE 2016

    On the Potential of Generic Modeling for VANET Data Aggregation Protocols

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    In-network data aggregation is a promising communication mechanism to reduce bandwidth requirements of applications in vehicular ad-hoc networks (VANETs). Many aggregation schemes have been proposed, often with varying features. Most aggregation schemes are tailored to specific application scenarios and for specific aggregation operations. Comparative evaluation of different aggregation schemes is therefore difficult. An application centric view of aggregation does also not tap into the potential of cross application aggregation. Generic modeling may help to unlock this potential. We outline a generic modeling approach to enable improved comparability of aggregation schemes and facilitate joint optimization for different applications of aggregation schemes for VANETs. This work outlines the requirements and general concept of a generic modeling approach and identifies open challenges
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